Aldosterone and mineralocorticoid receptors: Lessons from gene deletion studies

Hypertension

Volumn 48, Issue 6, 2006, Pages 1018-1019

  Funder, John W ^a  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; CALCIUM; CHLORIDE; GLUCOCORTICOID RECEPTOR; MAGNESIUM; MINERALOCORTICOID RECEPTOR; POTASSIUM; SODIUM CHLORIDE; VASOPRESSIN;

ADRENALECTOMY; BINDING AFFINITY; CONCENTRATION (PARAMETERS); EDITORIAL; ELECTROLYTE DISTURBANCE; GENE DELETION; HIPPOCAMPUS; KNOCKOUT MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SALT INTAKE; URINE OSMOLALITY; URINE VOLUME; VASOPRESSIN BLOOD LEVEL; WILD TYPE;

ANIMALS; GENE DELETION; HUMANS; MICE; RECEPTORS, ALDOSTERONE; RECEPTORS, MINERALOCORTICOID;

EID: 33751082909     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000249855.29529.84     Document Type: Editorial

References (10)

1. Funder JW. The nongenomic actions of aldosterone. Endocr Rev. 2005;26:313-321.
2. Funder JW, Myles K. Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: in vivo binding studies. Endocrinology. 1996;137:5264-5268.
3. Funder JW. 15-Hydroxyprostaglandin dehydrogenase: Cinderella meets Prince Serendip. J Clin Endocrinol Metab. 1999;84:393-394.
4. Karst H, Berger S, Turiault M, Tronche F, Schutz G, Joels M. Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Proc Natl Acad Sci U S A. 2005;102:19204-19207.
5. Berger S, Wolfer DP, Selbach O, Alter H, Erdmann G, Reichardt HM, Chepkova AN, Welzl H, Haas HL, Lipp H-P, Schutz G. Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc Natl Acad Sci U S A. 2006;103:195-200.
6. Funder JW. Is aldosterone bad for the heart? Trends Endocrinol Metab. 2004;15:139-142.
7. Qin W, Rudolph A, Bond B, Rocha R, Blomme E, Goeliner J, Funder J, McMahon EG. A transgenic model of aldosterone-driven cardiac hypertrophy and heart failure. Circ Res. 2003;93:69-76.
8. Makhanova N, Sequeira-Lopez MLS, Gomez RA, Kim H-S, Smithies O. Disturbed homeostasis in sodium restricted mice heterozygous and homozygous for aldosterone synthase gene disruption. Hypertension. 2006;48:1151-1159.
9. + metabolism. Proc Natl Acad Sci U S A. 1998;95:9424-9429.
10. Makhanova N, Lee G, Takahashi N, Sequeira Lopez ML, Gomez RA, Kim H-S, Smithies O. Kidney function in mice lacking aldosterone. Am J Physiol. 2006;290:61-69.