Cell therapy for renal regeneration - Time for some joined-up thinking?

Nephrology Dialysis Transplantation

Volumn 21, Issue 12, 2006, Pages 3349-3353

  Poulsom, Richard ^a   Prodromidi, Evangelia I ^b   Pusey, Charles D ^b   Cook, H Terence ^b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Alport syndrome; Fusion; Renal regeneration; Stem cells; Stem therapy

Indexed keywords

CELL FUSION; CELL REGENERATION; CELL TYPE; HEMATOPOIETIC STEM CELL; HUMAN; KIDNEY CELL; KIDNEY INJURY; KIDNEY PARENCHYMA; MESENCHYMAL STEM CELL; NONHUMAN; NOTE; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; TISSUE REGENERATION;

ANIMALS; HUMANS; KIDNEY; REGENERATION; STEM CELL TRANSPLANTATION;

EID: 33751400880     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfl490     Document Type: Note

References (49)

1. Held PK, Al-Dhalimy M, Willenbring H et al. In vivo genetic selection of renal proximal tubules. Mol Ther 2006; 13: 49-58
2. Sugimoto H, Mundel TM, Sund M, Xie L, Cosgrove D, Kalluri R. Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease. Proc Natl Acad Sci USA 2006; 103: 7321-7326
3. Prodromidi EI, Poulsom R, Jeffery R et al. Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome. Stem Cells 2006 July 27; [Epub ahead of print].
4. Rama P, Bonini S, Lambiase A et al. Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency. Transplantation 2001; 72: 1478-1485
5. Ferrari S, Pellegrini G, Matsui T, Mavilio F, De Luca M. Gene therapy in combination with tissue engineering to treat epidermolysis bullosa. Expert Opinion on Biological Therapy 2006; 6: 367-378
6. Al-Awqati Q, Oliver JA. Stem cells in the kidney. Kidney Int 2002; 61: 387-395
7. Elger M, Hentschel H, Litteral J et al. Nephrogenesis is induced by partial nephrectomy in the elasmobranch Leucoraja erinacea. J Am Soc Nephrol 2003; 14: 1506-1518
8. Salice CJ, Rokous JS, Kane AS, Reimschuessel R. New nephron development in goldfish (Carassius auratus) kidneys following repeated gentamicin-induced nephrotoxicosis. Comp Med 2001; 51: 56-59
9. Oliver JA, Maarouf O, Cheema FH, Martens TP, Al-Awqati Q. The renal papilla is a niche for adult kidney stem cells. J Clin Invest 2004; 114: 795-804
10. Humes HD, Krauss JC, Cieslinski DA, Funke AJ. Tubulogenesis from isolated single cells of adult mammalian kidney: Clonal analysis with a recombinant retrovirus. Am J Physiol 1996; 271: F42-F49
11. Kitamura S, Yamasaki Y, Kinomura M et al. Establishment and characterization of renal progenitor like cells from S3 segment of nephron in rat adult kidney. FASEB J 2005; 19: 1789-1797
12. Humes HD, Weitzel WF, Bartlett RH et al. Initial results of the bioartificial kidney containing human cells in ICU patients with acute renal failure. Kidney Int 2004; 66: 1578-1588
13. Bussolati B, Bruno S, Grange C et al. Isolation of renal progenitor cells from adult human kidney. Am J Pathol 2005; 166: 545-555
14. da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 2006; 119: 2204-2213
15. Traver D, Paw BH, Poss KD, Penberthy WT, Lin S, Zon LI. Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol 2003; 4: 1238-1246
16. Poulsom R, Forbes SJ, Hodivala-Dilke K et al. Bone marrow contributes to renal parenchymal turnover and regeneration. J Pathol 2001; 195: 229-235
17. Mengel M, Jonigk D, Marwedel M et al. Tubular chimerism occurs regularly in renal allografts and is not correlated to outcome. J Am Soc Nephrol 2004; 15: 978-986
18. Krause D, Cantley LG. Bone marrow plasticity revisited: Protection or differentiation in the kidney tubule? J Clin Invest 2005; 115: 1705-1708
19. Reinders ME, Rabelink TJ, Briscoe DM. Angiogenesis and endothelial cell repair in renal disease and allograft rejection. J Am Soc Nephrol 2006; 17: 932-942
20. Lagaaij E, Cramer-Knijnenburg G, van Kemenade F, van Es L, Bruijn J, van Krieken J. Endothelial cell chimerism after renal transplantation and vascular rejection. Lancet 2001; 357: 33-37
21. Poulsom R, Alison MR, Forbes SJ, Wright NA. Adult stem cell plasticity. J Pathol 2002; 197: 441-456
22. Cornacchia F, Fornoni A, Plati AR et al. Glomerulosclerosis is transmitted by bone marrow-derived mesangial cell progenitors. J Clin Invest 2001; 108: 1649-1656
23. Li B, Morioka T, Uchiyama M, Oite T. Bone marrow cell infusion ameliorates progressive glomerulosclerosis in an experimental rat model. Kidney Int 2006; 69: 323-330
24. Grimm PC, Nickerson P, Jeffery J et al. Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection. N Engl J Med 2001; 345: 93-97
25. Roufosse C, Bou-Gharios G, Prodromidi E et al. Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis. J Am Soc Nephrol 2006; 17: 775-782
26. Poulsom R, Alison MR, Cook T et al. Bone marrow stem cells contribute to healing of the kidney. J Am Soc Nephrol 2003; 14: S48-S54
27. Stokman G, Leemans JC, Claessen N, Weening JJ, Florquin S. Hematopoietic stem cell mobilization therapy accelerates recovery of renal function independent of stem cell contribution. J Am Soc Nephrol 2005; 16: 1684-1692
28. Lin F, Cordes K, Li L et al. Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice. J Am Soc Nephrol 2003; 14: 1188-1199
29. Kale S, Karihaloo A, Clark PR, Kashgarian M, Krause DS, Cantley LG. Bone marrow stem cells contribute to repair of the ischemically injured renal tubule. J Clin Invest 2003; 112: 42-49
30. Morigi M, Imberti B, Zoja C et al. Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 2004; 15: 1794-1804
31. Krause D, Theise N, Collector M et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105: 369-377
32. Fang TC, Alison MR, Cook HT, Jeffery R, Wright NA, Poulsom R. Proliferation of bone marrow-derived cells contributes to regeneration after folic acid-induced acute tubular injury. J Am Soc Nephrol 2005; 16: 1723-1732
33. Iwasaki M, Adachi Y, Minamino K et al. Mobilization of bone marrow cells by G-CSF rescues mice from cisplatin-induced renal failure, and M-CSF enhances the effects of G-CSF. J Am Soc Nephrol 2005; 16: 658-666
34. Togel F, Isaac J, Westenfelder C. Hematopoietic stem cell mobilization-associated granulocytosis severely worsens acute renal failure. J Am Soc Nephrol 2004; 15: 1261-1267
35. Fang TC, Poulsom R. Cell-based therapies for birth defects: A role for adult stem cell plasticity? Birth Defects Res Part C Embryo Today 2003; 69: 238-249
36. Ogle BM, Cascalho M, Platt JL. Biologocal implications of cell fusion. Nat Rev Mol Cell Biol 2005; 6: 567-575
37. Lagasse E, Connors H, Al-Dhalimy M et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000; 6: 1229-1234
38. Daley GQ. Alchemy in the liver: Fact or fusion? Nat Med 2004; 10: 671-672
39. Togel F, Hu Z, Weiss K, Isaac J, Lange C, Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 2005; 289: F31-F42
40. Anjos-Afonso F, Siapati EK, Bonnet D. In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions. J Cell Sci 2004; 117: 5655-5664
41. Fang TC, Alison MR, Wright NA, Poulsom R. Adult stem cell plasticity: will engineered tissues be rejected? Int J Exp Pathol 2004; 85: 115-124
42. Shemer G, Podbilewicz B. Fusomorphogenesis: Cell fusion in organ formation. Dev Dyn 2000; 218: 30-51
43. Kollet O, Dar A, Shivtiel S et al. Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells dicine. Nat Med 2006; 12: 657-664
44. Ash P, Loutit JF, Townsend KM. Osteoclasts derive from hematopoietic stem cells according to marker, giant lysosomes of beige mice. Clin Orthop Relat Res 1981; 249-258
45. Blau HM. A twist of fate. Nature 2002; 419: 437
46. Weimann JM, Charlton CA, Brazelton TR, Hackman RC, Blau HM. Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains. Proc Natl Acad Sci USA 2003; 100: 2088-2093
47. Kashofer K, Siapati EK, Bonnet D. In vivo formation of unstable heterokaryons following damage and HSC/Progenitor transplantation. Stem Cells 2006; 24: 1104-1112
48. Katayama K, Nomura S, Kawano M et al. Simple bone marrow transplantation of wild-type mouse prolongs the survival of COL4A3 knockout mouse; a mouse model of Alport syndrome. J Am Soc Nephrol 2005; 16: 227A
49. Ninichuk V, Gross O, Segerer S et al. Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice. Kidney Int 2006; 70: 121-129