Evaluation of a surgical procedure to measure drug biliary excretion of rats in regulatory safety studies

Fundamental and Clinical Pharmacology

Volumn 20, Issue 6, 2006, Pages 587-593

  Faure, Laurence ^a   Vignand, Philippe ^a   Raynard, Alain ^a   Pasello Legrand, Flavia ^a   Descotes, Jacques ^b  

^a MDS Pharma Services   (France)

^b Poison Center   (France)

Author keywords

Animal model; Biliary duct cannulation; Histology; Liver function tests; Rat

Indexed keywords

BILE SALT; CARBON 14; DIAZEPAM; IMMUNOSUPPRESSIVE AGENT; LIVER ENZYME; TSUKUBAENOLIDE;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ARTICLE; BILE DUCT; BILE FLOW; CATHETER; CONTROLLED STUDY; DRUG EXCRETION; DRUG LEGISLATION; DRUG REEXPOSURE; DRUG SAFETY; ENZYME BLOOD LEVEL; EVALUATION; FEMALE; MALE; MEASUREMENT; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; SURGICAL TECHNIQUE;

ANIMALS; ANTI-ANXIETY AGENTS; BILE ACIDS AND SALTS; BILIARY TRACT SURGICAL PROCEDURES; DIAZEPAM; DRUG EVALUATION, PRECLINICAL; FEMALE; HEALTH STATUS; IMMUNOSUPPRESSIVE AGENTS; LIVER; MALE; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; TACROLIMUS;

EID: 33751069949     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2006.00446.x     Document Type: Article

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