Quantitative structure-activity relationship and prediction of mixture toxicity of alkanols

Chinese Science Bulletin

Volumn 51, Issue 22, 2006, Pages 2717-2723

  Wang, Bin ^a   Yu, Gang ^a   Zhang, Zulin ^a   Hu, Hongying ^a   Wang, Liansheng ^b  

^a TSINGHUA UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Alkanol; Equivalent octanol water partition coefficient; Mixture toxicity; Photobacterium phosphoreum; QSAR

Indexed keywords

PHOTOBACTERIUM PHOSPHOREUM;

EID: 33751259824     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-006-2168-z     Document Type: Article

References (22)

1. Backhaus T, Scholze M, Grimme L H. The single substance and mixture toxicity of quinolones to the bioluminescent bacterium Vibrio fischeri. Aquat Toxicol, 2000, 49: 49-61
2. Altenburger R, Backhaus T, Boedeker W. Predictability of the toxicity of multiple chemical mixtures to Vibrio fischeri: mixtures composed of similarly acting Chemicals. Environ Toxicol Chem, 2000, 19: 2341-2347
3. Faust M, Altenburger R, Backhaus T. Predicting the joint algal toxicity of multi-component s-triazine mixtures at low-effect concentrations of individual toxicants. Aquat Toxicol, 2001, 21: 13-32
4. Nirmalakhandan N, Arulgendran V, Mohsin M, et al. Toxicity of mixture of organic chemicals to microorganisms. Water Res, 1994, 28: 543-551
5. Nirmalakhandan N, Xu S, Trevizo C, et al. Additivity in microbial toxicity of nonuniform mixtures of organic chemicals. Ecotoxicol Environ Saf, 1997, 37: 97-102
6. Xu S, Nirmalakhandan N. Use of QSAR models in predicting joint effects in multi-componet mixtures of organic chemicals. Water Res, 1998, 32: 2391-2399
7. Huang H, Wang X D, Shao Y, et al. QSAR for prediction of joint toxicity of substituted phenols to tadpoles (Rana japonica). Bull Environ Contam Toxicol, 2003, 71: 1124-1130
8. Lin Z F, Yu H X, Wei D B, et al. Prediction of mixture toxicity with its total hydrophobicity. Chemosphere, 2002, 46: 305-310
9. Lin Z F, Shi P, Gao S X, et al. Use of partition coefficients to predict mixture toxicity. Water Res, 2003, 37: 2223-2227
10. Lin Z F, Zhong P, Yin K D, et al. Quantification of joint effect for hydrogen bond and development of QSARs for predicting mixture toxicity. Chemosphere, 2003, 52: 1199-1208
11. Lin Z F, Zhong P, Niu X J, et al. A simple hydrophobicity-based approach to predict the toxicity of unknown organic micropollutant mixtures in marine water. Mar Pollu Bull, 2005, 50: 617-623
12. Hatipoǧlu A, Çinar Z. A QSAR study on the kinetics of the reactions of aliphatic alcohols with the photogenerated hydroxyl radicals. J Mol Struc (Theochem), 2003, 631: 189-207
13. Schultz T W, Arnold L M, Teresa S W, et al. Relationships of quantitative-activity for normal aliphatic alcohols. Ecotoxicol Environ Saf, 1990, 19: 243-253
14. Gustavson K E, Svebson A, Harkin J M. Comparison of toxicities and mechanism of action of n-alkanols in the submitochondrial particle and the Vibrio fischeri bioluminescence (Microtox®) bio-assay. Environ Toxicol Chem, 1998, 17: 1917-1921
15. Hammond D G, Kubo I. Structure-activity relationship of alkanols as mosquito larvicides with novel findings regarding their mode of action. Bioorg Med Chem, 1999, 7: 271-278
16. Kabelitz N, Santos P M, Heipieper H J. Effect of aliphatic alcohols on growth and degree of saturation of membrane lipids in Acinetobacter calcoaceticus. FEMS Microbiol Lett, 2003, 220: 223-227
17. Teaching and Research Group of Environmental Biology in Nanjing University. Experimental Techniques and Methods of Environmental Biology (in Chinese). Nanjing: Nanjing University Press, 1989. 145
18. Altenburger R, Nendza M, Schüürmann G. Mixture toxicity and its modeling by quantitative structure-activity relationship. Environ Toxicol Chem, 2000, 19: 2341-2347
19. Donato M M, Jurado A S, Autunes-Madeira V M C. Membrane lipid composition of bacillus stearothermophilus as affected by lipophilic environmental pollutants: an approach to membrane toxicity assessment. Arch Environ Contam Toxicol, 2000, 39: 145-153
20. Franks N B, Lieb W R. Mechanisms of general anesthesia. Environ Health Perspect, 1990, 87: 219-226
21. Connell D W, Hawker D W. Use of polynomial expressions to describe the bioconcentration of hydrophobic chemicals in fish. Ecotoxicol Environ Saf, 1988, 16: 242-257
22. Carlsen L, Walker J D. QSARs for prioritizing PBT substances to promote pollution prevention. QSAR Comb Sci, 2003, 22: 49-57