Noninvasive evaluation of liver repopulation by transplanted hepatocytes using 31P MRS imaging in mice

Hepatology

Volumn 44, Issue 5, 2006, Pages 1250-1258

  Landis, Charles S ^a   Yamanouchi, Kosho ^a   Zhou, Hongchao ^a   Mohan, Sankar ^a   Roy Chowdhury, Namita ^a   Shafritz, David A ^a   Koretsky, Alan ^b   Roy Chowdhury, Jayanta ^a   Hetherington, Hoby P ^a   Guha, Chandan ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; CREATINE PHOSPHATE; SCATTER FACTOR;

ADENOVIRUS VECTOR; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEPATOCYTE TRANSPLANTATION; IMAGING; IRRADIATION; MARKER GENE; MOUSE; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECTROSCOPY;

ANIMALS; CELL DIVISION; CREATINE KINASE; GENE EXPRESSION; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; HUMANS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, TRANSGENIC; PHOSPHOCREATINE; PHOSPHORUS; RADIATION DOSAGE; REGRESSION ANALYSIS; TRANSGENES; TRANSPLANTATION CONDITIONING;

EID: 33751010492     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21382     Document Type: Article

References (37)

1. Guha C, Ghosh SS, Lee SL, Roy-Chowdhury N, Roy-Chowdhury J. Hepatocyte transplantation and liver-directed gene therapy. In: Trauner M, Jansen PLM, eds. Molecular Pathogenesis of Cholestasis. Georgetown, TX: Landes Bioscience, 2003:340-360.
2. Gupta S, Chowdhury JR. Therapeutic potential of hepatocyte transplantation. Semin Cell Dev Biol 2002;13:439-446.
3. Gupta S, Inada M, Joseph B, Kumaran V, Benten D. Emerging insights into liver-directed cell therapy for genetic and acquired disorders. Transpl Immunol 2004;12:289-302.
4. Fox IJ, Chowdhury JR. Hepatocyte transplantation. Am J Transplant 2004;(Suppl 6):7-13.
5. Shah K, Jacobs A, Breakefield XO, Weissleder R. Molecular imaging of gene therapy for cancer. Gene Ther 2004;11:1175-1187.
6. Weissleder R, Ntziachristos V. Shedding light onto live molecular targets. Nat Med 2003;9:123-128.
7. Liu HS, Jan MS, Chou CK, Chen PH, Ke NJ. Is green fluorescent protein toxic to the living cells? Biochem Biophys Res Commun 1999;260:712-717.
8. Cao B, Bruder J, Kovesdi I, Huard J. Muscle stem cells can act as antigen-presenting cells: implication for gene therapy. Gene Ther 2004;11:1321-1330.
9. Herweijer H, Zhang G, Subbotin VM, Budker V, Williams P, Wolff JA. Time course of gene expression after plasmid DNA gene transfer to the liver. J Gene Med 2001;3:280-291.
10. Sullivan DE, Dash S, Du H, Hiramatsu N, Aydin F, Kolls J, et al. Liver-directed gene transfer in non-human primates. Hum Gene Ther 1997;8:1195-1206.
11. Blasberg R. PET imaging of gene expression. Eur J Cancer 2002;38:2137-2146.
12. Matuszewski L, Persigehl T, Wall A, Schwindt W, Tombach B, Fobker M, et al. Cell tagging with clinically approved iron oxides: feasibility and effect of lipofection, particle size, and surface coating on labeling efficiency. Radiology 2005;235:155-161.
13. Shapiro EM, Skrtic S, Koretsky AP. Sizing it up: cellular MRI using micron-sized iron oxide particles. Magn Reson Med 2005;53:329-338.
14. Koretsky AP, Brosnan MJ, Chen LH, Chen JD, Van Dyke T. NMR detection of creatine kinase expressed in liver of transgenic mice: determination of free ADP levels. Proc Natl Acad Sci U S A 1990;87:3112-3116.
15. Guha C, Sharma A, Gupta S, Alfieri A, Gorla GR, Gagandeep S, et al. Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation. Cancer Res 1999;59:5871-5874.
16. Deb NJ, Kawashita Y, Shah SJ, Roy-Chowdhury N, Liu L, Gorla GR, et al. Selective hepatic lobar repopulation by transplanted hepatocytes after ligation of a portal vein branch and preparative hepatic irradiation. HEPATOLOGY 2001;34:153A.
17. Guha C, Parashar B, Deb NJ, Garg M, Gorla GR, Singh A, et al. Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resection. HEPATOLOGY 2002;36:354-362.
18. Takahashi M, Deb NJ, Kawashita Y, Lee SW, Furgueil J, Okuyama T, et al. A novel strategy for in vivo expansion of transplanted hepatocytes using preparative hepatic irradiation and FasL-induced hepatocellular apoptosis. Gene Ther 2003;10:304-313.
19. Guha C, Yamanouchi K, Jiang J, Wang X, Roy Chowdhury N, Santana A, et al. Feasibility of hepatocyte transplantation-based therapies for primary hyperoxalurias. Am J Nephrol 2005;25:161-170.
20. Berry MN, Friend DS. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol 1969;43:506-520.
21. Neufeld DS. Isolation of Rat Hepatocytes. Totowa, NJ: Humana Press Inc, 1997.
22. Barker PB, Butterworth EJ, Boska MD, Nelson J, Welch KM. Magnesium and pH imaging of the human brain at 3.0 Tesla. Magn Reson Med 1999;41:400-406.
23. Oliver IT. A spectrophotometric method for the determination of creatine phosphokinase and myokinase. Biochem J 1955;61:116-122.
24. Ipsiroglu OS, Stromberger C, Ilas J, Hoger H, Muhl A, Stockler-Ipsiroglu S. Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species. Life Sci 2001;69:1805-1815.
25. Zakian KL, Koutcher JA, Malhotra S, Thaler H, Jarnagin W, Schwartz L, et al. Liver regeneration in humans is characterized by significant changes in cellular phosphorus metabolism: assessment using proton-decoupled 31P-magnetic resonance spectroscopic imaging. Magn Reson Med 2005;54:264-271.
26. Corbin IR, Buist R, Volotovskyy V, Peeling J, Zhang M, Minuk GY. Regenerative activity and liver function following partial hepatectomy in the rat using (31)P-MR spectroscopy. HEPATOLOGY 2002;36:345-353.
27. Auricchio A, Zhou R, Wilson JM, Glickson JD. In vivo detection of gene expression in liver by 31P nuclear magnetic resonance spectroscopy employing creatine kinase as a marker gene. Proc Natl Acad Sci U S A 2001;98:5205-5210.
28. Li Z, Qiao H, Lebherz C, Choi SR, Zhou X, Gao G, et al. Creatine kinase, a magnetic resonance-detectable marker gene for quantification of liver-directed gene transfer. Hum Gene Ther 2005;16:1429-1438.
29. Bottomley PA, Ouwerkerk R, Lee RF, Weiss RG. Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo. Magn Reson Med 2002;47:850-863.
30. Askenasy N, Koretsky AP. Differential effects of creatine kinase isoenzymes and substrates on regeneration in livers of transgenic mice. Am J Physiol 1997;273:C741-C746.
31. Kishore P, Gabriely I, Cui MH, Di Vito J, Gajavelli S, Hwang JH, et al. Role of hepatic glycogen breakdown in defective counterregulation of hypoglycemia in intensively treated type 1 diabetes. Diabetes 2006;55:659-666.
32. Laconi E, Oren R, Mukhopadhyay DK, Hurston E, Laconi S, Pani P, et al. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol 1998;153:319-329.
33. Oren R, Dabeva MD, Karnezis AN, Petkov PM, Rosencrantz R, Sandhu JP, et al. Role of thyroid hormone in stimulating liver repopulation in the rat by transplanted hepatocytes. HEPATOLOGY 1999;30:903-913.
34. Mignon A, Guidotti JE, Mitchell C, Fabre M, Wernet A, De La Coste A, et al. Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes. Nat Med 1998;4:1185-1188.
35. Mitchell C, Mignon A, Guidotti JE, Besnard S, Fabre M, Duverger N, et al. Therapeutic liver repopulation in a mouse model of hypercholesterolemia. Hum Mol Genet 2000;9:1597-1602.
36. Brosnan MJ, Chen L, Van Dyke TA, Koretsky AP. Free ADP levels in transgenic mouse liver expressing creatine kinase. Effects of enzyme activity, phosphagen type, and substrate concentration. J Biol Chem 1990;265:20849-20855.
37. Hetherington HP, Luney DJ, Vaughan JT, Pan JW, Ponder SL, Tschendel O, et al. 3D 31P spectroscopic imaging of the human heart at 4.1 T. Magn Reson Med 1995;33:427-431.