Methadone-induced long QT syndrome vs methadone-induced torsades de pointes [7]

Archives of Internal Medicine

Volumn 166, Issue 20, 2006, Pages 2288-

  Justo, Dan ^a  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; METHADONE;

COMBINATION CHEMOTHERAPY; DISEASE ASSOCIATION; DRUG MEGADOSE; DRUG USE; FOOD AND DRUG ADMINISTRATION; HUMAN; HYPOKALEMIA; LETTER; LIVER DYSFUNCTION; LONG QT SYNDROME; MEDICAL LITERATURE; PRIORITY JOURNAL; RISK FACTOR; TORSADE DES POINTES;

EID: 33751006984     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinte.166.20.2288-b     Document Type: Letter

References (5)

1. Ehret GB, Voide C, Gex-Fabry M, et al. Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors. Arch Intern Med. 2006;166:1280-1287.
2. Piguet V, Desmeules J, Ehret G, Stoller R, Dayer P. QT interval prolongation in patients on methadone with concomitant drugs. J Clin Psychopharmacol. 2004;24:446-448.
3. Pearson EC, Woosley RL. QT prolongation and torsades de pointes among methadone users: reports to the FDA spontaneous reporting system. Pharmacoepidemiol Drug Saf. 2005;14:747-753.
4. Yoshida H, Sugiyama A, Satoh Y, et al. Comparison of the in vivo electrophysiological and proarrhythmic effects of amiodarone with those of a selective class III drug, sematilide, using a canine chronic atrioventricular block model. Circ J. 2002;66:758-762.
5. Justo D, Gal-Oz A, Paran Y, Goldin Y, Zeltser D. Methadone-associated Torsades de Pointes (polymorphic ventricular tachycardia) in opioid-dependent patients. Addiction. 2006;101:1333-1338.