Delta-9-tetrahydrocannabinol, the major psychoactive component in marijuana, inhibits macrophage chemotaxis to Acanthamoeba

Journal of Eukaryotic Microbiology

Volumn 53, Issue SUPPL. 1, 2006, Pages

  Marciano Cabral, Francine ^a   Raborn, Erinn S ^a   Martin, Billy R ^a   Cabral, Guy A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABIS; TETRAHYDROCANNABINOL;

CHEMICAL COMPOUND; CHEMOTAXIS; DRUG; PLANT EXTRACT; PROTOZOAN;

ACANTHAMOEBA; ANIMAL; ANIMAL MODEL; CELL MOTION; CHEMOTAXIS; CONFERENCE PAPER; DRUG EFFECT; FEMALE; IMMUNOLOGY; MOUSE; PERITONEUM MACROPHAGE; SCANNING ELECTRON MICROSCOPY;

ACANTHAMOEBA; ANIMALS; CANNABIS; CELL MOVEMENT; CHEMOTAXIS; FEMALE; MACROPHAGES, PERITONEAL; MICE; MICROSCOPY, ELECTRON, SCANNING; MODELS, ANIMAL; TETRAHYDROCANNABINOL;

ACANTHAMOEBA; CANNABIS; CANNABIS SATIVA;

EID: 33751374625     PISSN: 10665234     EISSN: 15507408     Source Type: Journal    
DOI: 10.1111/j.1550-7408.2006.00158.x     Document Type: Conference Paper

References (22)

1. Alfieri, S. C., Correia, C. E. B., Motegi, S. A. & Pral, E. M. F. 2000. Proteinase activities in total extracts and in medium conditioned by Acanthamoeba polyphaga trophozoites. J. Parasitol., 86:220-227.
2. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72:248-254.
3. Cabral, G. A. & Dove-Pettit, D. 1998. Drugs and immunity: cannabinoids and their role in decreased resistance to infectious diseases. J. Neuroimmunol., 83:116-123.
4. Cabral, G. A. & Staab, A. 2005. Effects on the immune system. In: Pertwee, R. (ed.), Handbook on Experimental Pharmacology: Cannabinoids. Springer-Verlag, Berlin. 168:385-423.
5. Felder, C. C., Dickason-Chesterfield, A. K. & Moore, S. A. 2006. Cannabinoids biology: the search for new therapeutic targets. Mol. Interv., 6:149-161.
6. Felder, C. C., Veluz, J. S., Williams, H.L, Briley, E. M. & Matsuda, L. A. 1992. Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones. Mol. Pharmacol., 42:838-845.
7. Hadas, E. & Mazur, T. 1993. Biochemical markers of pathogenicity and virulence of Acanthamoeba sp. strains. Parasitol. Res., 79:696-698.
8. Klein, T. W., Friedman, H. & Specter, S. 1998. Marijuana, immunity and infection. J. Neuroimmunol., 83:102-115.
9. 13C-NMR. Biochim. Biophys. Acta, 1028:31-42.
10. Marciano-Cabral, F. & Cabral, G. A. 2003. Acanthamoeba spp. as agents of disease in humans. Clin. Microbiol. Revs., 16:273-307.
11. Marciano-Cabral, F., Ferguson, T., Bradley, S. G. & Cabral, G. A. 2001. Delta-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, exacerbates brain infection by Acanthamoeba. J. Eukaryot. Microbiol., 48:4S-5S.
12. Marciano-Cabral, F. & Toney, D. T. 1998. The interaction of Acanthamoeba spp. with activated macrophages and with macrophage cell lines. J. Eukaryot. Microbiol., 45:452-458.
13. Martinez, A. J. & Visvesvara, G. S. 1997. Free-living, amphizoic and opportunistic amebas. Brain Pathol., 7:583-598.
14. Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C. & Bonner, T. I. 1990. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature, 346:561-564.
15. Mitra, M. M., Alizadeh, H., Gerard, R. D. & Niederkorn, J. Y. 1995. Characterization of a plasminogen activator produced by Acanthamoeba castellanii. Mol. Biochem. Parasitol., 73:157-164.
16. Munro, S., Thomas, K. L. & Abu-Shaar, M. 1993. Molecular characterization of a peripheral receptor for cannabinoids. Nature, 365:61-65.
17. Paltiel, M., Powell, E., Lynch, J., Baranowski, B. & Martins, C. 2004. Disseminated cutaneous acanthamebiasis: a case report and review of the literature. Cutis, 73:241-248.
18. Pettit, D. A., Williamson, J., Cabral, G. A. & Marciano-Cabral, F. 1996. In vitro destruction of nerve cell cultures by Acanthamoeba spp.: a transmission and scanning electron microscopy study. J. Parasitol., 82:769-777.
19. Robson, P. 2005. Human studies of cannabinoids and medicinal cannabis. Handb. Exp. Pharmacol., 168:719-756.
20. de Serrano-Luna, J, Cervantes-Sandoval, I., Calderon, J., Navarro-Garcia, F., Tsutsumi, V. & Shibayama, M. 2006. Protease activities of Acanthamoeba polyphaga and Acanthamoeba castellanii. Can. J. Microbiol., 52:16-23.
21. Sissons, J., Alsam, S., Goldsworthy, G., Lightfoot, M., Jarroll, E. L. & Khan, N. A. 2006. Identification and properties of proteases from an Acanthamoeba isolate capable of producing granulomatous encephalitis. B. M. C. Microbiol., 6:42.
22. Van Klink, F., Taylor, W. M., Alizadeh, H., Jager, M. J., van Rooijen, N. & Niederkorn, J. Y. 1996. The role of macrophages in Acanthamoeba keratitis. Invest. Ophthalmol. Vis. Sci., 7:1271-1281.