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Volumn 20, Issue 6, 2006, Pages 891-893

Con: Antifibrinolytics Are Not Safe and Effective in Patients Undergoing Liver Transplantation

Author keywords

antifibrinolytics; aprotinin; epsilon aminocaproic acid; fibrinolysis; liver failure; liver transplantation; patient safety; thrombosis; tranexamic acid

Indexed keywords


EID: 33751347630     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2006.07.007     Document Type: Note
Times cited : (12)

References (34)
  • 1
    • 4544373091 scopus 로고    scopus 로고
    • Hemostatic disorders in liver diseases
    • Schiff E.R., Sorrell M.F., Maddrey W.C., et al. (Eds), Lippincott Williams & Wilkins, Philadelphia, PA
    • Hedner U., and Erhardtsen E. Hemostatic disorders in liver diseases. In: Schiff E.R., Sorrell M.F., Maddrey W.C., et al. (Eds). Schiff's Diseases of the Liver (2003), Lippincott Williams & Wilkins, Philadelphia, PA 2003
    • (2003) Schiff's Diseases of the Liver , pp. 2003
    • Hedner, U.1    Erhardtsen, E.2
  • 2
    • 0038798847 scopus 로고    scopus 로고
    • Deficiency of thrombin-activatable fibrinolysis inhibitor in cirrhosis is associated with increased fibrinolysis
    • Colucci M., Binetti B.M., Branca M.G., et al. Deficiency of thrombin-activatable fibrinolysis inhibitor in cirrhosis is associated with increased fibrinolysis. Hepatology 38 (2003) 230-237
    • (2003) Hepatology , vol.38 , pp. 230-237
    • Colucci, M.1    Binetti, B.M.2    Branca, M.G.3
  • 3
    • 0022589301 scopus 로고
    • Hemostatic problems in liver disease
    • Kelly D.A., and Tuddenham E.G. Hemostatic problems in liver disease. Gut 27 (1986) 339-349
    • (1986) Gut , vol.27 , pp. 339-349
    • Kelly, D.A.1    Tuddenham, E.G.2
  • 4
    • 0023258158 scopus 로고
    • The pathogenesis of accelerated fibrinolysis in liver cirrhosis: A critical role for tissue plasminogen activator inhibitor
    • Hersch S.L., Kunelis T., and Francis R.B. The pathogenesis of accelerated fibrinolysis in liver cirrhosis: A critical role for tissue plasminogen activator inhibitor. Blood 69 (1987) 1315-1319
    • (1987) Blood , vol.69 , pp. 1315-1319
    • Hersch, S.L.1    Kunelis, T.2    Francis, R.B.3
  • 5
    • 14244256300 scopus 로고    scopus 로고
    • Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests
    • Tripodi A., Salerno F., Chantarangkul F., et al. Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. Hepatology 41 (2005) 553-558
    • (2005) Hepatology , vol.41 , pp. 553-558
    • Tripodi, A.1    Salerno, F.2    Chantarangkul, F.3
  • 6
    • 14244260492 scopus 로고    scopus 로고
    • The coagulopathy of cirrhosis: Myth or reality
    • Bosch J., and Reverter J.C. The coagulopathy of cirrhosis: Myth or reality. Hepatology 41 (2005) 434-435
    • (2005) Hepatology , vol.41 , pp. 434-435
    • Bosch, J.1    Reverter, J.C.2
  • 7
    • 0021815571 scopus 로고
    • Intraoperative changes in blood coagulation and thromboelastographic monitoring in liver transplantation
    • Kang Y.G., Martin D.J., Marquez J., et al. Intraoperative changes in blood coagulation and thromboelastographic monitoring in liver transplantation. Anesth Analg 64 (1985) 888-896
    • (1985) Anesth Analg , vol.64 , pp. 888-896
    • Kang, Y.G.1    Martin, D.J.2    Marquez, J.3
  • 8
    • 0031041434 scopus 로고    scopus 로고
    • Hypercoagulability in patients with primary biliary cirrhosis and primary sclerosing cholangitis evaluated by thromboelastography
    • Ben-Ari Z., Panagou M., Patch D., et al. Hypercoagulability in patients with primary biliary cirrhosis and primary sclerosing cholangitis evaluated by thromboelastography. J Hepatol 26 (1997) 554-559
    • (1997) J Hepatol , vol.26 , pp. 554-559
    • Ben-Ari, Z.1    Panagou, M.2    Patch, D.3
  • 9
    • 0037369783 scopus 로고    scopus 로고
    • Thrombotic risk factors and extent of liver fibrosis in chronic viral hepatitis
    • Papatheodoridis G.V., Papakonstantinou E., Andrioti E., et al. Thrombotic risk factors and extent of liver fibrosis in chronic viral hepatitis. Gut 52 (2003) 404-409
    • (2003) Gut , vol.52 , pp. 404-409
    • Papatheodoridis, G.V.1    Papakonstantinou, E.2    Andrioti, E.3
  • 10
    • 0022453610 scopus 로고
    • Portal thrombosis in cirrhotics: A retrospective analysis
    • Belli L., Romani F., Sansalone C.V., et al. Portal thrombosis in cirrhotics: A retrospective analysis. Ann Surg 203 (1986) 286-291
    • (1986) Ann Surg , vol.203 , pp. 286-291
    • Belli, L.1    Romani, F.2    Sansalone, C.V.3
  • 11
    • 0024413449 scopus 로고
    • Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation
    • Porte R.J., Bontempo F.A., Knot E.A., et al. Systemic effects of tissue plasminogen activator-associated fibrinolysis and its relation to thrombin generation in orthotopic liver transplantation. Transplantation 47 (1989) 978-984
    • (1989) Transplantation , vol.47 , pp. 978-984
    • Porte, R.J.1    Bontempo, F.A.2    Knot, E.A.3
  • 12
    • 0027971861 scopus 로고
    • Predictive factors of hyperfibrinolytic activity during liver transplantation in cirrhotic patients
    • Steib A., Gengenwin N., Freys G., et al. Predictive factors of hyperfibrinolytic activity during liver transplantation in cirrhotic patients. Br J Anaesth 73 (1994) 645-648
    • (1994) Br J Anaesth , vol.73 , pp. 645-648
    • Steib, A.1    Gengenwin, N.2    Freys, G.3
  • 13
    • 0031265843 scopus 로고    scopus 로고
    • Transfusion based on clinical coagulation monitoring does reduce hemorrhage during liver transplantation
    • Kang Y. Transfusion based on clinical coagulation monitoring does reduce hemorrhage during liver transplantation. Liver Transpl Surg 3 (1997) 655-659
    • (1997) Liver Transpl Surg , vol.3 , pp. 655-659
    • Kang, Y.1
  • 14
    • 0029861942 scopus 로고    scopus 로고
    • Tranexemic acid reduces blood loss, transfusion requirements, and coagulation factor use in primary orthotopic liver transplantation
    • Boylan J.F., Klinck J.R., Sandler A.N., et al. Tranexemic acid reduces blood loss, transfusion requirements, and coagulation factor use in primary orthotopic liver transplantation. Anesthesiology 85 (1996) 1043-1048
    • (1996) Anesthesiology , vol.85 , pp. 1043-1048
    • Boylan, J.F.1    Klinck, J.R.2    Sandler, A.N.3
  • 15
    • 0023252175 scopus 로고
    • Epsilon-aminocaproic acid for treatment of fibrinolysis during liver transplantation
    • Kang Y., Lewis J.H., Navalgund A., et al. Epsilon-aminocaproic acid for treatment of fibrinolysis during liver transplantation. Anesthesiology 66 (1987) 7766-7773
    • (1987) Anesthesiology , vol.66 , pp. 7766-7773
    • Kang, Y.1    Lewis, J.H.2    Navalgund, A.3
  • 16
    • 0030695217 scopus 로고    scopus 로고
    • The use of antifibrinolytic agents results in a reduction in transfused blood products during liver transplantation
    • Ramsay M.A.E. The use of antifibrinolytic agents results in a reduction in transfused blood products during liver transplantation. Liver Transpl Surg 3 (1997) 665-674
    • (1997) Liver Transpl Surg , vol.3 , pp. 665-674
    • Ramsay, M.A.E.1
  • 17
    • 0030799952 scopus 로고    scopus 로고
    • Continuous small-dose tranexemic acid reduces fibrinolysis but not transfusion requirements during orthotopic liver transplantation
    • Kaspar M., Ramsay M.A.E., Nguyen A.T., et al. Continuous small-dose tranexemic acid reduces fibrinolysis but not transfusion requirements during orthotopic liver transplantation. Anesth Analg 85 (1997) 281-285
    • (1997) Anesth Analg , vol.85 , pp. 281-285
    • Kaspar, M.1    Ramsay, M.A.E.2    Nguyen, A.T.3
  • 18
    • 0028813733 scopus 로고
    • Early thrombus formation on heparin-bonded pulmonary artery catheters in patients receiving epsilon-aminocaproic acid
    • Dentz M.E., Slaughter T.F., and Mark J.B. Early thrombus formation on heparin-bonded pulmonary artery catheters in patients receiving epsilon-aminocaproic acid. Anesthesiology 82 (1995) 583-586
    • (1995) Anesthesiology , vol.82 , pp. 583-586
    • Dentz, M.E.1    Slaughter, T.F.2    Mark, J.B.3
  • 19
    • 0034841692 scopus 로고    scopus 로고
    • Intracardiac thrombosis formation and pulmonary thromboembolism immediately after graft reperfusion in 7 patients undergoing liver transplantation
    • Gologorsky E., De Wolf A.M., Scott V., et al. Intracardiac thrombosis formation and pulmonary thromboembolism immediately after graft reperfusion in 7 patients undergoing liver transplantation. Liver Transpl 7 (2001) 783-789
    • (2001) Liver Transpl , vol.7 , pp. 783-789
    • Gologorsky, E.1    De Wolf, A.M.2    Scott, V.3
  • 20
    • 0025063231 scopus 로고
    • Aprotinin and reduction of blood loss and transfusion requirements in orthotopic liver transplantation
    • Mallett S.V., Cox D., Burroughs A.K., et al. Aprotinin and reduction of blood loss and transfusion requirements in orthotopic liver transplantation. Lancet 336 (1990) 886-887
    • (1990) Lancet , vol.336 , pp. 886-887
    • Mallett, S.V.1    Cox, D.2    Burroughs, A.K.3
  • 21
    • 0024347315 scopus 로고
    • Effect of aprotinin on intraoperative bleeding and fibrinolysis in liver transplantation
    • Neuhaus P., Bechstein W.O., Lefebre B., et al. Effect of aprotinin on intraoperative bleeding and fibrinolysis in liver transplantation. Lancet 14 (1989) 924-925
    • (1989) Lancet , vol.14 , pp. 924-925
    • Neuhaus, P.1    Bechstein, W.O.2    Lefebre, B.3
  • 22
    • 0034655629 scopus 로고    scopus 로고
    • Aprotinin and transfusion requirements in orthotopic liver transplantation: A multicentre randomized double-blind study
    • Porte R.J., Molenaar I.Q., Begliomini B., et al. Aprotinin and transfusion requirements in orthotopic liver transplantation: A multicentre randomized double-blind study. Lancet 355 (2000) 1303-1309
    • (2000) Lancet , vol.355 , pp. 1303-1309
    • Porte, R.J.1    Molenaar, I.Q.2    Begliomini, B.3
  • 23
    • 0015186698 scopus 로고
    • Anaphylactic shock secondary to initial trasylol administration
    • Bauer J., Futterman S., and Dreiling D.A. Anaphylactic shock secondary to initial trasylol administration. Am J Gastroenterol 56 (1971) 542-545
    • (1971) Am J Gastroenterol , vol.56 , pp. 542-545
    • Bauer, J.1    Futterman, S.2    Dreiling, D.A.3
  • 24
    • 1242329511 scopus 로고    scopus 로고
    • Intravascular thrombosis and thromboembolism during liver transplantation: Antifibrinolytic therapy implicated?
    • Ramsay M., and Randall H. Intravascular thrombosis and thromboembolism during liver transplantation: Antifibrinolytic therapy implicated?. Liver Transpl 10 (2004) 310-314
    • (2004) Liver Transpl , vol.10 , pp. 310-314
    • Ramsay, M.1    Randall, H.2
  • 25
    • 0028272043 scopus 로고
    • A fatal thrombotic complication during liver transplantation after aprotinin administration
    • Baubillier E., Cherqui D., Dominique C., et al. A fatal thrombotic complication during liver transplantation after aprotinin administration. Transplantation 57 (1994) 1664-1666
    • (1994) Transplantation , vol.57 , pp. 1664-1666
    • Baubillier, E.1    Cherqui, D.2    Dominique, C.3
  • 26
    • 0035007311 scopus 로고    scopus 로고
    • Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: Report of two cases
    • Fitzsimons M.G., Peterfreund R.A., and Raines D.E. Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: Report of two cases. Anesth Analg 92 (2001) 1418-1421
    • (2001) Anesth Analg , vol.92 , pp. 1418-1421
    • Fitzsimons, M.G.1    Peterfreund, R.A.2    Raines, D.E.3
  • 27
    • 0036236853 scopus 로고    scopus 로고
    • Aprotinin and thromboembolism in liver transplantation: Is there really a causal effect? Response
    • Molenaar I.Q., Porte R.J., Fitzsimons M.G., et al. Aprotinin and thromboembolism in liver transplantation: Is there really a causal effect? Response. Anesth Analg 94 (2002) 1367-1368
    • (2002) Anesth Analg , vol.94 , pp. 1367-1368
    • Molenaar, I.Q.1    Porte, R.J.2    Fitzsimons, M.G.3
  • 28
    • 0034767540 scopus 로고    scopus 로고
    • Aprotinin in orthotopic liver transplantation: Evidence for a prohemostatic, but not a prothrombotic effect
    • Molenaar I.Q., Legnani C., Groenland T.H.N., et al. Aprotinin in orthotopic liver transplantation: Evidence for a prohemostatic, but not a prothrombotic effect. Liver Transpl 7 (2001) 896-903
    • (2001) Liver Transpl , vol.7 , pp. 896-903
    • Molenaar, I.Q.1    Legnani, C.2    Groenland, T.H.N.3
  • 29
    • 31344467254 scopus 로고    scopus 로고
    • The risk associated with aprotinin in cardiac surgery
    • Mangano D.T., Tudor I.C., Dietzel C., et al. The risk associated with aprotinin in cardiac surgery. N Engl J Med 354 (2006) 353-365
    • (2006) N Engl J Med , vol.354 , pp. 353-365
    • Mangano, D.T.1    Tudor, I.C.2    Dietzel, C.3
  • 30
    • 33644680067 scopus 로고    scopus 로고
    • A propensity score case-control comparison of aprotinin and tranexemic acid in high-transfusion-risk cardiac surgery
    • Karkouti K., Beattie W.S., Dattilo K.M., et al. A propensity score case-control comparison of aprotinin and tranexemic acid in high-transfusion-risk cardiac surgery. Transfusion 46 (2006) 327-338
    • (2006) Transfusion , vol.46 , pp. 327-338
    • Karkouti, K.1    Beattie, W.S.2    Dattilo, K.M.3
  • 32
    • 17744377992 scopus 로고    scopus 로고
    • A review of aprotinin in orthotopic liver transplantation: Can its harmful effects offset its beneficial effects?
    • Lentschener C., Roche K., and Ozier Y. A review of aprotinin in orthotopic liver transplantation: Can its harmful effects offset its beneficial effects?. Anesth Analg 100 (2005) 1248-1255
    • (2005) Anesth Analg , vol.100 , pp. 1248-1255
    • Lentschener, C.1    Roche, K.2    Ozier, Y.3
  • 33
    • 0024793664 scopus 로고
    • Right-heart dysfunction, pulmonary embolism and paradoxical embolization during liver transplantation. A transesophageal two-dimensional echocardiographic study
    • Ellis J.E., Lichtor J.L., Feinstein S.B., et al. Right-heart dysfunction, pulmonary embolism and paradoxical embolization during liver transplantation. A transesophageal two-dimensional echocardiographic study. Anesth Analg 68 (1989) 777-782
    • (1989) Anesth Analg , vol.68 , pp. 777-782
    • Ellis, J.E.1    Lichtor, J.L.2    Feinstein, S.B.3
  • 34
    • 0032907242 scopus 로고    scopus 로고
    • Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery
    • Shore-Lesserson L., Manspeizer H.E., DePerio M., et al. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg 88 (1999) 312-319
    • (1999) Anesth Analg , vol.88 , pp. 312-319
    • Shore-Lesserson, L.1    Manspeizer, H.E.2    DePerio, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.