Cascade of levodopa dose and weight-related dyskinesia in Parkinson's disease (LD-WD-PD cascade)

Parkinsonism and Related Disorders

Volumn 12, Issue 8, 2006, Pages 499-505

  Sharma, Jagdish C ^a   Macnamara, Lorna ^a   Hasoon, Mohammad ^a   Vassallo, Michael ^b   Ross, Ian ^a  

^a SHERWOOD FOREST HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b Mansfield Community Hospital   (United Kingdom)

Author keywords

Body weight; Dyskinesia; Levodopa dose; Parkinson's disease; Weight loss

Indexed keywords

AMANTADINE; APOMORPHINE; AROMATIC LEVO AMINO ACID DECARBOXYLASE; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; SELEGILINE;

ADULT; AGED; ARTICLE; BODY WEIGHT; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE DURATION; DYSKINESIA; FEMALE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; RISK FACTOR; SIDE EFFECT; STATISTICAL SIGNIFICANCE; WEIGHT CHANGE; WEIGHT REDUCTION;

AGED; AGED, 80 AND OVER; ANTIPARKINSON AGENTS; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DYSKINESIA, DRUG-INDUCED; FEMALE; HUMANS; LEVODOPA; LOGISTIC MODELS; MALE; PARKINSON DISEASE; RETROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; WEIGHT LOSS;

EID: 33751212183     PISSN: 13538020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2006.07.002     Document Type: Article

References (15)

1. Ahlskog J.E., and Muenter M.D. Frequency of levodopa related dyskinesia and motor fluctuations as estimated from the cumulative literature. Movement Disord 16 (2001) 448-458
2. Rascol O., Brookes D., Korczyn A.D., De Deyn P.P., Clarke C.E., and Lang A.E. A five year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa. N Engl J Med 342 (2000) 1484-1491
3. CALM-PD Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of Pramipexole vs. levodopa on Parkinson disease progression. JAMA 287 (2002) 1653-1661
4. Whone A.L., Watts R.L., Stoessl A.J., Davis M., Reske S., Nahmias C., et al. Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study. Ann Neurol 54 (2003) 93-101
5. Schrag A., and Quinn N. Dyskinesia and motor fluctuations in Parkinson's disease. A community based study. Brain 123 (2000) 2297-2305
6. Lyons K.E., Hubbie J.P., Troster A.I., Pahwa R., and Koller W.C. Gender differences in Parkinson's disease. Clin Neuropharmacol 21 (1998) 118-121
7. Kostic V., Przedborski S., Flaster E., and Sternic N. Early development of levodopa-induced dyskinesia and response fluctuations in young-onset Parkinson's disease. Neurology 41 (1991) 202-205
8. Olanow C.W., Agid Yves, Mizuno Y., Albanese A., Bonucelli U., Damier P., et al. Levodopa in the treatment of Parkinson's disease: current controversies. Movement Disord 19 (2004) 997-1005
9. Clarke C.E. Does levodopa therapy delay death in Parkinson's disease? A review of the evidence. Movement Disord 10 (1995) 250-256
10. Sharma J.C., and Ross I.N. Long term role of pergolide as an adjunct therapy in Parkinson's disease: influence on disability, blood pressure, weight and levodopa syndrome. Parkinsonism Relat Disord 5 (1999) 111-114
11. Palhagen S., Lorefalt B., Carrison M., Ganowiak W., Toss G., Unosson M., et al. Does l-dopa treatment contribute to reduction in body weight in elderly patients with Parkinson's disease?. Acta Neurol Scand 111 (2005) 12-20
12. Zappia M., Crescibene L., Arabia G., Nicoletti G., Bagala A., Bastone L., et al. Body weight influences pharmacokinetics of levodopa in Parkinson's disease. Clin Neuropharmacol 25 (2002) 79-82
13. Verhagen M.L., Del D.P., van den Munekhof P., Fang J., Mouradian M.M., and Chase T.N. Amantadine as treatment for dyskinesia and motor fluctuations in Parkinson's disease. Neurology 50 (1998) 1323-1326
14. Richardson C., Lees A.J., and turner R. The use of apomorphine in Parkinson's disease. Pharmaceutical J 262 (1999) 264-266
15. Olanow C.W., and Stocchi F. COMT inhibitors in Parkinson's disease: can they prevent and/or reverse levodopa-induced motor complications?. Neurology 13 62, suppl. 1 (2004) S72-S81