Effect of the zinc chelator N,N,N′,N′-tetrakis (2 pyridylmethyl) ethylenediamine (TPEN) on hippocampal mossy fiber calcium signals and on synaptic transmission

Biological Research

Volumn 39, Issue 3, 2006, Pages 521-530

  Matias, Carlos M ^a,d   Matos, Nuno C ^b   Arif, Mona ^b   Dionisio, Jose C ^c   Quinta Ferreira, M Emilia ^d,e  

^a UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^b UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^c UNIVERSITY OF LISBON   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

^e UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Area CA1; Area CA3; Fura 2; Long term potentiation (LTP); Mossy fiber synapses; Presynaptic calcium

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CALCIUM; CHELATING AGENT; FURA 2; N METHYL DEXTRO ASPARTIC ACID; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; ZINC;

ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTRIC POTENTIAL; ELECTROSTIMULATION; HIPPOCAMPUS; LONG TERM POTENTIATION; NONHUMAN; PRESYNAPTIC NERVE; RAT; SYNAPSE; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION;

EID: 33751080597     PISSN: 07169760     EISSN: 07176287     Source Type: Journal    
DOI: 10.4067/S0716-97602006000300013     Document Type: Article

References (44)

1. AHN YH, KIM YH, HONG SH, KOH JY (1998) Depletion of intracellular zinc induces protein synthesis-dependent neuronal apoptosis in mouse cortical culture. Exp Neurol 154: 47-56
2. ARSLAN P, DI VIRGILIO F, BELTRAME M, TSIEN RY, POZZAN T (1985) Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+. J Biol Chem 260: 2719-2727
3. ARMSTRONG C, LEONG W, LEES GJ (2001) Comparative effects of metal chelating agents on the neuronal cytotoxicity induced by copper (Cu+2), iron (Fe+3) and zinc in the hippocampus. Brain Res 892: 51-62
4. ASSAF SY, CHUNG SH (1984) Release of endogenous Zn2+ from brain tissue during activity. Nature 308: 734-736
5. BANCILA V, NIKONENKO N, DUNANT Y, BLOC A (2004) Zinc inhibits glutamate release via activation of pre-synaptic K channels and reduces ischaemic damage in rat hippocampus J Neurochem 90: 1243-50
6. CANZONIERO LM, MANZERRA P, SHELINE CT, CHOI DW (2003) Membrane-permeant chelators can attenuate Zn2+-induced cortical neuronal death. Neuropharmacology 45: 420-428
7. CHOI DW, KOH JY (1998) Zinc and brain injury. Annu Rev Neurosci 21: 347-375
8. CLEMENS JD (1996) Transmitter timecourse in the synaptic cleft: its role in central synaptic function. TINS 19: 163-171
9. COLE TB, WENZEL HJ, KAFER KE, SCHWARTZKROIN PA, PALMITER RD (1999) Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Proc Natl Acad Sci USA 96: 1716-1721
10. CUAJUNGCO MP, LEES GJ (1997) Zinc metabolism in the brain: relevance to human neurodegenerative disorders. Neurobiol Dis 4: 137-169
11. CUAJUNGCO MP, LEES GJ (1998) Diverse effects of metal chelating agents on the neuronal cytotoxicity of zinc in the hippocampus. Brain Res 799: 97-107
12. FREDERICKSON CJ (1989) Neurobiology of zinc and zinc-containing neurons. Int. Rev. Neurobiol. 31: 145-238
13. FREDERICKSON CJ, DANSCHER G (1990) Zinc-containing neurons in hippocampus and related CNS structures. Prog Brain Res 83: 71-84
14. FREDERICKSON CJ, SUH SW, SILVA D, FREDERICKSON CJ, THOMPSON RB (2000) Importance of zinc in the central nervous system: the zinc-containing neuron. J Nutr 130: 1471S-1483S
15. FREDERICKSON CJ, KOH JY, BUSH AI (2005) The neurobiology of zinc in health and disease. Nat Rev Neurosci 6: 449-462
16. GRYNKIEWICZ G, POENIE M, TSIEN RY (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450
17. 2+: An endogenous modulator of ligand- and voltagegated ion channels. Neuropharmacology 33: 935-952
18. HOWELL GA, WELCH MG, FREDERICKSON CJ (1984) Stimulation-induced uptake and release of zinc in hippocampal slices. Nature 308: 736-738
19. KAMIYA Y, OZAWA S (1999) Dual mechanism for presynaptic modulation by axonal metabotropic glutamate receptor at the mouse mossy fibre-CA3 synapse. J Physiol 518: 497-506
20. KHULUSI S, BROWN M, WRIGHT M (1986) Zinc and paired-pulse potentiation in the hippocampus. Brain Res 363: 152-155
21. LI Y, HOUGH CJ, FREDERICKSON CJ, SARVEY JM (2001a) Induction of mossy fiber -> Ca3 long-term potentiation requires translocation of synaptically released Zn2. J Neurosci 21: 8015-8025
22. LI Y, HOUGH CJ, SUH SH, FREDERICKSON CJ, SARVEY JM (2001b) Rapid translocation of Zn(2+) from presynaptic terminals into postsynaptic hippocampal neurons after physiological stimulation. J Neurophysiol 86: 2597-2604
23. LOPANTSEV V, WENZEL HJ, COLE TB, PALMITER RD, SCHWARTZKROIN PA (2003) Lack of vesicular zinc in mossy fibers does not affect synaptic excitability of CA3 pyramidal cells in zinc transporter 3 knockout mice. Neuroscience 116: 237-248
24. LU YM, TAVERNA FA, TU R., ACKERLEY CA, WANG YT, RODER J (2000) Endogenous Zn (2+). is required for the induction of long-term potentiation at rat hippocampal mossy fiber-CA3 synapses. Synapse 38: 187-197
25. MARÍN P, ISRAEL M, GLOWINSKI M, PREMONT J (2000) Routes of zinc entry in mouse cortical neurons: role in zinc-induced neurotoxicity. Eur J Neurosci 12: 8-18
26. MOURRE C, WIDMANN C, LAZDUNSKI M (1991) Specific hippocampal lesions indicate the presence of sulfonylurea binding sites associated to ATP-sensitive K+ channels both postsynaptically and on mossy fibers. Brain Res 540: 340-344
27. NICOLL RA, MALENKA RC (1995) Contrasting properties of two forms of long-term potentiation in the hippocampus. Nature 377: 115-118
28. QUINTA-FERREIRA ME, MATIAS CM (2002) Zinc inhibits presynaptic calcium influxes in CA3 but not in CA1 hippocampal area. FENS Abstr 1: A115.12
29. QUINTA-FERREIRA ME, MATIAS CM (2004) Presynaptic calcium changes are maintained during hippocampal mossy fiber long-term potentiation and are inhibited by endogenous zinc. Brain Res 1004: 52-60
30. QUINTA-FERREIRA ME, MATIAS CM, ARIF M, DIONISIO JC (2004) Measurement of presynaptic zinc changes in hippocampal mossy fibers. Brain Res 1026: 1-10
31. QUINTA-FERREIRA ME, MATIAS CM (2005) Tetanically released zinc inhibits hippocampal mossy fiber calcium, zinc and synaptic responses. Brain Res 1047: 1-9
32. RUIZ A, WALKER M, FABIAN-FINE R, KULLMANN D (2004) Endogenous zinc inhibits GABA (A) receptors in a hippocampal pathway. Neurophysiol 91: 1091-1096
33. SENSI SL, CANZONIERO LM, YU SP, YING HS, KOH JY, KERCHNER GA, CHOI DW (1997) Measurement of intracellular free zinc in living cortical neurons: routes of entry. J Neurosci 17(24): 9554-64
34. SMART TG, XIE X, KRISHEK BJ (1994) Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc. Progr Neurobiol 42: 393-441
35. SUDHOF TC (1995) The synaptic vesicle cycle: A cascade of protein-protein interactions. Nature 375: 645-653
36. TREMBLAY E, ZINI S, BEN-ARI Y (1991) Autoradiographic study of the cellular localization of [3H]glibenclamide binding sites in the rat hippocampus. Neurosci Lett 127: 21-24
37. VALLEE BL, FALCHUK KH (1993) The biochemical basis of zinc physiology. Physiol Rev 73: 79-118
38. VEGA MT, VILLALOBOS C, GARRIDO B, GANDIA L, BULBENA O, GARCÍA-SANCHO J, GARCÍA AG, ARTALEJO AR (1994) Permeation by zinc of bovine chromaffin cell calcium channels: relevance to secretion. Pflügerş Arch 429: 231-239
39. VOGT K, MELLOR J, TONG G, NICOLL R (2000) The actions of synaptically released zinc at hippocampal mossy fiber synapses. Neuron 26: 187-196
40. +: A novel ionic mediator of neural injury in brain disease. TIPS 21: 395-401
41. WENSINK J, LENGLET WJ, WIS RD, VAN DEN HAMER CJ (1987) The effect of dietary zinc deficiency on the mossy fiber zinc content of the rat hippocampus. A microbeam PIXE study. Particle Induced X-Ray Emission. Histochemistry 87: 65-69
42. WU LG, SAGGAU P (1997) Presynaptic inhibition of elicited neurotransmitter release. TINS 20: 204-212
43. XIE X, SMART TG (1994) Modulation of long-term potentiation in rat hippocampal pyramidal neurons by zinc. Pflugers Arch. 427: 481-486
44. ZAWAR C, PLANT TD, SCHIRRA C, KONNERTH A, NEMCKE B (1999) Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus. J Physiol 514: 327-341