Effects of multidrug resistance, antisense RNA on the chemosensitivity of hepatocellular carcinoma cells

Hepatobiliary and Pancreatic Diseases International

Volumn 5, Issue 4, 2006, Pages 552-559

  Li, Bo ^a   Ye, Tian ^b   Zhao, Lei ^a   Li, De Hua ^c   Gou, Xing Hua ^c   Zhao, Lan Ying ^c   Han, Lei ^c   Chen, Lin ^d   Yan, Lu Nan ^d   Gong, Jian Ping ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b SOUTHWEST MEDICAL UNIVERSITY   (China)

^c Chengdu Di'Ao Pharmaceutical Company   (China)

^d SICHUAN UNIVERSITY   (China)

Author keywords

Antisense nucleic acid; Multiple drug resistance; P glycoprotein

Indexed keywords

COMPLEMENTARY RNA; DAUNORUBICIN; DOXORUBICIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1;

ADENOVIRUS VECTOR; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HEK293; CHEMOSENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SENSITIVITY; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; LIVER CELL CARCINOMA; MULTIDRUG RESISTANCE; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENES, MDR; HUMANS; LIVER NEOPLASMS; P-GLYCOPROTEIN; PLASMIDS; RNA, ANTISENSE; RNA, MESSENGER; TRANSFORMATION, GENETIC;

EID: 33751225632     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Fromm MF. The influence of MDR1 polymorphisms on p-glycoprotein expression and function in humans. Adv Drug Deliv Rev 2002;54:1295-1310.
2. Chang CS, Huang WT, Yang SS, Yeh HZ, Kao CH, Chen GH. Effect of P-glycoprotein and multidrug resistance associated protein gene expression on Tc-99m MIBI imaging in hepatocellular carcinoma. Nucl Med Biol 2003; 30:111-117.
3. Nies AT, Konig J, Pfannschmidt M, Klar E, Hofmann WJ, Keppler D. Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma. Int J Cancer 2001;94:492-499.
4. Michalak K, Hendrich A, Wesolowska O, Pola A. Compounds that modulate multidrug resistance in cancer cells. Cell Biol Mol Lett 2001;6:362-368.
5. Llovet JM, Beaugrand M. Hepatocellular carcinoma: present status and future prospects. J Hepatol 2003;38:S136-S149.
6. Bonin S, Pascolo L, Crocé LS, Stanta G, Tiribelli C. Gene Expression of ABC proteins in hepatocellular carcinoma, perineoplastic tssue, and liver diseases. Mol Med 2002;8: 318-325.
7. Yang JY, Luo HY, Lin QY, Liu ZM, Yan LN, Lin P, et al. Subcellular daunorubicin distribution and its relation to multidrug resistance phenotype in drug-resistant cell line SMMC-7721/R. World J Gastroenterol 2002;8:644-649.
8. Itsubo M, Ishikawa T, Toda G, Tanaka M. Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product P-glycoprotein in primary liver carcinoma. Cancer 1994;73:298-303.
9. Chenivesse X, Franco D, Brechot C. MDR1 (multidrug resistance) gene expression in human primary liver cancer and cirrhosis. J Hepatol 1993;18:168-172.
10. Grude P, Conti F, Mennecier D, Louvel A, Houssin D, Weill B, et al. MDR1 gene expression in hepatocellular carcinoma and the peritumoral liver of patients with and without cirrhosis. Cancer Lett 2002;186:107-113.
11. Minemura M, Tanimura H, Tabor E. Overexpression of multidrug resistance genes MDR1 and cMOAT in human hepatocellular carcinoma and hepatoblastoma cell lines. Int J Oncol 1999;15:559-563.
12. He TC, Zhou S, da Copsta LT, Yu J, Kinzler KW, Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 1998;95:2509-2514.
13. Li B, Gou XH, Chen L, Li DH, Zhao YH, Han L, et al. Construction of the recombinant adenovirus vector carrying antisense multidrug resistance gene. Hepatobiliary Pancreat Dis Int 2006;5:80-84.
14. Schinkel AH, Jonker JW. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 2003;55:3-29.
15. Higgins CF. ABC transporters: physiology, structure and mechanism: an overview. Res Microbiol 2001;152:205-210.
16. Fine RL, Chambers TC, Sachs CW. P-Glycoprotein, multidrug resistance and protein kinase C. Oncologist 1996; 1:261-268.
17. Chen CJ, Clark D, Ueda K, Pastan I, Gottesman MM, Roninson IB. Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoprotein. J Biol Chem 1990;265:506-514.
18. Zgurskaya HI, Nikaido H. Multidrug resistance mechanisms: drug efflux across two membranes. Mol Microbiol 2000;37:219-225.
19. Thomas H, Coley HM. Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting P-glycoprotein. Cancer Control 2003; 10:159-165.
20. Drobnál Z, Stein U, Walther W, Baranèík M, Breier A. Pentoxifylline influences drug transport activity of p-glycoprotein and decreases mdr1 gene expression in multidrug resistant mouse leukemic L1210/VCR Cells. Gen Physiol Biophys 2002;21:103-109.
21. Sikic BI, Fisher GA, Lum BL, Halsey J, Beketic-Oreskovic L, Chen G. Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein. Cancer Chemother Pharmacol 1997;40 (Suppl):S13-S19.
22. Sczakiel. Theoretical and experimental approaches to design effective antisense oligonucleotides. Front Biosci 2000;5: D194-D201.
23. Motomura S, Motoji T, Takanashi M, Wang YH, Shiozaki H, Sugawara I, et al. Inhibition of P-glycoprotein and recovery of drug sensitivity of human acute leukemic blast cells by multidrug resistance gene (mdr1) antisense oligonucleotides. Blood 1998;91:3163-3171.
24. Pan LG, Tong Y, Jin Y, Zhou S, Zhang Y, Yang XY, et al. Reversing drug resistance in the ovarian carcinoma cell line SKOV3/mdr in vitro by antisense oligodeoxynucleotides. Chin Med J (Engl) 2001;114:929-932.
25. Chan JYW, Chu AC, Fung KP. Inhibition of P-glycoprotein expression and reversal of drug resistance of human hepatoma HepG2 cells by multidrug resistance (mdr1) antisense RNA. Life Sci 2002;67:2117-2124.
26. Borst P. Genetic mechanisms of drug resistance. Acta Oncol 1991;30:87-105.
27. Anderson RD, Haskell R, Xia H, Roessler BJ, Davidson BL. A simple method for the rapid generation of recombinant adenovirus vectors. Gene Ther 2000;7:1034-1038.
28. Ueda K, Pastan I, Gottesman MM. Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene. J Biol Chem 1987;262:17432-17436
29. Devine SE, Hussain A, Davide JP, Meleras PW. Full length and alternatively spliced pgpl transcripts in multidrug-resistant chinese hamster lung cells. J Biol Chem 1991;266: 4545-4555.
30. Noonan KE, Beck C, Holzmayer TA, Chin JE, Wunder JS, Andrulis IL, et al. Quantitative analysis of mdr1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc Natl Acad Sci USA 1990;87:7160-7164.
31. Li Y, Wang YZ. Inhibition Growth of Multidrug Resistant KBV200 Cells by MDR1 Antisense RNA. Biochem Biophys Res Commun 1997;239:345-348.
32. Bodo A, Bakos E, Szeri F, Varadi A, Sarkadi B. The role of multidrug transporters in drug availability, metabolism and toxicity. Toxicol Lett 2003;140-141:133-143.