Naive CD4+ T cells and recent thymic emigrant levels in treated individuals with HIV: Clinical relevance

AIDS Research and Human Retroviruses

Volumn 22, Issue 9, 2006, Pages 893-896

  Bofill, Margarita ^a   Martinez Picado, Javier ^a   Ruiz Hernandez, Raul ^a   Cabrera, Cecilia ^a   Marfil, Silvia ^a   Erkizia, Itziar ^a   Bellido, Rocio ^a   Romeu, Joan ^a   Clotet, Bonaventura ^a   Ruiz, Lidia ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD31 ANTIGEN; CD4 ANTIGEN; CD45RA ANTIGEN; GAG PROTEIN; VIRUS ANTIGEN;

ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KAPLAN MEIER METHOD; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL RATE; THYMUS; TREATMENT OUTCOME;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; HIV INFECTIONS; HUMANS; PREDICTIVE VALUE OF TESTS; SURVIVAL ANALYSIS; THYMUS GLAND; TREATMENT OUTCOME;

EID: 33751053809     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2006.22.893     Document Type: Article

References (14)

1. Nicastri E, Chiesi A, Angeletti C, et al.: Clinical outcome after 4 years follow-up of HIV-seropositive subjects with incomplete virologic or immunologic response to HAART. J Med Virol 2005;76:153-160.
2. + T cell counts and plasma HIV-1 RNA levels. 10th Conference on Retroviruses and Opportunistes Infections. Boston, Feburary 10-14, 2003 (abstract 183).
3. Kimmig S, Przybylski GK, Schmidt CA, et al.: Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J Exp Med 2002;195:789-794.
4. Diaz M, Douek DC, Valdez H, et al.: T cells containing T cell receptor excision circles are inversely related to HIV replication and are selectively and rapidly released into circulation with antiretroviral treatment. AIDS 2003;17:1145-1149.
5. Slyker JA, Lohman BL, Mbori-Ngacha DA, et al.: Modified vaccinia Ankara expressing HIVA antigen stimulates HIV-1-specific CD8 T cells in ELISpot assays of HIV-1 exposed infants. Vaccine 2005;23:4711-4719.
6. Clerici M, Lucey DR, Berzofsky JA, et al.: Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 1993;262:1721-1724.
7. Harari A, Vallelian F, Meylan PR, and Pantaleo G: Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence. J Immunol 2005;174:1037-1045.
8. Lange CG and Lederman MM: Immune reconstitution with antiretroviral therapies in chronic HIV-1 infection. J Antimicrob Chemother 2003;51:1-4.
9. Pakker NG, Notermans DW, de Boer RJ, et al.: Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation. Nat Med 1998;4:208-214.
10. +) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J Clin Invest 1999;103:1391-1398.
11. Akbar AN, Terry L, Timms A, Beverley PC, and Janossy G: Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol 1988;140:2171-2178.
12. Demoustier A, Gubler B, Lambone O, et al.: In patients on prolonged HAART, a significant pool of HIV infected CD4 T cells are HIV-specific. AIDS 2002;16:1749-1754.
13. Bonyhadi ML, Rabin L, Salimi S, et al.: HIV induces thymus depletion in vivo. Nature 1993;363:728-732.
14. Maggiolo F, Ripamonti D, Gregis G, Quinzan G, Callegaro A, and Suter F: Effect of prolonged discontinuation of successful antiretroviral therapy on CD4 T cells: A controlled, prospective trial. AIDS 2004;18:439-446.