What should we weigh to estimate heterozygosity, alleles or loci?

Molecular Ecology

Volumn 15, Issue 14, 2006, Pages 4659-4665

  Aparicio, J M ^a   Ortego, J ^a   Cordero, P J ^a  

^a INSTITUTO DE INVESTIGACIÓN EN RECURSOS CINEGÉTICOS IREC CSIC UCLM JCCM   (Spain)

Author keywords

Heterozygosity; Homozygosity by loci; Homozygosity indexes; Inbreeding; Internal relatedness; Molecular markers

Indexed keywords

MICROSATELLITE DNA;

ALLELE; ARTICLE; BIOLOGICAL MODEL; GENETIC MARKER; GENETICS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; STATISTICAL MODEL;

ALLELES; GENETIC MARKERS; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LINEAR MODELS; MICROSATELLITE REPEATS; MODELS, GENETIC;

EID: 33751021406     PISSN: 09621083     EISSN: 1365294X     Source Type: Journal    
DOI: 10.1111/j.1365-294X.2006.03111.x     Document Type: Article

References (22)

1. Acevedo-Whitehouse K, Gulland F, Greig D, Amos W (2003) Disease susceptibility in California sea lions. Nature, 422, 35-35.
2. Amos W, Wilmer J, Fullard K et al. (2001) The influence of parental relatedness on reproductive success. Proceedings of the Royal Society of London. Series B, Biological Sciences, 268, 2021-2027.
3. Aparicio JM, Cordero PJ, Veiga JP (2001) A test of the hypothesis of mate choice based on heterozygosity in the spotless starling. Animal Behaviour, 62, 1001-1005.
4. Balloux F, Amos W, Coulson T (2004) Does heterozygosity estimate inbreeding in real populations? Molecular Ecology, 13, 3021-3031.
5. Coltman DW, Pilkington JG, Smith JA, Pemberton JM (1999) Parasite-mediated selection against inbred Soay sheep in a free-living, island population. Evolution, 53, 1259-1267.
6. Coltman D, Slate J (2003) Microsatellite measures of inbreeding: a meta-analysis. Evolution, 57, 971-983.
7. Cordero PJ, Aparicio JM, Veiga JP (2004) Parental genetic characteristics and hatching success in the spotless starling, Sturnus unicolor. Animal Behaviour, 67, 637-642.
8. Coulson, TN, Pemberton JM, Albon SD et al. (1998) Microsatellites reveal heterosis in red deer. Proceedings of the Royal Society of London. Series B, Biological Sciences, 268, 2021-2027.
9. Goudet J, Keller L (2002) The correlation between inbreeding and fitness: does allele size matter? Trends in Ecology & Evolution, 17, 201-202.
10. Hansson B, Bensch S, Hasselquist D, Akesson M (2001) Microsatellite diversity predicts recruitment of sibling great reed warblers. Proceedings of the Royal Society of London. Series B, Biological Sciences, 268, 1287-1291.
11. Hansson B, Bensch S, Hasselquist D (2003) A new approach to study dispersal: immigration of novel alleles reveals female biased dispersal in great reed warblers. Molecular Ecology, 12, 631-637.
12. Hedrick P, Fredrickson R, Ellegren H (2001) Evaluation of d2, a microsatellite measure of inbreeding and outbreeding, in wolves with a known pedigree. Evolution, 55, 1254-1260.
13. Höglund J, Piertney SB, Alatalo RV, Lindell J, Lundberg A, Rintamaki PT (2001) Inbreeding depression and male fitness in black grouse. Proceedings of the Royal Society of London. Series B, Biological Sciences, 269, 711-715.
14. Pemberton J (2004) Measuring inbreeding depression in the wild: the old ways are the best. Trends in Ecology & Evolution, 19, 613-615.
15. Pemberton J, Coltman D, Coulson T, Slate J (1999) Using microsatellites to measure the fitness consequences of inbreeding and outbreeding. In: Microsatellites, Evolution and Applications (eds Goldstein D, Schlotterer C), pp. 151-164. Oxford University Press, Oxford.
16. Queller DC, Goodnight KF (1989) Estimating relatedness using genetic markers. Evolution, 43, 258-275.
17. Roberts SC, Hale ML, Petrie M (2006) Correlations between heterozygosity and measures of genetic similarity: implications for understanding mate choice. Journal of Evolutionary Biology, 19, 558-569.
18. Slate J, David P, Dodds KG et al. (2004) Understanding the relationship between the inbreeding coefficient and multilocus heterozygosity: theoretical expectations and empirical data. Heredity, 93, 255-265.
19. Slate J, Pemberton JM (2002) Comparing molecular measures for detecting inbreeding depression. Journal of Evolutionary Biology, 15, 20-31.
20. Tsitrone A, Rousset F, David P (2001) Heterosis, marker mutational processes and population inbreeding history. Genetics, 159, 1845-1859.
21. Walpole RE, Myers RH (1978) Probability and Statistics for Engineers and Scientists, 2nd edn. MacMillan Publishing Co, New York.
22. Zar JH (1984) Biostatistical Analysis. Prentice Hall International, Englewood Cliffs, New Jersey.