Clinical manifestations of hemoglobin Chico at high altitude

Journal of Pediatric Hematology/Oncology

Volumn 28, Issue 11, 2006, Pages 760-762

  Starkey, Cindi R ^a   Davies, Lea ^a   Hoyer, James D ^b   Wilson, Carla S ^a   Winter, Stuart S ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Asthma; Digital clubbing; Hemoglobin Chico; Low affinity hemoglobin

Indexed keywords

ARTICLE; CARDIOPULMONARY EXERCISE TEST; CASE REPORT; CLINICAL FEATURE; DISEASE COURSE; FOLLOW UP; HEMOGLOBIN CHICO; HEMOGLOBINOPATHY; HUMAN; LABORATORY TEST; LUNG FUNCTION TEST; MALE; OXYGEN DISSOCIATION CURVE; PHYSICAL EXAMINATION; PRESCHOOL CHILD; PRIORITY JOURNAL;

ADOLESCENT; ALTITUDE; ANEMIA; ASTHMA; HEMOGLOBINOPATHIES; HEMOGLOBINS, ABNORMAL; HUMANS; MALE; OXIMETRY;

EID: 33751205924     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/01.mph.0000243659.71679.e9     Document Type: Article

References (12)

1. Shih DT, Jones RT, Shih MF, et al. Hemoglobin Chico [beta 66(E10)Lys - Thr]: a new variant with decreased oxygen affinity. Hemoglobin. 1987;11:453-464.
2. Bonaventura C, Bonaventura J, Shih DT, et al. Altered ligand rebinding kinetics due to distal-side effects in hemoglobin chico (Lysbeta66(E10) → thr). J Biol Chem. 1999;274:8686-8693.
3. Rao M, Victoria MS, Maraya R, et al. Digital clubbing in children with chronic asthma - a clinical experience at Kings County Hospital. J Asthma. 1981;18:49-50.
4. Adekile AD. Arterial oxygen tension, haemoglobin F and red cell 2, 3 diphosphoglycerate in sickle cell anaemia patients with digital clubbing. Ann Trop Paediatr. 1989;9:165-168.
5. Sinniah D, White JC, Omar A, et al. Digital clubbing - a clinical sign in thalassemia. J Pediatr. 1978;92:597-599.
6. Huehns ER, Hecht F, Yoshida A, et al. Hemoglobin-Seattle (alpha-2 beta-2 76-Glu): an unstable hemoglobin causing chronic hemolytic anemia. Blood. 1970;36:209-218.
7. Nagel RL, Lynfield J, Johnson J, et al. Hemoglobin Beth Israel. A mutant causing clinically apparent cyanosis. N Engl J Med. 1976;295:125-130.
8. Stamatoyannopoulos G, Parer JT, Finch CA. Physiologic implications of a hemoglobin with decreased oxygen affinity (hemoglobin seattle). N Engl J Med. 1969;281:916-919.
9. Nagai M, Yoneyama Y, Kitagawa T. Unusual CO bonding geometry in abnormal subunits of hemoglobin M Boston and hemoglobin M Saskatoon. Biochemistry. 1991;30:6495-6503.
10. Pik C, Raine DN. The chemical identification of two cases of Hb M (Hb M Boston and Hb M Saskatoon) occurring in England. Clin Chim Acta. 1964;10:90-92.
11. Murray CB, Loughlin GM. Making the most of pulse oximetry. Contemp Pediatr. 1995;12:5-7, 45-52, 61-62.
12. Bruns CM, Thet LA, Woodson RD, et al. Hemoglobinopathy case finding by pulse oximetry. Am J Hematol. 2003;74:142-143.