The effect of tetrandrine on the expression of the P170, LRP and TOPO II in S180's tumor cell induced by chemotherapy in the mice with acquired multi-drug resistance

Zhongguo Zhongyao Zazhi

Volumn 30, Issue 16, 2005, Pages 1280-1282

  Li, Gui Hai ^a   Liu, Ming Xia ^b   Sun, Fu Jun ^a   Wang, Ning ^c   Yin, Ge Ping ^d   Li, Xiao Jing ^a   Li, Wei Feng ^b  

^a Shandong Academy of Chinese Medicine   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^c Shandong Seminary of Sanitation   (China)

^d JINAN MILITARY GENERAL HOSPITAL   (China)

Author keywords

LRP; Mouse; Multi drug resistance; P170; Tetrandrine; TOPO II; Tumor

Indexed keywords

ALKALOID; BENZYLISOQUINOLINE DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); GLYCOPROTEIN P; HERBACEOUS AGENT; LUNG RESISTANCE PROTEIN; RIBONUCLEOPROTEIN; TETRANDRINE;

ANIMAL; ARTICLE; DRUG RESISTANCE; ENZYMOLOGY; GENE; GENE EXPRESSION REGULATION; METABOLISM; MOUSE; MULTIDRUG RESISTANCE; PATHOLOGY; RANDOMIZATION; SARCOMA 180;

ALKALOIDS; ANIMALS; BENZYLISOQUINOLINES; DNA TOPOISOMERASES, TYPE II; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MDR; MICE; P-GLYCOPROTEIN; RANDOM ALLOCATION; SARCOMA 180; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 33751281256     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. HE Q Y, MENG F H, ZHANG H Q. Reduction of dox or ubicire sistance by tetrandrine and duaricinenarring to nine resistant human leukemia(HL60)cells. Acta Pharma cologicasinica, 1996, 17(2): 17.
2. Choi S U, Park S H, Kim K H, et al. The bisben zylis oquino lineal kaloids, tetrandine and fangchinoline, enhance the cytotoxicity of multidrug resistance relateddrugs viamodulation of P-glycoprotein. Anticancer Drugs, 1998, 9(3): 255.
3. Hamada H, Tsuruo T. Purification of the 170-to 180-kilodalton me mdrane glycoprotein associated with multidrug resistance. 170-to 180-kilodalton membrane glycoprotein is an ATPase. J Bion Chem, 1988, 263(3):1454.
4. List A F. Non-p-glycoprotein drug export mechanisms of multidrug resistance. Semin Hematol, 1997, 34(4): 20.
5. Stride B D, Valdimarsson G, Gerlach J H, et al. Structure and expression of the mRNA encoding the multidrug resistance protein (MRP), an ATP-binding cassette transporter. Mol Pharmacol, 1996, 49(6):962.
6. Rebbeor J F, Connoly G C, Henson JH, et al. ATP-dependent GSH and glutathione S-conjugate transport in skate liver: role of an MRP functional homologue. Am J Physiol Gastrointest Liver Physiol, 2000, 279(2): 417.