DHPS-mutated isolates of Pneumocystis jirovecii from HIV-infected individuals: Analysis of related ITS genotypes

Journal of Eukaryotic Microbiology

Volumn 53, Issue SUPPL. 1, 2006, Pages

  Valerio, Antonella ^a   Tronconi, Elisa ^a   Mazza, Francesca ^a   Cargnel, Antonietta ^a   Fantoni, Giovanna ^a   Atzori, Chiara ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPTEROATE SYNTHASE; FUNGAL DNA; FUNGAL PROTEIN; RIBOSOMAL SPACER DNA;

FUNGUS; GENOTYPE; HUMAN IMMUNODEFICIENCY VIRUS;

ADULT; AGED; AIDS RELATED COMPLEX; CHEMISTRY; CLASSIFICATION; CONFERENCE PAPER; DNA SEQUENCE; EPIDEMIOLOGY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HOSPITAL; HUMAN; ISOLATION AND PURIFICATION; ITALY; LUNG LAVAGE; MICROBIOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; PNEUMOCYSTIS JIROVECI; PNEUMOCYSTIS PNEUMONIA; POINT MUTATION; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; AGED; AIDS-RELATED OPPORTUNISTIC INFECTIONS; BRONCHOALVEOLAR LAVAGE FLUID; DIHYDROPTEROATE SYNTHASE; DNA, FUNGAL; DNA, RIBOSOMAL SPACER; EPIDEMIOLOGY, MOLECULAR; FUNGAL PROTEINS; GENOTYPE; HOSPITALS; HUMANS; ITALY; MIDDLE AGED; PNEUMOCYSTIS JIROVECI; PNEUMONIA, PNEUMOCYSTIS; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SEQUENCE ANALYSIS, DNA;

HUMAN IMMUNODEFICIENCY VIRUS; PNEUMOCYSTIS JIROVECII;

EID: 33751384647     PISSN: 10665234     EISSN: 15507408     Source Type: Journal    
DOI: 10.1111/j.1550-7408.2006.00192.x     Document Type: Conference Paper

References (10)

1. Crothers, K., Beard, C. B., Turner, J., Groner, G., Fox, M., Morris, A., Eiser, S. & Huang, L. 2005. Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations. AIDS, 19:801-805.
2. Helweg-Larsen, J., Eugen-Olsen, J. & Lundgren, B. 2000. Rapid detection of dihydropteroate polymorphism in AIDS-related Pneumocystis carinii pneumonia by restriction fragment length polymorphism. Scand. J. Infect. Dis., 32:481-483.
3. Huang, L., Crothers, K., Atzori, C., Benfield, T., Miller, R., Rabodonirina, M. & Helweg-Larsen, J. 2004. Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance. Emerg. Infect. Dis., 10:1721-1728.
4. Kazanjian, P., Armstrong, W., Hossler, P. A., Burman, W., Richardson, J., Lee, C. H., Crane, L., Katz, J. & Meshnick, S. R. 2000. Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patients. J. Infect. Dis., 182:551-557.
5. Kazanjian, P. H., Fisk, D., Armstrong, W., Shulin, Q., Liwei, H., Ke, Z. & Meshnick, S. R. 2004. Increase in prevalence of Pneumocystis carinii mutations in patients with AIDS and P. carinii pneumonia, in the United States and China. J. Infect. Dis., 189:1684-1687.
6. Lane, B. R., Ast, J. C., Hossler, P.A, Mindell, D. P., Bartlett, M. S., Smith, J. W. & Meshnick, S. R. 1997. Dihydropteroate synthase polymorphisms in Pneumocystis carinii. J. Infect. Dis., 175:482-485.
7. Lee, C. H., Helweg-Larsen, J., Tang, X., Jin, S., Li, B., Bartlett, M. S., Lu, J., Lundgren, B., Lundgren, J. D., Olsson, M., Lucas, S. B., Roux, P., Cargnel, A., Atzori, C., Matos, O. & Smith, J. W. 1998. Update on Pneumocystis carinii f. sp. hominis typing based on nucleotide sequence variations in internal transcribed spacer regions of rRNA genes. J. Clin. Microbiol., 36:734-741.
8. Ma, L., Borio, L., Masur, H. & Kovacs, J. A. 1999. Pneumocystis carinii dihydropteroate synhthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use. J. Infect. Dis., 180:1969-1978.
9. Ma, L., Kovacs, J. A., Cargnel, A., Valerio, A., Fantoni, G. & Attori, C. 2002. Mutations in dihydropteroate synthase gene of human-derived Pneumocystis carinii isolates from Italy are infrequent but correlate with prior sulfa prophylaxis. J. Infect. Dis., 185:1530-1532.
10. Morris, A., Lundgren, J. D., Masur, H., Walzer, P. D., Hanson, D. L., Frederick, T., Huang, L., Beard, C. B. & Kaplan, J. E. 2004. Current epidemiology of Pneumocystis pneumonia. Emerg. Infect. Dis., 10:1713-1720.