Prevalence of DHPS polymorphisms associated with sulfa resistance in South African Pneumocystis jirovecii strains

Journal of Eukaryotic Microbiology

Volumn 53, Issue SUPPL. 1, 2006, Pages

  Dini, Leigh ^a   Du Plessis, Mignon ^a   Wong, Michelle ^b   Karstaedt, Alan ^b   Fernandez, Victor ^c   Frean, John ^a  

^a NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DIHYDROPTEROATE SYNTHASE; FUNGAL DNA; FUNGAL PROTEIN; SULFANILAMIDE DERIVATIVE;

FUNGUS; POLYMORPHISM;

ADULT; AIDS RELATED COMPLEX; ANTIBIOTIC RESISTANCE; CONFERENCE PAPER; DNA SEQUENCE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC POLYMORPHISM; GENETICS; HOSPITAL; HUMAN; ISOLATION AND PURIFICATION; MALE; MICROBIOLOGY; MUTATION; PNEUMOCYSTIS JIROVECI; PNEUMOCYSTIS PNEUMONIA; POLYMERASE CHAIN REACTION; PREVALENCE; SOUTH AFRICA; SPUTUM;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTI-INFECTIVE AGENTS; DIHYDROPTEROATE SYNTHASE; DNA, FUNGAL; DRUG RESISTANCE, FUNGAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; FUNGAL PROTEINS; HOSPITALS; HUMANS; MALE; MUTATION; PNEUMOCYSTIS JIROVECI; PNEUMONIA, PNEUMOCYSTIS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PREVALENCE; SEQUENCE ANALYSIS, DNA; SOUTH AFRICA; SPUTUM; SULFANILAMIDES;

AFRICA; SOUTH AFRICA; SOUTHERN AFRICA; SUB-SAHARAN AFRICA;

PNEUMOCYSTIS JIROVECII;

EID: 33751374478     PISSN: 10665234     EISSN: 15507408     Source Type: Journal    
DOI: 10.1111/j.1550-7408.2006.00193.x     Document Type: Conference Paper

References (15)

1. Beard, C. B., Carter, J., Keely, S. P., Huang, L., Pieniazek, N. J., Moura, I. N. S., Roberts, J. M., Hightower, A. W., Bens, M. S., Freeman, A. R., Lee, S., Stringer, J. R., Duchin, J. S., del Rio, C., Rimland, D., Baughman, R. P., Levy, D. A., Dietz, V. J., Simon, P. & Navin, T. R. 2000. Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission. Emerg. Infect. Dis., 6:265-272.
2. Brooks, D. R., Wang, P., Read, M., Watkins, W. M., Sims, P. F. & Hyde, J. E. 1994. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur. J. Biochem., 224:397-405.
3. Crewe-Brown, H. H., Reyneke, M. P., Khoosal, M., Becker, P. J. & Karstaedt, A. S. 2004. Increase in trimethoprim-sulfamethoxazole (co-trimoxazole) resistance at Chris Hani Baragwanath hospital, Soweto, in the AIDS era. S. Afr. Med. J., 94:440-442.
4. Dallas, W. S., Gowen, J. E., Ray, P. H., Cox, M. J. & Dev, I. K. 1992. Cloning, sequencing and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100. J. Bacteriol., 174:5961-5970.
5. Department of Health. 2006. National HIV and Syphilis Prevalence Survey South Africa 2005. National Department of Health, Pretoria. p. 10-11.
6. Helweg-Larsen, J., Benfield, T. L., Eugen-Olsen, J., Lundgren, J. D. & Lundgren, B. 1999. Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia. Lancet, 354:1318-1351.
7. Huang, L., Beard, C. B., Creasman, J., Levy, D., Duchin, J. S., Lee, S., Pieniazek, N., Carter, J., del Rio, C., Rimland, D. & Navin, T. R. 2000. Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene. J. Infect. Dis., 182:1192-1198.
8. Kazanjian, P., Armstrong, W., Hossler, P. A., Burman, W., Richardson, J., Lee, C. H., Crane, L., Katz, J. & Meshnick, S. R. 2000. Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patients. J. Infect. Dis., 182:551-557.
9. Ma, L., Borio, L. & Masur, H. 1999. Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use. J. Infect. Dis., 180:1969-1978.
10. Madhi, S. A., Ludewick, H., Abed, Y., Klugman, K. P. & Boivin, G. 2003. Human metapneumovirus-associated lower respiratory tract infections among hospitalized human immunodeficiency virus type 1 (HIV-1)-infected and HIV-1-uninfected African infants. Clin. Infect. Dis., 37:1705-1710.
11. Nahimana, A., Rabodonirina, M., Helweg-Larsen, J., Meneau, I., Francioli, P., Bille, J. & Hauser, P. M. 2003. Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia. Emerg. Infect. Dis., 9:864-867.
12. Robberts, F. J. L., Chalkley, L. J., Weyer, K., Goussard, P. & Liebowitz, L. D. 2005. Dihydropteroate synthase and novel dihydrofolate reductase gene mutations in strains of Pneumocystis jirovecii from South Africa. J. Clin. Microbiol., 43:1443-1444.
13. UNAIDS/UNICEF/USAID. 2004. A Joint Report of New Orphan Estimates and a Framework for Action. UNICEF, New York. p. 26.
14. Zar, H. J., Alvarez-Martinez, M. J., Harrison, A. & Meshnick, S. R. 2004. Prevalence of dihydropteroate synthase mutants in HIV-infected South African children with Pneumocystis jirovecii pneumonia. Clin. Infect. Dis., 39:1047-1051.
15. Zingale, A., Carrera, P., Lazzarin, A. & Scarpellini, P. 2003. Detection of Pneumocystis carinii and characterization of mutations associated with sulfa resistance in bronchoalveolar lavage samples from human immunodeficiency virus-infected subjects. J. Clin. Microbiol., 41:2709-2712.