-
1
-
-
4344569251
-
Mitoxantrone therapy in multiple sclerosis and acute leukaemia: A case report out of 644 treated patients
-
Voltz R, Starck M, Zingler V, Strupp M, Kolb HJ: Mitoxantrone therapy in multiple sclerosis and acute leukaemia: a case report out of 644 treated patients. Mult Scler 2004;10:472-474.
-
(2004)
Mult Scler
, vol.10
, pp. 472-474
-
-
Voltz, R.1
Starck, M.2
Zingler, V.3
Strupp, M.4
Kolb, H.J.5
-
2
-
-
0001208259
-
Condensation of nucleic acids by intercalating aromatic cations
-
Kapuscinski J, Darzynkiewicz Z: Condensation of nucleic acids by intercalating aromatic cations. Proc Natl Acad Sci USA 1984;81:7368-7372.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 7368-7372
-
-
Kapuscinski, J.1
Darzynkiewicz, Z.2
-
3
-
-
0025052143
-
Long-term inhibition of DNA synthesis and the persistence of trapped topoisomerase II complexes in determining the toxicity of the antitumor DNA intercalators mAMSA and mitoxantrone
-
Fox ME, Smith PJ: Long-term inhibition of DNA synthesis and the persistence of trapped topoisomerase II complexes in determining the toxicity of the antitumor DNA intercalators mAMSA and mitoxantrone. Cancer Res 1990;50:813-818.
-
(1990)
Cancer Res
, vol.50
, pp. 813-818
-
-
Fox, M.E.1
Smith, P.J.2
-
4
-
-
0022635318
-
Selective immunomodulation by the antineoplastic agent mitoxantrone. 2. Nonspecific adherent suppressor cell derived from mitoxantrone-treated mice
-
Fidler JM, DeJoy SQ, Smith FR 3rd, Gibbons JJ Jr: Selective immunomodulation by the antineoplastic agent mitoxantrone. 2. Nonspecific adherent suppressor cell derived from mitoxantrone-treated mice. J Immunol 1986;136:2747-2754.
-
(1986)
J Immunol
, vol.136
, pp. 2747-2754
-
-
Fidler, J.M.1
DeJoy, S.Q.2
Smith III, F.R.3
Gibbons Jr., J.J.4
-
5
-
-
0022450390
-
Selective immunomodulation by the antineoplastic agent mitoxantrone. 1. Suppression of B lymphocyte function
-
Fidler JM, DeJoy SQ, Gibbons JJ Jr: Selective immunomodulation by the antineoplastic agent mitoxantrone. 1. Suppression of B lymphocyte function. J Immunol 1986;137:727-732.
-
(1986)
J Immunol
, vol.137
, pp. 727-732
-
-
Fidler, J.M.1
DeJoy, S.Q.2
Gibbons Jr., J.J.3
-
6
-
-
0037232745
-
Effects of mitoxantrone on multiple sclerosis patients' lymphocyte subpopulations and production of immunoglobulin, TNF-alpha and IL-10
-
Gbadamosi J, Buhmann C, Tessmer W, Moench A, Haag F, Heesen C: Effects of mitoxantrone on multiple sclerosis patients' lymphocyte subpopulations and production of immunoglobulin, TNF-alpha and IL-10. Eur Neurol 2003;49:137-141.
-
(2003)
Eur Neurol
, vol.49
, pp. 137-141
-
-
Gbadamosi, J.1
Buhmann, C.2
Tessmer, W.3
Moench, A.4
Haag, F.5
Heesen, C.6
-
7
-
-
0027261147
-
The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents
-
Gorczyca W, Gong J, Ardelt B, Traganos F, Darzynkiewicz Z: The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res 1993;53:3186-3192.
-
(1993)
Cancer Res
, vol.53
, pp. 3186-3192
-
-
Gorczyca, W.1
Gong, J.2
Ardelt, B.3
Traganos, F.4
Darzynkiewicz, Z.5
-
8
-
-
0000185988
-
Immunosuppression with mitoxantrone in multiple sclerosis: A pilot study for 2 years in 22 patients
-
Gonsette RE, Demonty L: Immunosuppression with mitoxantrone in multiple sclerosis: a pilot study for 2 years in 22 patients. Neurology 1990;40(suppl 1):261.
-
(1990)
Neurology
, vol.40
, Issue.SUPPL. 1
, pp. 261
-
-
Gonsette, R.E.1
Demonty, L.2
-
9
-
-
0000185991
-
Mitoxantrone (MX) in the treatment of rapidly progressive multiple sclerosis: A pilot study with serial gadolinium (GD)-enhanced MRI
-
Kappos L, Gold R, Künstler E, Rohrbach E, Heun R, Städt D, Hofmann E: Mitoxantrone (MX) in the treatment of rapidly progressive multiple sclerosis: a pilot study with serial gadolinium (GD)-enhanced MRI. Neurology 1990;49(suppl 1):261.
-
(1990)
Neurology
, vol.49
, Issue.SUPPL. 1
, pp. 261
-
-
Kappos, L.1
Gold, R.2
Künstler, E.3
Rohrbach, E.4
Heun, R.5
Städt, D.6
Hofmann, E.7
-
10
-
-
0012946055
-
A phase II evaluation of mitoxantrone HCI in the treatment of progressive multiple sclerosis
-
Noseworthy JH, Lee D, Penman M, Hopkins M, Vandervoort MK, Karlik SJ, Rice GPA, Grinwich KD, Ebers GC: A phase II evaluation of mitoxantrone HCI in the treatment of progressive multiple sclerosis. Neurology 1991;41(suppl):146.
-
(1991)
Neurology
, vol.41
, Issue.SUPPL.
, pp. 146
-
-
Noseworthy, J.H.1
Lee, D.2
Penman, M.3
Hopkins, M.4
Vandervoort, M.K.5
Karlik, S.J.6
Rice, G.P.A.7
Grinwich, K.D.8
Ebers, G.C.9
-
11
-
-
0027225747
-
An open-trial evaluation of mitoxantrone in the treatment of progressive MS
-
Noseworthy JH, Hopkins MB, Vandervoort MK, Karlik SJ, Lee DH, Penman M, Rice GP, Grinwich KD, Cauvier H, Harris BJ: An open-trial evaluation of mitoxantrone in the treatment of progressive MS. Neurology 1993;43:1401-1406.
-
(1993)
Neurology
, vol.43
, pp. 1401-1406
-
-
Noseworthy, J.H.1
Hopkins, M.B.2
Vandervoort, M.K.3
Karlik, S.J.4
Lee, D.H.5
Penman, M.6
Rice, G.P.7
Grinwich, K.D.8
Cauvier, H.9
Harris, B.J.10
-
12
-
-
0027068815
-
Treatment of multiple sclerosis with mitoxantrone
-
Mauch E, Kornhuber HH, Krapf H, Fetzer U, Laufen H: Treatment of multiple sclerosis with mitoxantrone. Eur Arch Psychiatry Clin Neurosci 1992;242:96-102.
-
(1992)
Eur Arch Psychiatry Clin Neurosci
, vol.242
, pp. 96-102
-
-
Mauch, E.1
Kornhuber, H.H.2
Krapf, H.3
Fetzer, U.4
Laufen, H.5
-
13
-
-
0027133024
-
Immunosuppressive therapy of multiple sclerosis with mitoxantrone
-
Mauch E, Kornhuber HH: Immunosuppressive therapy of multiple sclerosis with mitoxantrone. Fortschr Neurol Psychiatry 1993;61:410-417.
-
(1993)
Fortschr Neurol Psychiatry
, vol.61
, pp. 410-417
-
-
Mauch, E.1
Kornhuber, H.H.2
-
14
-
-
0028796522
-
Serial gadolinium-enhanced magnetic resonance imaging in patients with multiple sclerosis treated with mitoxantrone
-
Krapf H, Mauch E, Fetzer U, Laufen H, Kornhuber HH: Serial gadolinium-enhanced magnetic resonance imaging in patients with multiple sclerosis treated with mitoxantrone. Neuroradiology 1995;37:113-119.
-
(1995)
Neuroradiology
, vol.37
, pp. 113-119
-
-
Krapf, H.1
Mauch, E.2
Fetzer, U.3
Laufen, H.4
Kornhuber, H.H.5
-
15
-
-
0031040238
-
Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: A randomised multicentre study of active disease using MRI and clinical criteria
-
Edan G, Miller D, Clanet M, Confavreux C, Lyon-Caen O, Lubetzki C, Brochet B, Berry I, Rolland Y, Froment JC, Cabanis E, Iba-Zizen MT, Gandon JM, Lai HM, Moseley I, Sabouraud O: Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomised multicentre study of active disease using MRI and clinical criteria. J Neurol Neurosurg Psychiatry 1997;62:112-118.
-
(1997)
J Neurol Neurosurg Psychiatry
, vol.62
, pp. 112-118
-
-
Edan, G.1
Miller, D.2
Clanet, M.3
Confavreux, C.4
Lyon-Caen, O.5
Lubetzki, C.6
Brochet, B.7
Berry, I.8
Rolland, Y.9
Froment, J.C.10
Cabanis, E.11
Iba-Zizen, M.T.12
Gandon, J.M.13
Lai, H.M.14
Moseley, I.15
Sabouraud, O.16
-
16
-
-
0027968510
-
A controlled trial of mitoxantrone in multiple sclerosis: Serial MRI evaluation at one year
-
Bastianello S, Pozzilli C, D'Andrea F, Millefiorini E, Trojano M, Morino S, Gasperini C, Bozzao A, Gallucci M, Andreula C, Bozzao L, Gambi D, Prencipe M: A controlled trial of mitoxantrone in multiple sclerosis: serial MRI evaluation at one year. Can J Neurol Sci 1994;21:266-270.
-
(1994)
Can J Neurol Sci
, vol.21
, pp. 266-270
-
-
Bastianello, S.1
Pozzilli, C.2
D'Andrea, F.3
Millefiorini, E.4
Trojano, M.5
Morino, S.6
Gasperini, C.7
Bozzao, A.8
Gallucci, M.9
Andreula, C.10
Bozzao, L.11
Gambi, D.12
Prencipe, M.13
-
17
-
-
8044242916
-
Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-Month clinical and MRI outcome
-
Millefiorini E, Gasperini C, Pozzilli C, D'Andrea F, Bastianello S, Trojano M, Morino S, Morra VB, Bozzao A, Calo A, Bernini ML, Gambi D, Prencipe M: Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome. J Neurol 1997;244:153-159.
-
(1997)
J Neurol
, vol.244
, pp. 153-159
-
-
Millefiorini, E.1
Gasperini, C.2
Pozzilli, C.3
D'Andrea, F.4
Bastianello, S.5
Trojano, M.6
Morino, S.7
Morra, V.B.8
Bozzao, A.9
Calo, A.10
Bernini, M.L.11
Gambi, D.12
Prencipe, M.13
-
18
-
-
0037153729
-
Mitoxantrone in progressive multiple sclerosis: A placebo-controlled, double-blind, randomised, multicentre trial
-
Mitoxantrone in Multiple Sclerosis Study Group (MIMS)
-
Hartung HP, Gonsette R, Konig N, Kwiecinski H, Guseo A, Morrissey SP, Krapf H, Zwingers T, Mitoxantrone in Multiple Sclerosis Study Group (MIMS): Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomised, multicentre trial. Lancet 2002;360:2018-2025.
-
(2002)
Lancet
, vol.360
, pp. 2018-2025
-
-
Hartung, H.P.1
Gonsette, R.2
Konig, N.3
Kwiecinski, H.4
Guseo, A.5
Morrissey, S.P.6
Krapf, H.7
Zwingers, T.8
-
19
-
-
24644485224
-
Effect of mitoxantrone on MRI in progressive MS: Results of the MIMS trial
-
MIMS Study Group
-
Krapf H, Morrissey SP, Zenker O, Zwingers T, Gonsette R, Hartung HP, MIMS Study Group: Effect of mitoxantrone on MRI in progressive MS: results of the MIMS trial. Neurology 2005;65:690-695.
-
(2005)
Neurology
, vol.65
, pp. 690-695
-
-
Krapf, H.1
Morrissey, S.P.2
Zenker, O.3
Zwingers, T.4
Gonsette, R.5
Hartung, H.P.6
-
20
-
-
10944258663
-
Review of mitoxantrone in the treatment of multiple sclerosis
-
Jeffery DR, Herndon R: Review of mitoxantrone in the treatment of multiple sclerosis. Neurology 2004;63(suppl 6):S19-S24.
-
(2004)
Neurology
, vol.63
, Issue.SUPPL. 6
-
-
Jeffery, D.R.1
Herndon, R.2
-
21
-
-
11244349904
-
Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients
-
Chan A, Weilbach FX, Toyka KV, Gold R: Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients. Clin Exp Immunol 2005;139:152-158.
-
(2005)
Clin Exp Immunol
, vol.139
, pp. 152-158
-
-
Chan, A.1
Weilbach, F.X.2
Toyka, K.V.3
Gold, R.4
-
22
-
-
20444434782
-
Multiple sclerosis: Mitoxantrone promotes differential effects on immunocompetent cells in vitro
-
Neuhaus O, Wiendl H, Kieseier BC, Archelos JJ, Hemmer B, Stuve O, Hartung HP: Multiple sclerosis: mitoxantrone promotes differential effects on immunocompetent cells in vitro. J Neuroimmunol 2005;168:128-137.
-
(2005)
J Neuroimmunol
, vol.168
, pp. 128-137
-
-
Neuhaus, O.1
Wiendl, H.2
Kieseier, B.C.3
Archelos, J.J.4
Hemmer, B.5
Stuve, O.6
Hartung, H.P.7
-
23
-
-
0034284130
-
Cytokines and immunity in multiple sclerosis: The dual signal hypothesis
-
Martino G, Furlan R, Brambilla E, Bergami A, Ruffini F, Gironi M, Poliani PL, Grimaldi LM, Comi G: Cytokines and immunity in multiple sclerosis: the dual signal hypothesis. J Neuroimmunol 2000;109:3-9.
-
(2000)
J Neuroimmunol
, vol.109
, pp. 3-9
-
-
Martino, G.1
Furlan, R.2
Brambilla, E.3
Bergami, A.4
Ruffini, F.5
Gironi, M.6
Poliani, P.L.7
Grimaldi, L.M.8
Comi, G.9
-
24
-
-
0041677606
-
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
-
Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F: Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003;374:1-20.
-
(2003)
Biochem J
, vol.374
, pp. 1-20
-
-
Heinrich, P.C.1
Behrmann, I.2
Haan, S.3
Hermanns, H.M.4
Müller-Newen, G.5
Schaper, F.6
-
25
-
-
0032975730
-
Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis
-
Van Boxel-Dezaire AH, Hoff SC, van Oosten BW, Verweij CL, Drager AM, Ader HJ, van Houwelingen JC, Barkhof F, Polman CH, Nagelkerken L: Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis. Ann Neurol 1999;45:695-703.
-
(1999)
Ann Neurol
, vol.45
, pp. 695-703
-
-
Van Boxel-Dezaire, A.H.1
Hoff, S.C.2
Van Oosten, B.W.3
Verweij, C.L.4
Drager, A.M.5
Ader, H.J.6
Van Houwelingen, J.C.7
Barkhof, F.8
Polman, C.H.9
Nagelkerken, L.10
-
26
-
-
3042658620
-
Increased blood plasma concentrations of TGF-beta isoforms after treatment with intravenous immunoglobulins (ivIG) in patients with multiple sclerosis
-
Reinhold D, Perlov E, Schrecke K, Kekow J, Brune T, Sailer M: Increased blood plasma concentrations of TGF-beta isoforms after treatment with intravenous immunoglobulins (ivIG) in patients with multiple sclerosis. J Neuroimmunol 2004;152:191-194.
-
(2004)
J Neuroimmunol
, vol.152
, pp. 191-194
-
-
Reinhold, D.1
Perlov, E.2
Schrecke, K.3
Kekow, J.4
Brune, T.5
Sailer, M.6
-
27
-
-
10944231932
-
Mechanism of action of mitoxantrone
-
Fox EJ: Mechanism of action of mitoxantrone. Neurology 2004;63(suppl 6):S15-S18.
-
(2004)
Neurology
, vol.63
, Issue.SUPPL. 6
-
-
Fox, E.J.1
-
28
-
-
0030964023
-
Interleukin-6 (IL-6) - A molecule with both beneficial and destructive potentials
-
Gadient RA, Otten UH: Interleukin-6 (IL-6) - A molecule with both beneficial and destructive potentials. Prog Neurobiol 1997;52:379-390.
-
(1997)
Prog Neurobiol
, vol.52
, pp. 379-390
-
-
Gadient, R.A.1
Otten, U.H.2
-
29
-
-
0036694589
-
IL-6 in autoimmune disease and chronic inflammatory proliferative disease
-
Ishihara K, Hirano T: IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev 2002;13:357-368.
-
(2002)
Cytokine Growth Factor Rev
, vol.13
, pp. 357-368
-
-
Ishihara, K.1
Hirano, T.2
-
30
-
-
0032700063
-
IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glucoprotein 35-55 induced experimental autoimmune encephalomyelitis
-
Okuda Y, Sakoda S, Fujimura H, Saeki Y, Kishimoto T, Yanagihara T: IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glucoprotein 35-55 induced experimental autoimmune encephalomyelitis. J Neuroimmunol 1999;101:188-196.
-
(1999)
J Neuroimmunol
, vol.101
, pp. 188-196
-
-
Okuda, Y.1
Sakoda, S.2
Fujimura, H.3
Saeki, Y.4
Kishimoto, T.5
Yanagihara, T.6
-
31
-
-
0034717832
-
Enhancement of Th2 response in IL-6-deficient mice immunized with myelin oligodendrocyte glycoprotein
-
Okuda Y, Sakoda S, Saeki Y, Kishimoto T, Yanagihara T: Enhancement of Th2 response in IL-6-deficient mice immunized with myelin oligodendrocyte glycoprotein. J Neuroimmunol 2000;105:120-123.
-
(2000)
J Neuroimmunol
, vol.105
, pp. 120-123
-
-
Okuda, Y.1
Sakoda, S.2
Saeki, Y.3
Kishimoto, T.4
Yanagihara, T.5
-
32
-
-
0036695207
-
The role of interleukin-10 in autoimmune disease: Systemic lupus erythematosus (SLE) and multiple sclerosis (MS)
-
Beebe AM, Cua DJ, de Waal Malefyt R: The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Cytokine Growth Factor Rev 2002;13:403-412.
-
(2002)
Cytokine Growth Factor Rev
, vol.13
, pp. 403-412
-
-
Beebe, A.M.1
Cua, D.J.2
De Waal Malefyt, R.3
-
34
-
-
5144227225
-
Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: A dialogue with microglia
-
Kipnis J, Avidan H, Caspi RR, Schwartz M: Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: a dialogue with microglia. Proc Natl Acad Sci USA 2004;101:14663-14669.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 14663-14669
-
-
Kipnis, J.1
Avidan, H.2
Caspi, R.R.3
Schwartz, M.4
|