Hypercalcaemia in relapsed medulloblastoma 8 years post-diagnosis; evidence to support PTHrP production by medulloblastoma cells

Hormone Research

Volumn 66, Issue 6, 2006, Pages 268-272

  Dharmaraj, P ^a   Ball, S ^a   Johnstone, H ^a   Bailey, S ^a   Clifford, S C ^b   Hale, J ^a   Cheetham, T D ^a  

^a ROYAL VICTORIA INFIRMARY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Bony metastases, late relapse; Hypercalcaemia; Medulloblastoma; Parathyroid hormone related protein

Indexed keywords

CALCIUM ION; PARATHYROID HORMONE RELATED PROTEIN;

ADULT; ARTICLE; BONE MARROW METASTASIS; BONE METASTASIS; CALCIUM BLOOD LEVEL; CANCER CELL CULTURE; CANCER INFILTRATION; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CASE REPORT; HISTOPATHOLOGY; HUMAN; HYPERCALCEMIA; IMMUNORADIOMETRIC ASSAY; MALE; MEDULLOBLASTOMA; PATHOGENESIS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; BONE NEOPLASMS; CEREBELLAR NEOPLASMS; CHILD; HUMANS; HYPERCALCEMIA; MALE; MEDULLOBLASTOMA; PARATHYROID HORMONE-RELATED PROTEIN; RECURRENCE;

EID: 33751295602     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095545     Document Type: Article

References (37)

1. Coggeshall J, Merrill W, Hande K, Des Prez R: Implications of hypercalcemia with respect to diagnosis and treatment of lung cancer. Am J Med 1986;80:325.
2. Vassilopoulou-Sellin R, Newman BM, Taylor SH, Guinee VF: Incidence of hypercalcemia in patients with malignancy referred to a comprehensive cancer center [see comment]. Cancer 1993;70:1309.
3. Ratcliffe WA, Hutchesson AC, Bundred NJ, Ratcliffe JG: Role of assays for parathyroid-hormone-related protein in investigation of hypercalcaemia [see comment]. Lancet 1992;339:164.
4. Nussbaum SR, Gaz RD, Arnold A: Hypercalcemia and ectopic secretion of parathyroid hormone by an ovarian carcinoma with rearrangement of the gene for parathyroid hormone. N Engl J Med 1990;323:1324.
5. Ikeda K, Ohno H, Hane M, Yokoi H, Okada M, Honma T, Yamada A, Tatsumi Y, Tanaka T, Saitoh T: Development of a sensitive twosite immunoradiometric assay for parathyroid hormone-related peptide: evidence for elevated levels in plasma from patients with adult T-cell leukemia/lymphoma and B-cell lymphoma. J Clin Endocrinol Metab 1994;79:1322.
6. Ellison DW, Clifford SC, Gajjar A, Gilbertson RJ: What's new in neuro-oncology? Recent advances in medulloblastoma [Review] [64 refs]. Eur J Paediatr Neurol 2003;7:53.
7. Jenkin D: Posterior fossa tumors in childhood: radiation treatment. Clin Neurosurg 1983;30:203.
8. Lindsey J, Lusher M, Anderton J, Bailey S, Gilbertson RJ, Pearson A, Ellison DW, Clifford SC: Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. Carcinogenesis 2004;25:661.
9. Fraser WD, Robinson J, Lawton R, Durham B, Gallacher SJ, Boyle IT, Beastall GH, Logue FC: Clinical and laboratory studies of a new immunoradiometric assay of parathyroid hormone-related protein. Clin Chem 1993;39:414.
10. Mundy GR, Martin TJ: The hypercalcemia of malignancy: pathogenesis and management [Review] [207 refs]. Metabolism 1982;30:1247.
11. Arisaka O, Obinata K, Yabuta K, Ishimoto K, Sato K: Hypercalcaemia in cerebellar medulloblastoma: pathogenesis of solid tumour-associated hypercalcaemia. Eur J Pediatr 1987;146:434.
12. Akyuz C, Yalcin B, Kutluk T, Cila A, Buyukpamukcu M: Medulloblastoma with widespread skeletal metastases presenting with hypercalcemia. Med Pediatr Oncol 1999;33:126.
13. Martin TJ, Atkins D: Biochemical regulators of bone resorption and their significance in cancer. Essays Med Biochem 1979;4:49.
14. Albright F: Case records of the Massachusetts General Hospital (case 27401). N Engl J Med 1940;225:789.
15. Simpson EL, Mundy GR, D'Souza SM, Ibbotson KJ, Bockman R, Jacobs JW: Absence of parathyroid hormone messenger RNA in nonparathyroid tumors associated with hypercalcemia. N Engl J Med 1983;309:325.
16. Strewler GJ, Budayr AA, Clark OH, Nissenson RA: Production of parathyroid hormone by a malignant nonparathyroid tumor in a hypercalcemic patient. J Clin Endocrinol Metab 1993;76:1373.
17. Kukreja SC, Shemerdiak WP, Lad TE, Johnson PA: Elevated nephrogenous cyclic AMP with normal serum parathyroid hormone levels in patients with lung cancer. J Clin Endocrinol Metab 1980;50:167.
18. Stewart AF, Horst R, Deftos LJ, Cadman EC, Lang R, Broadus AE: Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups. N Engl J Med 1980;303:1377.
19. Stewart AF, Mangin M, Wu T, Goumas D, Insogna KL, Burtis WJ, Broadus AE: Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats. J Clin Invest1988;80:596.
20. Suva LJ, Winslow GA, Wettenhall RE, Hammonds RG, Moseley JM, Diefenbach-Jagger H, Rodda CP, Kemp BE, Rodriguez H, Chen EY: A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science 1987;237:893.
21. Martin TJ, Suva LJ: Parathyroid hormonerelated protein in hypercalcaemia of malignancy [Review] [80 refs]. Clin Endocrinol 1989;30:631.
22. Mangin M, Webb AC, Dreyer BE, Posillico JT, Ikeda K, Weir EC, Stewart AF, Bander NH, Milstone L, Barton DE: Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proc Natl Acad Sci USA 1988;85:597.
23. Shigeno C, Yamamoto I, Kitamura N, Noda T, Lee K, Sone T, Shiomi K, Ohtaka A, Fujii N, Yajima, H: Interaction of human parathyroid hormone-related peptide with parathyroid hormone receptors in clonal rat osteosarcoma cells. J Biol Chem 1988;263:18369.
24. Yates AJ, Gutierrez GE, Smolens P, Travis PS, Katz MS, Aufdemorte TB, Boyce BF, Hymer TK, Poser JW, Mundy GR: Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents. J Clin Invest 1988;80:932.
25. Orloff JJ, Wu TL, Stewart AF: Parathyroid hormone-like proteins: biochemical responses and receptor interactions [Review] [136 refs]. Endocr Rev 1989;10:476.
26. Weir EC, Brines ML, Ikeda K, Burtis WJ, Broadus AE, Robbins RJ: Parathyroid hormone-related peptide gene is expressed in the mammalian central nervous system. Proc Natl Acad Sci USA 1990;87:108.
27. Yamamoto M, Harm SC, Grasser WA, Thiede MA: Parathyroid hormone-related protein in the rat urinary bladder: a smooth muscle relaxant produced locally in response to mechanical stretch. Proc Natl Acad Sci USA 1992;89:5326.
28. Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ: Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein [see comment]. Science 1996;273:613.
29. Stewart AF: Clinical practice. Hypercalcemia associated with cancer [Review] [46 refs]. N Engl J Med 2005;352:373.
30. Nakayama K, Fukumoto S, Takeda S, Takeuchi Y, Ishikawa T, Miura M, Hata K, Hane M, Tamura Y, Tanaka Y, Kitaoka M, Obara T, Ogata E, Matsumoto T: Differences in bone and vitamin D metabolism between primary hyperparathyroidism and malignancy-associated hypercalcemia. J Clin Endocrinol Metab 1996;80:607.
31. Horwitz MJ, Tedesco MB, Sereika SM, Hollis BW, Garcia-Ocana A, Stewart AF: Direct comparison of sustained infusion of human parathyroid hormone-related protein-(1-36) [hPTHrP-(1-36)] versus hPTH-(1-34) on serum calcium, plasma 1,25-dihydroxyvitamin D concentrations, and fractional calcium excretion in healthy human volunteers. J Clin Endocrinol Metab 2003;88:1603.
32. Rankin W, Grill V, Martin TJ: Parathyroid hormone-related protein and hypercalcemia [Review] [75 refs]. Cancer 1997;80:1564.
33. Bucht E, Rong H, Pernow Y, Nordqvist AC, Eriksson E, Rankin W, von Schoultz E, Burtis WJ, Granberg B, Falkmer UG, Burton DW, Deftos LJ: Parathyroid hormone-related protein in patients with primary breast cancer and eucalcemia. Cancer Res 1998;58:4113.
34. Motokura T, Fukumoto S, Matsumoto T, Takahashi S, Fujita A, Yamashita T, Igarashi T, Ogata E: Parathyroid hormone-related protein in adult T-cell leukemia-lymphoma. Ann Intern Med 1989;110:484.
35. Isales C, Carcangiu ML, Stewart AF: Hypercalcemia in breast cancer. Reassessment of the mechanism. Am J Med 1987;82:1143.
36. Seymour JF, Gagel RF, Hagemeister FB, Dimopoulos MA, Cabanillas F: Calcitriol production in hypercalcemic and normocalcemic patients with non-Hodgkin lymphoma [see comment]. Ann Intern Med 1994;120:633.
37. Taylor RE, Bailey CC, Robinson K, Weston CL, Ellison D, Ironside J, Lucraft H, Gilbertson R, Tait DM, Walker DA, Pizer BL, Imeson J, Lashford LS: Results of a randomized study of preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma: The International Society of Paediatric Oncology/United Kingdom Children's Cancer Study Group PNET-3 Study. J Clin Oncol 2003;20:1581.