Preoperative chemoradiotherapy with concomitant small field boost irradiation for locally advanced rectal cancer: A multi-institutional phase II study (KROG 04-01)

Diseases of the Colon and Rectum

Volumn 49, Issue 11, 2006, Pages 1684-1691

  Kim, Dae Yong ^a   Kim, Tae Hyun ^a   Jung, Kyung Hae ^a   Chang, Hee Jin ^a   Lim, Seok Byung ^a   Choi, Hyo Seong ^a   Jeong, Seung Yong ^a   Nam, Taek Keun ^b   Ryu, Seong Yeob ^b   Lee, Doo Suk ^c   Choi, Sung Il ^c   Kang, Jin Hyung ^d   Yoon, Sei Chul ^d  

^a National Cancer Center   (South Korea)

^b Chonnam National University Medical School   (South Korea)

^c Daehang Hospital   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

Concomitant boost; Preoperative chemoradiotherapy; Rectal cancer

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ADULT; AGED; ARTICLE; BOLUS INJECTION; CANCER COMBINATION CHEMOTHERAPY; CANCER GRADING; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CLINICAL ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; MALE; MULTIMODALITY CANCER THERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; PREOPERATIVE RADIOTHERAPY; PREOPERATIVE TREATMENT; RADIATION DOSE; RECTUM CANCER; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR REGRESSION; TUMOR VOLUME;

ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; DOSE FRACTIONATION; FEMALE; FLUOROURACIL; HUMANS; INJECTIONS, INTRAVENOUS; LEUCOVORIN; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; PROSPECTIVE STUDIES; RADIOTHERAPY, CONFORMAL; RECTAL NEOPLASMS; VITAMIN B COMPLEX;

EID: 33751294551     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/s10350-006-0678-z     Document Type: Article

References (27)

1. R Sauer H Becker W Hohenberger 2004 Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 1731 1740
2. JP Gerard O Chapet C Nemoz 2004 Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy: The Lyon R96-02 Randomized Trial J Clin Oncol 22 2404 2909
3. A Habr-Gama RO Perez W Nadalin 2005 Long-term results of preoperative chemoradiation for distal rectal cancer correlation between final stage and survival J Gastrointest Surg 9 90 99
4. FM Vecchio V Valentini BD Minsky 2005 The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer Int J Radiat Oncol Biol Phys 62 752 760
5. C Rodel P Martus T Papadoupolos 2005 Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer J Clin Oncol 23 8688 8696
6. AK Chan A Wong D Jenken J Heine D Buie D Johnson 2005 Posttreatment TNM staging is a prognostic indicator of survival and recurrence in tethered or fixed rectal carcinoma after preoperative chemotherapy and radiotherapy Int J Radiat Oncol Biol Phys 61 665 677
7. RD Hofheinz B von Gerstenberg-Helldorf F Wenz 2005 Phase I trial of capecitabine and weekly irinotecan in combination with radiotherapy for neoadjuvant therapy of rectal cancer J Clin Oncol 23 1350 1357
8. VK Mehta C Cho JM Ford 2003 Phase II trial of preoperative 3D conformal radiotherapy, protracted venous infusion 5-fluorouracil, and weekly CPT-11, followed by surgery for ultrasound-staged T3 rectal cancer Int J Radiat Oncol Biol Phys 55 132 137
9. I Chau G Brown D Cunningham 2006 Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer J Clin Oncol 24 668 674
10. V Voelter R Stupp M Matter 2003 Preoperative hyperfractionated accelerated radiotherapy (HART) and concomitant CPT-11 in locally advanced rectal carcinoma: a phase I study Int J Radiat Oncol Biol Phys 56 1288 1294
11. M Mohiuddin K Winter E Mitchell 2006 Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012 J Clin Oncol 24 650 655
12. K Wiltshire J Brierley C Swallow 2004 Preoperative radiation with concurrent chemotherapy for resectable rectal cancer: effect of dose escalation on pathological complete response, local recurrence free survival & disease free survival Int J Radiat Oncol Biol Phys 60(Suppl) 293
13. YH Kim DY Kim TH Kim 2005 Usefulness of magnetic resonance volumetric evaluation in predicting response to preoperative concurrent chemoradiotherapy in patients with resectable rectal cancer Int J Radiat Oncol Biol Phys 62 761 768
14. LH Sobin CH Wittenkind 2002 International Union Against Cancer. TNM classification of malignant tumors 6 Wiley-Liss New York
15. O Dworak L Keilholz A Hoffmann 1997 Pathological features of rectal cancer after preoperative radiochemotherapy Int J Colorectal Dis 12 19 23
16. SB Lim SC Heo MR Lee 2005 Changes in outcome with sphincter preserving surgery for rectal cancer in Korea, 1991-2000 Eur J Surg Oncol 31 242 249
17. P Therasse SG Arbuck EA Eisenhauer 2000 New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst 92 205 216
18. J Widder F Herbst W Dobrowsky 2005 Preoperative short-term radiation therapy (25 Gy, 2.5 Gy twice daily) for primary resectable rectal cancer (phase II) Br J Cancer 92 1209 1214
19. MJ O'Connell JA Martenson HS Wieand 1994 Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery N Engl J Med 331 502 507
20. SR Smalley J Benedetti S Williamson 2004 Intergroup 0144 a phase III rectal surgical adjuvant study of pelvic radiation (XRT) plus 5-FU based chemotherapy (bolus 5-FU before and after PVI + XRT vs. PVI before, during, and after XRT vs. biochemically modulated bolus 5-FU and XRT): mature outcome results and pelvic failure analysis Int J Radiat Oncol Biol Phys 60 Suppl 1 137 138
21. DY Kim KH Jung TH Kim 2006 Does capecitabine improve tumor response more effectively than 5-fluorouracil/leucovorin in preoperative chemoradiotherapy for locally advanced rectal cancer? Comparative analysis of two prospective phase II trials J Korean Soc Coloproctol 22 Suppl 1 102
22. DW Kim DY Kim TH Kim 2006 Is T classification still correlated with lymph node status after preoperative chemoradiotherapy for rectal cancer? Cancer 106 1694 1700
23. JC Kim TW Kim JH Kim 2005 Preoperative concurrent radiotherapy with capecitabine before total mesorectal excision in locally advanced rectal cancer Int J Radiat Oncol Biol Phys 63 346 353
24. JF Bosset G Calais L Mineur 2005 Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results-EORTC 22921 J Clin Oncol 23 5620 5627
25. Losi L, Luppi G, Gavioli M, et al. Prognostic value of Dworak grade of regression (GR) in patients with rectal carcinoma treated with preoperative radiochemotherapy. Int J Colorectal Dis 2005;1-7.
26. HD Thames Jr LJ Peters HR Withers 1983 Accelerated fractionation vs. hyperfractionation: rationales for several treatments per day Int J Radiat Oncol Biol Phys 9 127 138
27. HR Withers 1985 Biologic basis for altered fractionation schemes Cancer 55 2086 2095