Enhancement of MALDI-MS spectra of C-terminal peptides by the modification of proteins via an active ester generated in situ from an oxazolone

Analytical Chemistry

Volumn 78, Issue 22, 2006, Pages 7861-7869

  Yamaguchi, Minoru ^a   Oka, Mutsumi ^b   Nishida, Kimiko ^b   Ishida, Mayu ^b   Hamazaki, Ayako ^b   Kuyama, Hiroki ^c   Ando, Eiji ^a   Okamura, Taka Aki ^c   Ueyama, Norikazu ^c   Norioka, Shigemi ^c   Nishimura, Osamu ^a,c   Tsunasawa, Susumu ^a   Nakazawa, Takashi ^b  

^a SHIMADZU CORPORATION   (Japan)

^b NARA WOMEN'S UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; DESORPTION; ESTERS; HYDRAZINE; IONIZATION; MASS SPECTROMETRY; PROTEINS; SPECTRUM ANALYSIS;

C-TERMINAL SEQUENCING; CARBOXYL GROUPS; FORMYLATION; MATRIX ASSISTED LASER DESORPTION/IONIZATION (MALDI);

AMINO ACIDS;

2 HYDRAZINO 2 IMIDAZOLINE; ACETIC ANHYDRIDE; ARGININE METHYL ESTER; ASPARTIC ACID; FORMIC ACID; GLUTAMIC ACID; HYDROXIDE; OXAZOLONE; PENTAFLUOROPHENOL; PEPTIDE; PHENOL; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL MODIFICATION; DRUG MIXTURE; ENZYME ACTIVE SITE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PROTEIN MODIFICATION; REACTION ANALYSIS;

ACETIC ANHYDRIDES; AMIDES; AMINO ACID SEQUENCE; ARGININE; ASPARTIC ACID; ESTERS; FLUOROBENZENES; FORMIC ACIDS; GLUTAMIC ACID; GUANIDINE; HYDRAZINES; IMIDAZOLES; MOLECULAR SEQUENCE DATA; OXAZOLONE; PEPTIDES; PHENOLS; PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 33751238211     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac0610816     Document Type: Article

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