Has the change to acellular pertussis vaccine improved or worsened pertussis control?

CMAJ. Canadian Medical Association Journal

Volumn 175, Issue 10, 2006, Pages 1227-1228

  Halperin, Scott A ^a,c   De Serres, Gaston ^b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c IWK HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACELLULAR VACCINE; HAEMOPHILUS INFLUENZAE TYPE B VACCINE; PERTUSSIS VACCINE; POLIOMYELITIS VACCINE; TETANUS TOXOID;

CANADA; CLINICAL TRIAL; DISEASE TRANSMISSION; HEALTH CARE PERSONNEL; HEALTH SURVEY; HUMAN; IMMUNITY; INCIDENCE; NOTE; PERTUSSIS; VACCINATION;

EID: 33751204452     PISSN: 08203946     EISSN: 14882329     Source Type: Journal    
DOI: 10.1503/cmaj.060817     Document Type: Note

References (12)

1. Vickers D, Ross AG, Mainar-Jaime RC, et al. Whole-cell and acellular pertussis vaccination programs and rates of pertussis among infants and young children. CMAJ 2006;175(10);1213-7.
2. Halperin SA, Bortolussi R, MacLean D, et al. Persistence of pertussis in an immunized population: results of the Nova Scotia Enhanced Pertussis Surveillance Program. J Pediatr 1989;115:686-93.
3. De Serres G, Boulianne N, Duval B, et al. Effectiveness of a whole cell pertussis vaccine in child-care centers and schools. Pediatr Infect Dis J 1996;15:519-24.
4. Bentsi-Enchill AD, Halperin SA, Scott J, et al. Estimates of the effectiveness of a whole-cell pertussis vaccine from an outbreak in an immunized population. Vaccine 1997;15:301-6.
5. Ntezayabo B, De Serres G, Duval B. Pertussis resurgence in Canada largely caused by a cohort effect. Pediatr Infect Dis J 2003;22:22-7.
6. Skowronski DM, DeSerres G, MacDonald D, et al. The changing age and seasonal profile of pertussis in Canada. J Infect Dis 2002;185:1448-53.
7. Gustafsson L, Hallander HO, Olin P, et al. A controlled trial of a two-component acellular, a five-component acellular, and a whole-cell pertussis vaccine. N Engl J Med 1996;334:349-55.
8. De Serres G, Shadmani R, Boulianne N, et al. Effectiveness of a single dose of acellular pertussis vaccine to prevent pertussis in children primed with pertussis whole cell vaccine. Vaccine 2001;19:3004-8.
9. Galanis E, King AS, Varughese P, et al; IMPACT investigators. Changing epidemiology and emerging risk groups for pertussis. CMAJ 2006;174(4):451-2.
10. Scheifele DW, Halperin SA; CPS/Health Canada Immunization Monitoring Program, Active (IMPACT). Immunization Monitoring Program, Active: a model of active surveillance of vaccine safety. Semin Pediatr Infect Dis 2003;14:213-9.
11. Bettinger JA, Halperin SA, De Serres G, et al; Canadian Immunization Monitoring Program, Active (IMPACT). The effect of changing from whole-cell to acellular pertussis vaccine on the incidence of hospitalized children with pertussis in Canada. Pediatr Infect Dis J. In press.
12. Bettinger JA, Halperin SA, De Serres G, et al; Canadian Immunization Monitoring Program, Active (IMPACT). Appropriately vaccinated children among hospitalized pertussis cases [abstract P73]. Presented at the Ninth Annual Conference on Vaccine Research; 2006 May 8-10; Baltimore.