Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG

American Journal of Surgical Pathology

Volumn 30, Issue 12, 2006, Pages 1613-1618

  Santagata, Sandro ^a,b   Hornick, Jason L ^a,b   Ligon, Keith L ^a,b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Brain; Germ cell; Germinoma; NANOG; OCT3 4 (POU5F1); SOX2; Stem cell

Indexed keywords

HOMEODOMAIN PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; COMPARATIVE STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; EMBRYONIC STEM CELL; FEMALE; GERM CELL TUMOR; GLIOMA; HISTIOCYTOSIS; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; LYMPHOMA; MALE; MEDULLOBLASTOMA; NEUROECTODERM TUMOR; PROTEIN EXPRESSION; RHABDOID TUMOR; TERATOMA;

ADOLESCENT; ADULT; ALKALINE PHOSPHATASE; BRAIN NEOPLASMS; CELL NUCLEUS; CHILD; DNA-BINDING PROTEINS; GERMINOMA; HMGB PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; ISOENZYMES; OCTAMER TRANSCRIPTION FACTOR-3; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 33751316222     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000213320.04919.1a     Document Type: Article

References (26)

1. Almstrup K, Hoei-Hansen CE, Wirkner U, et al. Embryonic stem cell-like features of testicular carcinoma in situ revealed by genomewide gene expression profiling. Cancer Res. 2004;64:4736-4743.
2. Atkin NB, Baker MC. Specific chromosome change, i(12p), in testicular tumours? Lancet. 1982;2:1349.
3. Boiani M, Scholer HR. Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol. 2005;6:872-884.
4. Boyer LA, Lee TI, Cole MF, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122:947-956.
5. Chambers I. The molecular basis of pluripotency in mouse embryonic stem cells. Cloning Stem Cells. 2004;6:386-391
6. Chambers I, Colby D, Robertson M, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 2003;113:643-655.
7. Cheng L, Thomas A, Roth LM, et al. OCT4: a novel biomarker for dysgerminoma of the ovary. Am J Surg Pathol. 2004;28:1341-1346.
8. Ezeh UI, Turek PJ, Reijo RA, et al. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer. 2005;104:2255-2265.
9. Hart AH, Hartley L, Parker K, et al. The pluripotency homeobox gene NANOG is expressed in human germ cell tumors. Cancer. 2005;104:2092-2098.
10. Hattab EM, Tu PH, Wilson JD, et al. OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. Am J Surg Pathol. 2005;29:368-371.
11. Hay DC, Sutherland L, Clark J, et al. Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells. Stem Cells. 2004;22:225-235.
12. Hoei-Hansen CE, Almstrup K, Nielsen JE, et al. Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. Histopathology. 2005;47:48-56.
13. Ironside JW, Moss TH, Louis DN, et al. Diagnostic Pathology of Nervous System Tumours. Edinburgh, Scotland: Churchill Livingstone; 2001:271-290.
14. Jones TD, Ulbright TM, Eble JN, et al. OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. Am J Surg Pathol. 2004;28:935-940.
15. Korkola JE, Houldsworth J, Chadalavada RS, et al. Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. Cancer Res. 2006;66:820-827.
16. Mitsui K, Tokuzawa Y, Itoh H, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003;113:631-642.
17. Nichols J, Zevnik B, Anastassiadis K, et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 1998;95:379-391.
18. Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet. 2000;24:372-376.
19. Burger PC, Scheithauer BW, Stephen VF. Surgical Pathology of the Nervous System and Its Coverings. Philadelphia, PA: Churchill Livingstone; 2002:325-329.
20. Ralston A, Rossant J. Genetic regulation of stem cell origins in the mouse embryo. Clin Genet. 2005;68:106-112.
21. Reuter VE. Origins and molecular biology of testicular germ cell tumors. Mod Pathol. 2005;18:S51-S60.
22. Rickert CH, Simon R, Bergmann M, et al. Comparative genomic hybridization in pineal germ cell tumors. J Neuropathol Exp Neurol. 2000;59:815-821.
23. Rosenblum MK, Matsutani M, Van Meir EG. CNS Germ Cell Tumors. In: Kleihues P, Cavenee WK, eds. Pathology and Genetics of Tumors of the Nervous System. Lyon, France: IARC Press; 2000:208-214.
24. Shinoda J, Miwa Y, Sakai N, et al. Immunohistochemical study of placental alkaline phosphatase in primary intracranial germ-cell tumors. J Neurosurg. 1985;63:733-739.
25. Sperger JM, Chen X, Draper JS, et al. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A. 2003;100:13350-13355.
26. Zaehres H, Lensch MW, Daheron L, et al. High-efficiency RNA interference in human embryonic stem cells. Stem Cells. 2005;23:299-305.