Isoprostanes and asthma

Drug Discovery Today: Therapeutic Strategies

Volumn 3, Issue 3, 2006, Pages 287-292

  Montuschi, Paolo ^a   Barnes, Peter J ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 ISOPROSTAGLANDIN E2; 8 ISOPROSTAGLANDIN F2 ALPHA; ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIASTHMATIC AGENT; ANTIOXIDANT; ASCORBIC ACID; BECLOMETASONE; BETA CAROTENE; CATALASE; CORTICOSTEROID; FLUTICASONE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HOUSE DUST ALLERGEN; ISOPROSTANE DERIVATIVE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; OXIDOREDUCTASE INHIBITOR; PLACEBO; POLYPHENOL; PREDNISONE; REACTIVE OXYGEN METABOLITE; SELENIUM; SUPEROXIDE DISMUTASE; THIONEINE; THIOREDOXIN; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR; UNINDEXED DRUG;

ANTIOXIDANT ACTIVITY; ASTHMA; AVOIDANCE BEHAVIOR; BRONCHUS HYPERREACTIVITY; CHEMICAL STRUCTURE; CLINICAL FEATURE; CLINICAL TRIAL; DISEASE COURSE; DRUG EFFECT; DRUG TARGETING; HUMAN; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; RECEPTOR UPREGULATION; RESPIRATORY TRACT INFLAMMATION; REVIEW;

EID: 33751199691     PISSN: 17406773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddstr.2006.08.001     Document Type: Review

References (40)

1. Mak J.C.W., and Chan-Yeung M.M.W. Reactive oxidant species in asthma. Curr. Opin. Pulm. Med. 12 (2006) 7-11
2. Montuschi P., et al. Isoprostanes: markers and mediators of oxidative stress. FASEB J. 18 (2004) 1791-1800
3. 2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc. Natl. Acad. Sci. U S A 87 (1990) 9383-9387
4. Bochner B.S., and Busse W.W. Allergy and asthma. J. Allergy Clin. Immunol. 115 (2005) 953-959
5. Wood L.J., et al. Lipid peroxidation as determined by plasma isoprostanes is related to disease severity in mild asthma. Lipids 35 (2000) 967-974
6. Dworski R., et al. Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am. J. Respir. Crit. Care Med. 160 (1999) 1947-1951
7. 2α). Clin. Exp. Allergy 31 (2001) 387-390
8. Wood L.G., et al. Induced sputum 8-isoprostane concentrations in inflammatory airway diseases. Am. J. Respir. Crit. Care Med. 171 (2005) 426-430
9. Montuschi P., et al. Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. Am. J. Respir. Crit. Care Med. 160 (1999) 216-220
10. Kostikas K., et al. pH in expired breath condensate of patients with inflammatory airway diseases. Am. J. Respir. Crit. Care Med. 165 (2002) 1364-1370
11. Battaglia S., et al. Small airways function and molecular markers in exhaled air in mild asthma. Thorax 60 (2005) 639-644
12. Antczak A., et al. Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma. Am. J. Respir. Crit. Care Med. 166 (2002) 301-306
13. Montuschi P. Indirect monitoring of lung inflammation. Nat. Rev. Drug Discov. 1 (2002) 238-242
14. Mondino C., et al. Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children. J. Allergy Clin. Immunol. 114 (2004) 761-767
15. Baraldi E., et al. Increased exhaled 8-isoprostane in childhood asthma. Chest 124 (2003) 25-31
16. Shahid S.K., et al. Exhaled 8-isoprostane in childhood asthma. Respir. Res. 21 (2005) 79
17. Baraldi E., et al. Cysteinyl-leukotrienes and 8-isoprostane in exhaled breath condensate of children with asthma exacerbations. Thorax 58 (2003) 505-509
18. 2α, a novel noncyclooxygenase-derived prostaglandin, constricts airways in vitro. Am. J. Respir. Crit. Care Med. 153 (1996) 590-596
19. 2α induces airflow obstruction and airway plasma exudation in vivo. Am. J. Respir. Crit. Care Med. 155 (1997) 436-441
20. 2α in isolated perfused rat lung. J. Appl. Physiol. 74 (1993) 460-465
21. Held H.D., and Uhlig S. Mechanisms of endotoxin-induced airway and pulmonary vascular hyperreactivity in mice. Am. J. Respir. Crit. Care Med. 162 (2000) 1547-1552
22. Talati M., et al. Oxidant stress modulates murine allergic airway responses. Free Radic. Biol. Med. 40 (2006) 1210-1219
23. Janssen L.J. Isoprostanes: an overview and putative roles in pulmonary pathophysiology. Am. J. Physiol. Lung Cell Mol. Physiol. 280 (2001) L1067-L1082
24. Tazzeo T., et al. Vasoconstrictor responses, and underlying mechanisms, to isoprostanes in human and porcine bronchial arterial smooth muscle. Br. J. Pharmacol. 140 (2003) 759-763
25. 2α suppresses monocyte adhesion to human microvascular endothelial cells via two independent mechanisms. FASEB J. 19 (2005) 443-445
26. Janssen L.J., and Tazzeo T. Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature. J. Pharmacol. Exp. Ther. 301 (2002) 1060-1066
27. 2. Am. J. Physiol. 272 (1993) F477-F483
28. 2α, a potent agonist of the vasculature thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist. Prostaglandins 44 (1992) 155-163
29. 2α. J. Biol. Chem. 272 (1997) 27147-27154
30. Kirkham P., and Rahman I. Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacol. Ther. 111 (2006) 476-494
31. Pearson P.J., et al. Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial. Thorax 59 (2004) 652-656
32. Patel B.D., et al. Dietary antioxidants and asthma in adults. Thorax 61 (2006) 388-393
33. Fogarty A., et al. Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebo-controlled trial. Clin. Exp. Allergy 33 (2003) 1355-1359
34. Romieu I., et al. Antioxidant supplementation and lung functions among children with asthma exposed to high levels of air pollutants. Am. J. Respir. Crit. Care Med. 166 (2002) 703-709
35. Levine M., et al. A new recommended dietary allowance of vitamin C for healthy young women. Proc. Natl. Acad. Sci. U S A 98 (2001) 9842-9846
36. 2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N. Engl. J. Med. 332 (1995) 1198-1203
37. 2-isoprostanes in plasma of smokers. Cancer Epidemiol. Biomarkers Prev. 11 (2002) 7-13
38. 4 and prostanoids in children with asthma. J. Allergy Clin. Immunol. 118 (2006) 347-353
39. Bodini A., et al. Exhaled breath condensate eicosanoids and sputum eosinophils in asthmatic children: a pilot study. Pediatr. Allergy Immunol. 15 (2004) 26-31
40. 2-isoprostanes) are formed in situ on phospholipids. Proc. Natl. Acad. Sci. U S A 89 (1992) 10721-10725