Prenatally diagnosable differences in the cellular immunity of fetuses with Down's and Edwards' syndrome

Fetal Diagnosis and Therapy

Volumn 21, Issue 6, 2006, Pages 510-514

  Zizka, Zdenek ^a,b   Calda, Pavel ^a   Fait, Tomas ^a   Haakova, Lucia ^a   Kvasnicka, Jan ^a   Viskova, Hana ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

CD markers; Cordocentesis; Down's syndrome; Edwards' syndrome; Lymphocyte subpopulations

Indexed keywords

CD16 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD5 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; MONOCLONAL ANTIBODY;

ADULT; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELLULAR IMMUNITY; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORDOCENTESIS; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; DOWN SYNDROME; EDWARDS SYNDROME; FEMALE; FETUS; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; KARYOTYPE; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; MONOCYTE; NATURAL KILLER CELL; PREGNANT WOMAN; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; SECOND TRIMESTER PREGNANCY; T CELL DEPLETION;

ADULT; ANTIGENS, CD; B-LYMPHOCYTES; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 18; CHROMOSOMES, HUMAN, PAIR 21; CORDOCENTESIS; DOWN SYNDROME; FEMALE; GESTATIONAL AGE; HUMANS; IMMUNITY, CELLULAR; KILLER CELLS, NATURAL; LYMPHOCYTE SUBSETS; MIDDLE AGED; PREGNANCY; PRENATAL DIAGNOSIS; SYNDROME; T-LYMPHOCYTES; TRISOMY;

EID: 33751348519     PISSN: 10153837     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095663     Document Type: Article

References (11)

1. Hannet I, Erkeller-Yuksel F, Lydyard P, et al: Developmental and maturation changes in human blood lymphocyte subpopulations. Immunol Today 1992;13:215-218.
2. Zhao Y, Dai ZP, Lv P, Gao XM: Phenotypic and functional analysis of human T lymphocytes in early second- and third-trimester fetuses. Clin Exp Immunol 2002;129:302-308.
3. Kral V, Bartunkova J, Svorc, et al: Prvni pripad syndromu deficience leukocytarnich integrinu v Ceskérepublice a uspesna prenatalni diagnostika v postizene rodine. Cas Lek Ces 1996;135:154-158.
4. D'Arena G, Musto P, Cascavilla A, et al: Flow cytometric characterization of human umbilical cord blood lymphocytes: immunophenotypic features. Haematologica 1998;83:197-203.
5. Fuentes JJ, Genesca L, Kingsbury TJ, et al: DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet 2000;9:1681-1690.
6. Sustrova M, Sarikova V: Downuv syndrom - dosledky zvysenej expresie genov 21. chromozomu na funkciu imunitneho a nervoveho systemu. Bratisl Lek Listy 1997;98:221-228.
7. Park E, Alberti J, Mehta P, et al: Partial impairment of immune functions in peripheral blood leukocytes from aged men with Down's syndrome. Clin Immunol 2000;95:62-69.
8. Epstein LB: The consequences of chromosomal imbalance;in: Epstein C (ed): Principles Mechanism Models. New York, Cambridge University Press, 1986, pp s1-s50.
9. Thilaganathan B, Tsakonas D, Nicolaides K: Abnormal fetal immunological development in Down syndrome. Br J Obstet Gynaecol 1993;100:60-62.
10. Makrydimas G, Plachouras N, Thilaganathan B, et al: Abnormal immunological development in fetuses with trisomy 18. Prenat Diagn 1994;14:239-241.
11. Kola I, Hertzog PJ: Animal models in the study of the biological function of genes on human chromosome 21 and their role in the pathophysiology of Down syndrome. Hum Mol Genet 1997;6:1713-1727.