The effect of blood glucose levels on hemorheological parameters, platelet activation and aggregation in oral glucose tolerance tests

Clinical Hemorheology and Microcirculation

Volumn 35, Issue 4, 2006, Pages 517-525

  Koltai, Katalin ^a   Feher, Gergely ^a   Kesmarky, Gabor ^a   Keszthelyi, Zsuzsa ^a   Czopf, Laszlo ^a   Toth, Kalman ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Blood viscosity; BMI; Erythrocyte aggregation; Erythrocyte deformability; OGTT; Platelet aggregation; sP selectin

Indexed keywords

GLUCOSE; PADGEM PROTEIN;

ADULT; AGED; ARTICLE; BLOOD RHEOLOGY; BLOOD VISCOSITY; BODY MASS; CLINICAL ARTICLE; DIABETES MELLITUS; ERYTHROCYTE AGGREGATION; FEMALE; GLUCOSE BLOOD LEVEL; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HUMAN; IMPAIRED GLUCOSE TOLERANCE; MALE; ORAL GLUCOSE TOLERANCE TEST; THROMBOCYTE ACTIVATION;

AGED; BLOOD GLUCOSE; BLOOD VISCOSITY; DIABETES COMPLICATIONS; DIABETES MELLITUS; ERYTHROCYTE AGGREGATION; ERYTHROCYTE DEFORMABILITY; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HEMORHEOLOGY; HUMANS; HYPERINSULINISM; MALE; MIDDLE AGED; PLATELET ACTIVATION; PLATELET AGGREGATION;

EID: 33751375954     PISSN: 13860291     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. P. André, D. Hartwell, I. Hrachovinová, S. Saffaripour and D. Wagner, Pro-coagulant state resulting from high levels of soluble P-selectin in blood, Proc. Natl. Acad. Sci. USA 25 (2000), 13835-13840.
2. N. Babu and M. Singh, Influence of hyperglycemia on aggregation, deformability and shape parameters of erythrocytes, Clin. Hemorheol. Microcirc. 31 (2004), 273-280.
3. O.K. Baskurt, R. Levi, S. Caglayan, N. Dikmenoglu, O. Ucer, R. Guner and S. Yorukan, The role of hemorheologic factors in the coronary circulation, Clin. Hemorheol. 11 (1991), 121-127.
4. D. Blann, S.K. Nadar and G.Y.H. Lip, The adhesion molecule P-selectin and cardiovascular disease, Eur. Heart J. 24 (2003), 2166-2179.
5. M. Bo, S. Raspo, F. Morra, M. Cassader, G. Isaia and L. Poli, Body fat is the main predictor of fibrinogen levels in healthy non-obese men, Metabolism 53 (2004), 984-988.
6. J.F. Brun, I. Aloulou and E. Varlet-Marie, Hemorheological aspects of the metabolic syndrome: markers of insulin resistance, obesity or hyperinsulinaemia?, Clin. Hemorheol. Microcirc. 30 (2004), 203-209.
7. C. Carter, D. McGee, D. Reed, K. Yano and G. Stemmermann, Hematocrit and the risk of coronary heart disease: The Honolulu Heart Program, Am. Heart J. 105 (1983), 674-679.
8. S.G.D. Conway, L.A. Pearce, B.S.P. Chin, R.G. Hart and G.Y.H. Lip, Plasma von Willebrand factor and soluble P-selectin as indices of endothelial damage and platelet activation in 1321 patients with nonvalvular atrial fibrillation, Circulation 106 (2002), 1962-1967.
9. J.P. De La Cruz, M.M. Arrebola, M.A. Villalobos, A. Pinacho, A. Guerrero, J.A. González-Correa and F.S. de la Cuesta, Influence of glucose concentration on the effects of aspirin, ticlopidine and clopidogrel on platelet function and platelet-subendothelium interaction, Eur. J. Pharmacol. 484 (2004), 19-27.
10. C. Le Devehat, T. Khodabandehlou, M. Vimeux and F. Aouane, Diabetes mellitus: its effects on blood rheological properties and microcirculatory consequences, Clin. Hemorheol. 16 (1996), 677-683.
11. C. Le Devehat, M. Vimeux and T. Khodabandehlou, Blood rheology in patients with diabetes mellitus, Clin. Hemorheol. Microcirc. 56 (2004), 297-230.
12. J. Dormandy, Cardiovascular diseases, in: Clinical Hemorheology, S. Chien, J. Dormandy, E. Ernst and A. Matrai, eds, Martinus Nijhoff Publishers, Dordrecht, 1987, pp. 165-194.
13. R. Junker, J. Heinrich, H. Ulbrich, H. Schulte, R. Schönfeld, E. Köhler and G. Assmann, Relationship between plasma viscosity and the severity of coronary heart disease, Arterioscler. Thromb. Vasc. Biol. 18 (1998), 870-875.
14. W.B. Kannel, R.B. D'Agostino and A.J. Belanger, Fibrinogen, cigarette smoking, and risk of cardiovascular disease: Insights from the Framingham Study, Am. Heart J. 113 (1987), 1006-1010.
15. F.K. Keating, B.E. Sobel and D.J. Schneider, Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus, Am. J. Cardiol. 92 (2003), 1362-1365.
16. G. Kesmarky, K. Toth, L. Habon, G. Vajda and I. Juricskay, Hemorheological parameters in coronary artery disease, Clin. Hemorheol. Microcirc. 18 (1998), 245-251.
17. T. Khodabandehlou, H. Zhao, M. Vimeux, F. Aouane and C. Le Devehat, Hemorheological consequences of hyperglycaemic spike in healthy volunteers and insulin-dependent diabetics, Clin. Hemorheol. Microcirc. 19 (1998), 105-114.
18. H.J. Klose, E. Volger, H. Brechtelsbauer, L. Heinrich and H. Schmied-Schonbein, Microrheology and light transmission in blood, Pflugers Arch. 333 (1972), 126-139.
19. H. Knobler, N. Savion, B. Shenkman, S. Kotev-Emeth and D. Varon, Shear-induced platelet adhesion and aggregation on subendothelium are increased in diabetic patients, Thromb. Res. 90 (1998), 181-190.
20. R. Lo Presti, D. Sinagra, M. Montana, A.M. Scarpitta, A. Catania and G. Caimi, Haemorheological profile in metabolic syndrome, Clin. Hemorheol. Microcirc. 26 (2002), 241-247.
21. Zs. Marton, G. Kesmarky, J. Vekasi, A. Cser, R. Russai, B. Horvath and K. Toth, Red blood cell aggregation measurements in whole blood and in fibrinogen solutions by different methods, Clin. Hemorheol. Microcirc. 24 (2001), 75-83.
22. F.J. Neumann, H.A. Katus, E. Hoberg, P. Roebruck, M. Braun, H.M. Haupt, H. Tillmanns and W. Kubler, Increased plasma viscosity and erythrocyte aggregation-indicators of an unfavourable clinical outcome in patients with unstable angina pectoris, Br. Heart J. 66 (1991), 425-430.
23. F.J. Neumann, H. Tillmanns, P. Roebruck, R. Zimmermann, H.M. Haupt and W. Kubler, Haemorrheological abnormalities in unstable angina pectoris: a relation independent of risk factor profile and angiographic severity, Br. Heart J. 62 (1989), 421-428.
24. C. Opper, N. Weiner, F. Xu, W. Adam, H. Fruhstorfer and W. Wesemann, Daily variations of functional parameters and density distribution in human blood platelets, Chronobiol. Int. 11 (1994), 309-319.
25. A. Pérez-Martin, M. Dumortier, E. Pierrisnard, E. Raynaud, J. Mercier and J.F. Brun, Multivariate analysis of relationships between insulin sensitivity and blood rheology: Is plasma viscosity a marker of insulin resistance?, Clin. Hemorheol. Microcirc. 25 (2001), 91-103.
26. D. Samocha-Bonet, D. Lichtenberg, A. Tomer, V. Deutsch, T. Mardi, Y. Goldin, S. Abu-Abeid, G. Shenkerman, H. Pat shornik, I. Shapira and S. Berliner, Enhanced erythrocyte adhesiveness/aggregation in obesity corresponds to low-grade inflammation, Obes. Res. 11 (2003), 403-407.
27. J.A. Tooke and A.C. Shore, The regulation of microvascular function in diabetes mellitus, in: Chronic Complications of Diabetes, J.C. Pickup and G. Williams, eds, Blackwell, Boston, 1994, pp. 34-41.
28. J. Vekasi, Zs. Marton, G. Kesmarky, A. Cser, R. Russai and B. Horvath, Hemorheological alterations in patients with diabetic retinopathy. Clin. Hemorheol. Microcirc. 24 (2001), 59-64.
29. E. Véricel, C. Januel, M. Carreras, P. Moulin and M. Lagarde, Diabetic patients without vascular complications display enhanced basal platelet activation and decreased antioxidant status, Diabetes 53 (2004), 1046-1051.
30. C. Watala, J. Golanski, J. Pluta, M. Boncler, M. Rozalski, B. Luzak and A. Kropiwnicka, Reduced sensitivity of platelets from type 2 diabetic patients to acetylsalicylic acid (aspirin)-its relation to metabolic control, Thromb. Res. 113 (2004), 101-113.
31. O. Ziegler, B. Guerci, H. Candiloros, L. Méjean, M. Donner, J. F. Stoltz and P. Drouin, Increased erythrocyte aggregation in insulin-dependent diabetes mellitus and its relationship to plasma factors: A multivariate analysis, Metabolism 43 (1994), 1182-1186.