Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis

Neurobiology of Disease

Volumn 25, Issue 1, 2007, Pages 8-16

  Andries, Maria ^a   Van Damme, Philip ^a   Robberecht, Wim ^a   Van Den Bosch, Ludo ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

AMPA receptor; Amyotrophic lateral sclerosis (ALS); ATP; Excitotoxicity; Ivermectin; Motoneuron; P2X4 receptor

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMPA RECEPTOR; CIBACRON BLUE F3GA; IVERMECTIN; KAINIC ACID; PURINE P2 RECEPTOR;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; EMBRYO; EXCITOTOXICITY; HYPOGLYCEMIA; HYPOXIA; IN VITRO STUDY; LIFESPAN; MOTONEURON; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSGENIC MOUSE;

ADENOSINE TRIPHOSPHATE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; HYPOGLYCEMIA; HYPOXIA, BRAIN; IVERMECTIN; KAINIC ACID; LONGEVITY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR NEURONS; PYRIDOXAL PHOSPHATE; RATS; RECEPTORS, AMPA; RECEPTORS, PURINERGIC P2; SUPEROXIDE DISMUTASE; TRIAZINES;

EID: 33751084365     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2006.08.018     Document Type: Article

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