Granulosa Cell Tumors of the Equine Ovary

Veterinary Clinics of North America - Equine Practice

Volumn 22, Issue 3, 2006, Pages 799-817

  McCue, Patrick M ^a   Roser, Janet F ^b   Munro, Coralie J ^b   Liu, Irwin K M ^b   Lasley, Bill L ^b  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE;

ANIMAL; ANIMAL DISEASE; BLOOD; DIFFERENTIAL DIAGNOSIS; FEMALE; GRANULOSA CELL TUMOR; HORSE; HORSE DISEASE; OVARY TUMOR; PATHOPHYSIOLOGY; REVIEW;

ANIMALS; DIAGNOSIS, DIFFERENTIAL; FEMALE; GRANULOSA CELL TUMOR; HORMONES; HORSE DISEASES; HORSES; OVARIAN NEOPLASMS;

EQUIDAE;

EID: 33751206830     PISSN: 07490739     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cveq.2006.08.008     Document Type: Review

References (95)

1. Chen V.W., Ruiz B., Killeen J.L., et al. Pathology and classification of ovarian tumors. Cancer 97 (2003) 2631-2642
2. Kennedy P.C., Cullen J.M., Edwards J.F., et al. Histological classification of the tumors of the genital system. In: Schulman F.Y. (Ed). World Health Organization, histological classification of tumors of domestic animals (1998), The Armed Forces Institute of Pathology, Washington (DC) 24-28
3. Panciera R.J., Slusher S.A., and Hayes K.E. Ovarian teratoma and granulosa cell tumor in two mares. Cornell Vet 81 (1991) 43-50
4. Bosu W.T.K., and Smith C.A. Ovarian abnormalities. In: McKinnon A.O., and Voss J.L. (Eds). Equine reproduction (1993), Lea & Febiger, Philadelphia 397-407
5. Clark T.L. Clinical management of equine ovarian neoplasms. J Reprod Fertil Suppl 23 (1975) 331-334
6. Cordes D.O. Equine granulosa tumours. Vet Rec 85 (1969) 186-188
7. Hughes JP, Kennedy PC, Stabenfeldt GH. Pathology of the ovary and ovarian disorders in the mare. In: Proceedings of the Ninth International Congress on Animal Reproduction and Artificial Insemination. Madrid, Spain; 1980. p. 203-22.
8. Meagher D.M., Wheat J.D., Hughes J.P., et al. Granulosa cell tumors in mares-a review of 78 cases. Proc Am Assoc Equine Pract 23 (1977) 133-143
9. Norris H.J., Taylor H.B., and Garner F.M. Equine ovarian granulosa tumours. Vet Rec 82 (1968) 419-420
10. McCue P.M., Taylor H.B., and Garner F.M. Neoplasia of the female reproductive tract. Vet Clin Equine 14 (1998) 505-515
11. Sundberg J.P., Burnstein T., Page E.H., et al. Neoplasms of equidae. J Am Vet Med Assoc 170 (1977) 150-152
12. Jubb K.V.F., Kennedy P.C., and Palmer N. Pathology of domestic animals, vol. 3. 3rd edition (1985), Academic Press, New York p. 305-23
13. Nielsen S.W., and Kennedy P.C. Tumors of the genital systems. In: Moulton J.E. (Ed). Tumors in domestic animals. 3rd edition (1990), University of California Press, Berkeley (CA) 479-517
14. MacLachlan N.J. Ovarian disorders in domestic animals. Environ Health Perspect 73 (1987) 27-33
15. Green S.L., Specht T.E., Dowling S.C., et al. Hemoperitoneum caused by rupture of a juvenile granulosa cell tumor in an equine neonate. J Am Vet Med Assoc 193 (1988) 1417-1419
16. Buergelt C.D. Ovarian tumors. Color atlas of reproductive pathology of domestic animals (1997), Mosby, St. Louis (MO) 100-111
17. Hultgren B.D., Zack P.M., Pearson E.G., et al. Juvenile granulosa cell tumor in an equine weanling. J Comp Pathol 97 (1987) 137-142
18. Baumann L.E., Sillerud C.L., and Spolar-Kilroy C.R. Equine granulosa cell tumors. A review of fifteen cases. Minn Vet 25 (1985) 52-54
19. Stickle R.L., Erb R.E., Fessler J.F., et al. Equine granulosa cell tumors. J Am Vet Med Assoc 167 (1975) 148-151
20. Bergeron H., Crouch G.M., and Bowen J.M. Granulosa theca cell tumor in a mare. Compend Contin Educ Pract Vet 5 Suppl (1983) S141-S144
21. Schmidt G.R., Cowles R.R., and Flynn D.V. Granulosa cell tumor in a broodmare. J Am Vet Med Assoc 169 (1976) 635
22. McEntee K. Reproductive pathology of domestic animals (1990), Academic Press, New York p. 79-84
23. Gift L.J., Gaughan E.M., and Schoning P. Metastatic granulosa cell tumor in a mare. J Am Vet Med Assoc 200 (1992) 1525-1526
24. Fessler J.F., and Brobst D.F. Granulosa cell tumor. Cornell Vet 62 (1972) 110-123
25. Howard F.A. Granulosa cell tumor of the equine ovary-a case report. J Am Vet Med Assoc 114 (1949) 134-135
26. Perino L.J., and Didier P.J. Equine granulosa cell tumors. Equine Pract 7 (1985) 14-17
27. Stabenfeldt G.H., Hughes J.P., Kennedy P.C., et al. Clinical findings, pathological changes and endocrinological secretory patterns in mares with ovarian tumours. J Reprod Fertil Suppl 27 (1979) 277-285
28. McCoy D.J. Diabetes mellitus associated with bilateral granulosa cell tumors. J Am Vet Med Assoc 188 (1986) 733-735
29. Turner T.A., and Manno M. Bilateral granulosa cell tumor in a mare. J Am Vet Med Assoc 182 (1983) 713-714
30. Hinrichs K., and Hunt P.R. Ultrasound as an aid to diagnosis of granulosa cell tumour in the mare. Equine Vet J 22 (1990) 99-103
31. McCue P.M., LeBlanc M.M., Akita G.Y., et al. Granulosa cell tumors in two cycling mares. J Equine Vet Sci 11 (1991) 281-282
32. Nie G.J., and Momont H. Ovarian mass in three mares with regular estrous cycles. J Am Vet Med Assoc 201 (1992) 1043-1044
33. Swisher H.P. A clinical case of granulosa-cell tumor in a Thoroughbred mare. Southwest Vet 20 (1967) 234-235
34. Finocchio E.J., and Johnson J.H. Granulosa cell tumor in a mare. Veterinary Medicine/Small Animal Clinician 64 (1969) 322-327
35. Nyack B., and Johnson A.D. A mammoth granulosa cell tumor in a mare. Veterinary Medicine/Small Animal Clinician 78 (1983) 218-223
36. Gatewood D.M., Douglass J.P., Cox J.H., et al. Intra-abdominal hemorrhage associated with a granulosa-thecal cell neoplasm in a mare. J Am Vet Med Assoc 196 (1990) 1827-1828
37. Wilson D.A., Foreman J.H., Boero M.J., et al. Small colon rupture attributable to a granulosa cell tumor in a mare. J Am Vet Med Assoc 194 (1989) 681-682
38. Catone G., Marino G., Mancuso R., et al. Clinicopathological features of an equine ovarian teratoma. Reprod Domest Anim 39 (2004) 65-69
39. Fischer A.T., Lloyd K.C., Carlson G.P., et al. Diagnostic laparoscopy in the horse. J Am Vet Med Assoc 189 (1986) 289-292
40. Pugh D.G., Bowen J.M., and Gaughan E.M. Equine ovarian tumors. Compend Contin Educ Pract Vet 7 Suppl (1985) S710-S717
41. Rambags B.P., Stout T.A., and Rijkenhuizen A.B. Ovarian granulosa cell tumours adherent to other abdominal organs; surgical removal from 2 warmblood mares. Equine Vet J 35 (2003) 627-632
42. Baker C.B., and Kenney R.M. Systematic approach to the diagnosis of the infertile or subfertile mare. In: Morrow D.A. (Ed). Current therapy in theriogenology (1980), WB Saunders, Philadelphia 721-736
43. Hinrichs K., Cochran S.L., Schelling S.H., et al. Granulosa-theca cell tumor associated with an ovulation fossa and normal ovarian stroma in a mare. J Am Vet Med Assoc 200 (1992) 696-698
44. White R.A.S., and Allen W.R. Use of ultrasound echography for the differential diagnosis of a granulosa cell tumour in a mare. Equine Vet J 17 (1985) 401-402
45. McCue P.M. Review of ovarian abnormalities in the mare. Proc Am Assoc Equine Pract 45 (1998) 125-133
46. McCue P.M. Pathophysiology of follicular development. [PhD dissertation] (1993), University of California, Davis, Davis (CA) p. 148-75
47. Bailey M.T., Troedsson M.H.T., and Wheaton J.E. Inhibin concentrations in mares with granulosa cell tumors. Theriogenology 57 (2002) 1885-1895
48. Meinecke B., and Gips H. Steroid hormone secretory patterns in mares with granulosa cell tumors. Zentralblatt fur Veterinarmedizen Reihe A 34 (1987) 545-560
49. Kenney R.M., and Ganjam V.K. Selected pathological changes of the mare uterus and ovary. J Reprod Fertil Suppl 23 (1975) 335-339
50. Watson E.D., and Thomson S.R.M. Immunolocalization of aromatase P-450 in ovarian tissue from pregnant and nonpregnant mares and in ovarian tumours. J Reprod Fertil 108 (1996) 239-244
51. Hinrichs K., Watson E.D., and Kenney R.M. Granulosa cell tumor in a mare with a functional contralateral ovary. J Am Vet Med Assoc 197 (1990) 1037-1038
52. Cuevas P., Ying S.Y., Ling N., et al. Immunohistochemical detection of inhibin in the gonad. Biochem Biophys Res Commun 142 (1987) 23-30
53. Phillips D.J. Activins, inhibins and follistatins in the large domestic species. Domest Anim Endocrinol 28 (2005) 1-16
54. B subunits in the ovary. Biol Reprod 59 (1998) 1392-1398
55. de Kretser D.M., and Robertson D.M. The isolation and physiology of inhibin and related proteins. Biol Reprod 40 (1989) 33-47
56. Ginther O.J. Selection of the dominant follicle in cattle and horses. Anim Reprod Sci 60-61 (2000) 61-79
57. Bergfelt D.R., Mann B.G., Schwartz N.B., et al. Circulating concentrations of immunoreactive inhibin and FSH during the estrous cycle of mares. J Equine Vet Sci 11 (1991) 319-322
58. Roser J.F., McCue P.M., and Hoye E. Inhibin activity in the mare and stallion. Domest Anim Endocrinol 11 (1994) 87-100
59. Robertson D.M., Giacometti M., Foulds L.M., et al. Isolation of inhibin α subunit precursor proteins from bovine follicular fluid. Endocrinology 125 (1989) 2141-2149
60. Lappohn R.E., Burger H.G., Bouma J., et al. Inhibin as a marker for granulosa-cell tumors. N Engl J Med 321 (1989) 790-793
61. Grootenhuis A.J., van Sluijs F.J., Klaij I.A., et al. Inhibin, gonadotropins and sex steroids in dogs with Sertoli cell tumours. J Endocrinol 127 (1990) 235-242
62. A-subunit messenger ribonucleic acids and proteins. Biol Reprod 43 (1990) 1050-1057
63. McCue P.M. Equine granulosa cell tumors. Proc Am Assoc Equine Pract 38 (1992) 587-593
64. Christman S.A., Bailey M.T., Wheaton J.E., et al. Dimeric inhibin concentrations in mares with granulosa-theca cell tumors. Am J Vet Res 60 (1999) 1407-1410
65. Watson E.D., Heald M., Leask R., et al. Detection of high circulating concentrations of inhibin pro- and -αC immunoreactivity in mares with granulosa-theca cell tumours. Equine Vet J 34 (2002) 203-206
66. Evans M.J., Loy R.G., Taylor T.B., et al. Administration of steroid-free follicular fluid (FF) to cyclic mares; FSH response to exogenous GnRH. [abstract]. J Anim Sci 53 (1981) 313
67. McCue P.M., Carney N.J., Hughes J.P., et al. Ovulation and embryo recovery rates following immunization of mares against an inhibin alpha-subunit fragment. Theriogenology 38 (1992) 823-831
68. McKinnon A.O., Brown R.W., Pashen R.L., et al. Increased ovulation rates in mares after immunization against recombinant bovine inhibin α-subunit. Equine Vet J 24 (1992) 144-146
69. Thompson D.L., Reville-Moroz S.I., Derrick D.J., et al. Effects of testosterone, dihydrotestosterone and estradiol on gonadotropin release after gonadotropin releasing hormone administration in cyclic mares. Biol Reprod 29 (1983) 970-976
70. Thompson D.L., Garza F., St. George R.L., et al. Relationships among LH, FSH and prolactin secretion, storage and response to secretagogue and hypothalamic GnRH content in ovariectomized pony mares administered testosterone, dihydrotestosterone, estradiol, progesterone, dexamethasone or follicular fluid. Domest Anim Endocrinol 8 (1991) 189-199
71. Lavoie J.P., Carlson G.P., and George L. Hypertrophic osteopathy in three horses and a pony. J Am Vet Med Assoc 201 (1992) 1900-1904
72. Patrick D.J., Kiupel M., Gerber V., et al. Malignant granulosa-theca cell tumor in a two-year-old Miniature Horse. J Vet Diagn Invest 15 (2003) 60-63
73. Van der Zaag E.J., Rijkenhuizen A.B.M., Kalsbeek H.C., et al. A mare with colic caused by an ovarian tumour. Vet Q 18 (1996) 60-62
74. Alexander G.R., Tweedie M.A., Lescun T.B., et al. Haemoperitoneum secondary to granulosa cell tumour in two mares. Aust Vet J 82 (2004) 481-484
75. Sedrish S.A., McClure J.R., Pinto C., et al. Ovarian torsion associated with granulosa-theca cell tumor in a mare. J Am Vet Med Assoc 211 (1997) 1152-1154
76. McLennan M.W., and Kelly W.R. Hypertropic osteopathy and dysgerminoma in a mare. Aust Vet J 53 (1977) 144-146
77. Meuten D.J., and Rendano V. Hypertrophic osteopathy and dysgerminoma in a mare. J Equine Med Surg 2 (1978) 445-450
78. Henson K.L., Alleman A.R., Cutler T.J., et al. Regression of subcutaneous lymphoma following removal of an ovarian granulosa theca cell tumor in a horse. J Am Vet Med Assoc 212 (1998) 1419-1422
79. Hovell G.J.R., and Hignett S.L. Equine ovarian granulosa tumours. Vet Rec 83 (1968) 607
80. Lefebvre R., Theoret C., Dore M., et al. Ovarian teratoma and endometritis in a mare. Can Vet J 46 (2005) 1029-1033
81. Frazer G.S., and Threlfall W.R. Differential diagnosis of enlarged ovary in the mare. Proc Am Assoc Equine Pract 32 (1986) 21-28
82. Held J.-P., Buergelt C., and Colahan P. Serous cystadenoma in a mare. J Am Vet Med Assoc 181 (1982) 496-498
83. Hinrichs K., Frazer G.S., deGannes R.V.G., et al. Serous cystadenoma in a normally cyclic mare with high plasma testosterone values. J Am Vet Med Assoc 194 (1989) 381-382
84. Bridges E.R., Lowder M.Q., Gorham S.L., et al. Serous cystadenoma in a pregnant mare. Equine Pract 16 (1994) 15-17
85. Chandra A.M.S., Woodward J.C., and Merritt A.M. Dysgerminoma in an Arabian filly. Vet Pathol 35 (1998) 308-311
86. Gehlen H, Haist V, Baumgartner W, et al. Malignant dysgerminoma in an 18-year-old Warmblood mare. 2006;26:23-6.
87. Liu I.K.M. Ovarian tumors. In: Robinson N.E. (Ed). Current therapy in equine medicine (1983), WB Saunders, Philadelphia 408-409
88. Lock T.F., and Macy D.W. Equine ovarian lymphosarcoma. J Am Vet Med Assoc 175 (1979) 72-73
89. Van Camp S.D., Mahler J., Roberts M.C., et al. Primary ovarian adenocarcinoma associated with teratomatous elements in a mare. J Am Vet Med Assoc 194 (1989) 1728-1730
90. Ginther O.J. Characteristics of the ovulatory season. Reproductive biology of the mare. Basic and applied aspects. 2nd edition (1992), Equiservices, Cross Plains (WI) 173-232
91. Colbern G.T., and Reagan W.J. Ovariectomy by colpotomy in mares. Compend Contin Educ Pract Vet 9 (1987) 1035-1039
92. Neely D.P. Reproductive endocrinology and fertility in the mare. Equine reproduction (1983), Hoffman-LaRoche, Nutley (NJ) 12-22
93. Embertson R.M. Ovaries and uterus. In: Auer J.A., and Stick J.A. (Eds). Equine surgery (2006), WB Saunders Elsevier, St. Louis (MO) 855-864
94. Palmer S.E. Laparoscopic removal of granulosa cell tumors in the standing horse. In: Fischer A.T. (Ed). Equine diagnostic and surgical laparoscopy (2002), WB Saunders, Philadelphia 205-210
95. Ragle C.A. Ventral abdominal approach for laparoscopic removal of granulosa cell tumors. In: Fischer A.T. (Ed). Equine diagnostic and surgical laparoscopy (2002), WB Saunders, Philadelphia 197-204