Why the most potent toxin may heal anal fissure

Advances in Therapy

Volumn 23, Issue 4, 2006, Pages 627-634

  Madalinski, Mariusz ^a,c   Chodorowski, Zygmunt ^b  

^a St John Hospital   (Poland)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c NONE   (Poland)

Author keywords

Anal fissure; Botulinum toxin; Internal anal sphincter; Ischemic ulcer

Indexed keywords

BOTULINUM TOXIN A;

ANAL COMPLAINT; ANUS FISSURE; ANUS SPHINCTER; BLOOD FLOW; DRUG EFFECT; DRUG MECHANISM; HUMAN; REVIEW; TREATMENT OUTCOME;

EID: 33751021098     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02850051     Document Type: Review

References (52)

1. Jost WH, Schimrigk K. Use of botulinum toxin in anal fissure. Dis Colon Rectum. 1993;36:974.
2. American Gastroenterological Association. American Gastroenterological Association medical position statement: diagnosis and care of patients with anal fissure. Gastroenterology. 2003;124:233-234.
3. Madoff RD, Fleshman JW. AGA technical review on the diagnosis and care of patients with anal fissure. Gastroenterology. 2003;124:235-245.
4. Lund JN, Scholefield JH. Aetiology and treatment of anal fissure. Br J Surg. 1996;83:1335-1344.
5. Delco F, Sonnenberg A. Association between hemorrhoids and other diagnoses. Dis Colon Rectum. 1998;41:1534-1542.
6. Miles W. Observations upon internal piles. Surg Gynecol Obstet. 1919;29:497-506.
7. Maria G, Brisinda D, Ruggieri MP, Civello IM, Brisinda G. Identification of anti-endothelial cell antibodies in patients with chronic anal fissure. Surgery. 1999;126:535-540.
8. Klosterhalfen B, Vogel P, Rixen H, Mittermayer C. Topography of the inferior rectal artery: a possible cause of chronic, primary anal fissure. Dis Colon Rectum. 1989;32:43-52.
9. Schouten WR, Briel JW, Auwerda JJ. Relationship between anal pressure and anodermal blood flow: the vascular pathogenesis of anal fissures. Dis Colon Rectum. 1994;37:664-669.
10. Minguez M, Herreros B, Espi A, et al. Long-term follow-up (42 months) of chronic anal fissure after healing with botulinum toxin. Gastroenterology. 2002;123:112-117.
11. Nelson R. A systematic review of medical therapy for anal fissure. Dis Colon Rectum. 2004;47:422-431.
12. Gui D, Rossi S, Runfola M, Magalini SC. Review article: botulinum toxin in the therapy of gastrointestinal motility disorders. Aliment Pharmacol Ther. 2003;18:1-16.
13. Lamanna C. The most poisonous poison. Science. 1959;130:763-772.
14. Shapiro RL, Hatheway C, Swerdlow D. Botulism in the United States: a clinical and epidemiological review. Ann Intern Med. 1998;129:221-228.
15. Schantz EJ, Johnson EA. Properties and use of botulinum toxin and other microbial neurotoxins in medicine. Microbiol Rev. 1992;56:80-99.
16. Singh BR. Molecular basis of the unique endopeptidase activity of botulinum neurotoxin. In: Brin MF, Hallet M, Jankovich J, eds. Scientific and Therapeutic Aspects of Botulinum Toxin. Philadelphia, Pa: Lippincott, Williams & Wilkins; 2002:75-88.
17. Borodic GE, Ferrante RJ, Pearce LB, Alderson K. Pharmacology and histology of the therapeutic application of botulinum toxin. In: Jankovich J, Hallet M, eds. Therapy with Botulinum Toxin. New York, NY: Marcel Dekker Inc; 1994:119-157.
18. Shaari CM, George E, Wu BL, Biller HF, Sanders I. Quantifying the spread of botulinum toxin through muscle fascia. Laryngoscope. 1991;101:960-964.
19. Shaari CM, Sanders I. Quantifying how location and dose of botulinum toxin injections affect muscle paralysis. Muscle Nerve. 1993;16:964-969.
20. Munchau A, Bhatia KP. Uses of botulinum toxin injection in medicine today. BMJ. 2000;320:161-165.
21. Hasler WL. The expanding spectrum of clinical uses for botulinum toxin: healing of chronic anal fissures. Gastroenterology. 1999;116:221-223.
22. Jost WH, Schimrigk K. Botulinum toxin in therapy of anal fissure. Lancet. 1995;345:188-189.
23. Gui D, Cassetta E, Anastasio G, Bentivoglio AR, Maria G, Albanese A. Botulinum toxin for chronic anal fissure. Lancet. 1994;344:1127-1128.
24. Maria G, Brisinda G, Bentivoglio AR, Cassetta E, Gui D, Albanese A. Botulinum toxin injections in the internal anal sphincter for the treatment of chronic anal fissure: long-term results after two different dosage regimens. Ann Surg. 1998;228:664-669.
25. Brisinda G, Maria G, Bentivoglio AR, Cassetta E, Gui D, Albanese A. A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. N Engl J Med. 1999;341:65-69.
26. Madalinski M. Nonsurgical treatment modalities for chronic anal fissure using botulinum toxin. Gastroenterology. 1999;117:516-517.
27. Schafer A, Enck P, Furst G, Kahn T, Frieling T, Lubke HJ. Anatomy of the anal sphincters: comparison of anal endosonography to magnetic resonance imaging. Dis Colon Rectum. 1994;37:777-781.
28. Madalinski M. Botox and Dysport are distinct. Endoscopy. 2000;32:502-503.
29. Aoki KR. Immunologic and other properties of therapeutic botulinum toxin serotypes: scientific and therapeutic aspects of botulinum toxin. In: Brin MF, Hallet M, Jankovich J, eds. Scientific and Therapeutic Aspects of Botulinum Toxin. Philadelphia, Pa: Lippincott Williams & Wilkins; 2002: 103-113.
30. Brisinda G, Albanese A, Cadeddu F, et al. Botulinum neurotoxin to treat chronic anal fissure: results of a randomized "Botox vs. Dysport" controlled trial. Aliment Pharmacol Ther. 2004;19:695-701.
31. Madalinski M. The treatment algorithm instead of the unknown optimal dose of botulinum toxin for chronic anal fissure. Aliment Pharmacol Ther. 2004;20:125.
32. Brisinda G, Cadeddu F, Brandara F, Brisinda D, Maria G. Treating chronic anal fissure with botulinum neurotoxin. Nat Clin Pract Gastroenterol Hepatol. 2004;1:82-89.
33. Madalinski M, Slawek J. The higher doses of botulinum toxin and the potentiate effect of its action after nitric oxide donors' application for the treatment of chronic anal fissure. Surgery. 2003;133:455.
34. Madalinski M. Higher or lower doses of botulinum toxin for the treatment of chronic anal fissure? Gastroenterology. 2003;124:1165.
35. Madalinski MH, Slawek J, Duzynski W, et al. Side effects of botulinum toxin injection for benign anal disorders. Eur J Gastroenterol Hepatol. 2002;14:853-856.
36. Maria G, Brisinda G, Bentivoglio AR, Cassetta E, Gui D, Albanese A. Influence of botulinum toxin site of injections on healing rate in patients with chronic anal fissure. Am J Surg. 2000;179:46-50.
37. Madalinski M, Jagiello K, Labon M, Adrich Z, Kryszewski A. Botulinum toxin injection into only one point in the external anal sphincter: a modification of the treatment for chronic anal fissure. Endoscopy. 1999;31:S63.
38. Acquadro MA. Borodic GE. Treatment of myofascial pain with botulinum A toxin. Anesthesiology. 1994;80:705-706.
39. Sycha T, Kranz G, Auff E, Schnider P. Botulinum toxin in the treatment of rare head and neck pain syndromes: a systematic review of the literature. J Neurol. 2004;251(suppl 1):I19-I30.
40. Jones OM, Brading AF, Mortensen NJ. Mechanism of action of botulinum toxin on the internal anal sphincter. Br J Surg. 2004;91:224-228.
41. Madalinski MH, Slawek J, Zbytek B, et al. Topical nitrates and the higher doses of botulinum toxin for chronic anal fissure. Hepatogastroenterology. 2001;48:977-979.
42. Madalinski M, Adrich Z, Kryszewski A. Nitric oxide donors and their potentiating effects after botulinum toxin application for treatment of chronic anal fissure. Pol Arch Med Wewn. 2002;107:69-74.
43. O'Kelly T, Brading A, Mortensen N. Nerve mediated relaxation of the human internal anal sphincter: the role of nitric oxide. Gut. 1993;34:689-693.
44. Madalinski M, Chodorowski Z. Relation between botulinum toxin and nitric oxide donors in the treatment of the chronic anal fissure. Med Sci Monit. 2005;11:1-5.
45. Lund JN. Nitric oxide deficiency in the internal anal sphincter of patients with chronic anal fissure. Int J Colorectal Dis. 2006;21:673-675.
46. Thornton J, Kennedy ML, King DW. Prospective manometric assessment of botulinum toxin and its correlation with healing of chronic anal fissure. Dis Colon Rectum. 2005;48:1207-1212.
47. Ho KS, Ho YH. Randomized clinical trial comparing oral nifedipine with lateral anal sphincterotomy and tailored sphincterotomy in the treatment of chronic anal fissure. Br J Surg. 2005;92:403-408.
48. Boulos PB, Araujo JG. Adequate internal sphincterotomy for chronic anal fissure: subcutaneous or open technique? Br J Surg. 1984;71:360-362.
49. Chowcat NL, Araujo JG, Boulos PB. Internal sphincterotomy for chronic anal fissure: long term effects on anal pressure. Br J Surg. 1986;73:915-916.
50. Bassenge E. Endothelial function in different organs. Prog Cardiovasc Dis. 1996;39:209-228.
51. Rosales RL, Arimura K, Takenaga S, et al. Extrafusal and intrafusal muscle effects in experimental botulinum toxin-A injection. Muscle Nerve. 1996;19:488-496.
52. Mentes BB, Ege B, Laventoglu S, Oguz M, Karadag A. Extent of lateral internal sphincterotomy: up to the dentate line or up to the fissure apex? Dis Colon Rectum. 2005;48:365-370.