Preparation of nanomagnetic absorbent for partition coefficient measurement

International Journal of Pharmaceutics

Volumn 327, Issue 1-2, 2006, Pages 139-144

  Tsang, Shik Chi ^a   Yu, Chih Hao ^a   Gao, Xin ^a   Tam, Kin Y ^b  

^a UNIVERSITY OF READING   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Magnetic nanoparticle; Magnetic separation; Partition coefficient; Porous; Supercritical fluid

Indexed keywords

4 NITROANISOLE; 4 NITROBENZYL ALCOHOL; 4 NITROPHENOL; ALCOHOL DERIVATIVE; BENZAMIDE; BUFFER; CARBON DIOXIDE; CHLORPROMAZINE; IMIPRAMINE; OCTANOL; QUINOLINE; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; DIFFUSION; DRUG DIFFUSION; DRUG MIXTURE; DRUG PENETRATION; EQUILIBRIUM CONSTANT; MAGNETIC SEPARATION; NANOPARTICLE; NANOTECHNOLOGY; PARTICLE SIZE; PARTITION COEFFICIENT; PERMEABILITY; PHYSICAL CHEMISTRY; POROSITY; PRIORITY JOURNAL; SUPERCRITICAL FLUID; SUSPENSION; ULTRAVIOLET SPECTROPHOTOMETRY;

1-OCTANOL; CARBON DIOXIDE; FERRIC COMPOUNDS; MAGNETICS; NANOPARTICLES; POROSITY; SILICON DIOXIDE; THERMOGRAVIMETRY; WATER;

EID: 33751087241     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.07.031     Document Type: Article

References (14)

1. Bu J., and Rhee H.K. Improvement in hydrophobicity of Ti-MCM-41 using a new silylation agent MSTFA. Catal. Lett. 65 (2000) 141-145
2. Comer J., Tam K., Testa B., Waterbeemd H.V.d., Folkers G., and Guy R. Pharmacokinetic Optimization in Drug Research-Lipophilicity Profiles: Theory and Measurement (2001), Wiley-VCH, Weinheim and reference therein
3. Danielsson L.G., and Zhang Y.H. Methods for determining n-octanol-water partition constants. Trac-Trends Anal. Chem. 15 (1996) 188-196
4. Gao X., Yu K.M.K., Tam K.Y., and Tsang S.C. Colloidal stable silica encapsulated nano-magnetic composite as a novel bio-catalyst carrier. Chem. Commun. 24 (2003) 2998-2999
5. Gao X., Yu C.H., Tam K.Y., and Tsang S.C. New magnetic nano-absorbent for the determination of n-octanol/water partition coefficients. J. Pharm. Biomed. Anal. 38 (2005) 197-203
6. Kamat S.V., Iwaskewycz B., Beckman E.J., and Russell A.J. Biocatalytic synthesis of acrylates in supercritical fluids-tuning enzyme-activity by changing pressure. Proc. Natl. Acad. Sci. USA 90 (1993) 2940-2944
7. Kamitsos E.I., Patsis A.P., and Kordas G. Infrared-reflectance spectra of heat-treated, sol-gel-derived silica. Phys. Rev. B 48 (1993) 12499-12505
8. Leo A., Hansch C., and Church C. Comparison of parameters currently used in the study of structure-activity relationships. J. Med. Chem. 12 (1969) 766-771
9. McHugh M.A., and Krukonis V.J. Supercritical Fluid Extraction-Principles and Practice (1986), Butterworths, Boston
10. Nakaya H., Miyawaki O., and Nakamura K. Determination of log P for pressurized carbon dioxide and its characterization as a medium for enzyme reaction. Enzyme Microb. Technol. 28 (2001) 176-182
11. Nam J.M., Thaxton C.S., and Mirkin C.A. Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science 301 (2003) 1884-1886
12. OECD, 1992. Guidelines for Testing of Chemicals, OECD ed., Paris.
13. Tsang S.C., Caps V., Paraskevas I., Chadwick D., and Thompsett D. Magnetically separable, carbon-supported nanocatalysts for the manufacture of fine chemicals. Angew Chem. Int. Ed. 43 (2004) 5645-5649
14. Tsang, S.C., Tam, K.Y., 2005. Composite nanoparticles. Filed by the University of Reading & Astrazeneca, UK, PCT Int. Appl. 54 pp. (WO 2005007284 at 2005 01 27).