Lessons From Spinal Midazolam: When Misuse of Messages From Preclinical Models Exposes Patients to Unnecessary Risks

Regional Anesthesia and Pain Medicine

Volumn 31, Issue 6, 2006, Pages 489-491

  Lavand'homme, Patricia ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; CHOLINESTERASE INHIBITOR; CLONIDINE; MIDAZOLAM;

ANALGESIC ACTIVITY; ARACHNOIDITIS; CAUDA EQUINA SYNDROME; CERVICOBRACHIAL NEURALGIA; CLINICAL DECISION MAKING; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG MISUSE; DRUG SAFETY; EDITORIAL; HUMAN; NEUROTOXICITY; POSTOPERATIVE ANALGESIA; PRIORITY JOURNAL; RISK ASSESSMENT; SPINAL ANESTHESIA;

ANALGESICS; ANESTHESIA, CONDUCTION; ANESTHESIA, SPINAL; ANIMALS; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; HUMANS; INJECTIONS, SPINAL; MIDAZOLAM; NERVE BLOCK; PAIN, POSTOPERATIVE; RISK ASSESSMENT;

EID: 33751322989     PISSN: 10987339     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rapm.2006.07.004     Document Type: Editorial

References (17)

1. Boussofara M., Carlès M., Raucoules-Aimè M., Sellam M., and Horn J.-L. Effects of intrathecal midazolam on postoperative analgesia when added to bupivacaine-clonidine mixture. Reg Anesth Pain Med 31 (2006) 501-505
2. Auroy Y., Narchi P., Messiah A., Litt L., Rouvier B., and Samii K. Serious complications related to regional anesthesia: Results of a prospective survey in France. Anesthesiology 87 (1997) 479-486
3. Pollock J.E. Neurotoxicity of intrathecal local anaesthetics and transient neurological symptoms. Best Pract Res Clin Anaesthesiol 17 (2003) 471-484
4. Hodgson P.S., Neal J.M., Pollock J.E., and Spencer S.L. The Neurotoxicity of drugs given intrathecally (spinal). Anesth Analg 88 (1999) 797-809
5. Demirel E., Ugur H.C., Dolgun H., Kahilogullari G., Sargon M.E., Egemen N., and Kecik Y. The neurotoxic effects of intrathecal midazolam and neostigmine in rabbits. Anaesth Intensive Care 34 (2006) 218-223
6. Erdine S., Yucel A., Ozyalcin S., Ozyuvaci E., Talu G.K., Ahiskali B., Apak H., and Savci N. Neurotoxicity of midazolam in the rabbit. Pain 80 (1999) 419-423
7. Yaksh T.L., and Allen J.W. The use of intrathecal midazolam in humans: A case study of process. Anesth Analg 98 (2004) 1536-1545
8. Yaksh T.L., and Allen J.W. Preclinical insights into the implementation of intrathecal midazolam: A cautionary tale. Anesth Analg 98 (2004) 1509-1511
9. Eisenach J.C. Clinical implementation of agents for spinal delivery. In: Yaksh T.L. (Ed). Spinal Drugs Delivery (1999), Elsevier Science BV, Philadelphia 439-456
10. Johansen M.J., Gradert T.L., Satterfield W.C., Baze W.B., Hildebrand K., Trissel L., and Hassenbusch S.J. Safety of continuous intrathecal midazolam infusion in the sheep model. Anesth Analg 98 (2004) 1528-1535
11. Ugur B., Basaloglu K., Yurtseven T., Ates U., Aydin O.N., Ozenc D., Yurtseven M., and Gurel A. Neurotoxicity with single dose intrathecal midazolam administration. Eur J Anaesthesiol 22 (2005) 907-912
12. Tucker A.P., Lai C., Nadeson R., and Goodchild C.S. Intrathecal midazolam I: A cohort study investigating safety. Anesth Analg 98 (2004) 1512-1520
13. Perren F., Buchser E., Chedel D., Hirt L., Maeder P., and Vingerhoets F. Spinal cord lesion after long-term intrathecal clonidine and bupivacaine treatment for the management of intractable pain. Pain 109 (2004) 189-194
14. Brennan T.J. Frontiers in translational research: The etiology of incisional and postoperative pain. Anesthesiology 97 (2002) 535-537
15. Rane K., Sollevi A., and Segerdahl M. Intrathecal adenosine administration in abdominal hysterectomy lacks analgesic effect. Acta Anaesthesiol Scand 44 (2000) 868-872
16. Kathirvel S., Sadhasivam S., Saxena A., Kannan T.R., and Ganjoo P. Effects of intrathecal ketamine added to bupivacaine for spinal anaesthesia. Anaesthesia 55 (2000) 899-904
17. Walker S.M., Goudas L.C., Cousins M.J., and Carr D.B. Combination spinal analgesic chemotherapy: A systematic review. Anesth Analg 95 (2002) 674-715