New therapies in the prevention of preeclampsia

Current Opinion in Obstetrics and Gynecology

Volumn 18, Issue 6, 2006, Pages 601-604

  Spinnato II, Joseph A ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Antioxidants; Calcium; Preeclampsia; Prevention

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CALCIUM; PLACEBO;

ACIDOSIS; CALCIUM DEFICIENCY; CALCIUM INTAKE; CLINICAL TRIAL; DEVELOPING COUNTRY; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG FATALITY; DRUG POTENTIATION; HIGH RISK POPULATION; HUMAN; INTERVENTION STUDY; LOW BIRTH WEIGHT; MATERNAL MORTALITY; NEWBORN DISEASE; PATIENT COMPLIANCE; PERINATAL MORTALITY; PREECLAMPSIA; PRIORITY JOURNAL; REVIEW; SAFETY; SMALL FOR DATE INFANT; STILLBIRTH; TREATMENT OUTCOME; VITAMIN SUPPLEMENTATION; WORLD HEALTH ORGANIZATION;

ANTIOXIDANTS; ASCORBIC ACID; CALCIUM; FEMALE; HUMANS; PRE-ECLAMPSIA; PREGNANCY; RANDOMIZED CONTROLLED TRIALS; VITAMIN E;

EID: 33750983938     PISSN: 1040872X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.gco.0000247393.86968.e6     Document Type: Review

References (12)

1. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of preeclampsia in women at increased risk: a randomised trial. Lancet 1999; 354:810-816.
2. Beazley D, Ahokas R, Livingston J, et al. Vitamin C and E supplementation in women at high risk for preeclampsia: a double-blind, placebo-controlled trial. Am J Obstet Gynecol 2005; 192:520-521.
3. Spinnato JA, Livingston JC. Prevention of preeclampsia with antioxidants: evidence from randomized trials. Clin Obstet Gynecol 2005; 48:416-429.
4. Rumbold AR, Crowther CA, Haslam RR, et al., ACTS Study Group. Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med 2006; 354:1796-1806. This large randomization of low risk nulliparous women failed to demonstrate a benefit of vitamins C/E and suggested potential adverse effects of supplementation.
5. Jeyabalan A, Caritis SN. Antioxidants and the prevention of preeclampsia - unresolved issues. N Engl J Med 2006; 354:1841-1843.
6. Poston L, Briley AL, Seed PT, et al., Vitamins in Preeclampsia (VIP) Trial Consortium. Vitamin C and vitamin E in pregnant women at risk for preeclampsia (VIP trial): randomised placebo-controlled trial. Lancet 2006; 367:1145-1154. This large prospective randomization of patients at increased risk for preeclampsia failed to demonstrate a benefit of vitamins C/E and suggested potential adverse effects of supplementation.
7. Lindheimer MD, Sibai BM. Antioxidant supplementation in preeclampsia. Lancet 2006; 367:1119-1120.
8. Miller ER 3rd, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005; 142:37-46.
9. Fraser WD, Audibert F, Bujold E, et al. The vitamin E debate: implications for ongoing trials of preeclampsia prevention. BJOG 2005; 112:684-688.
10. Banerjee S, Chambers AE, Campbell S. Is vitamin E a safe prophylaxis for preeclampsia? Am J Obstet Gynecol 2006; 194:1228-1233. This paper puts forward hypotheses that immunologic changes induced by vitamin E may have undesirable consequences for pregnancy.
11. Romero R, Garite TJ. Unexpected results of an important trial of vitamins C and E administration to prevent preeclampsia. Am J Obstet Gynecol 2006; 194:1213-1214.
12. Villar J, Abdel-Aleem H, Merialdi M, et al. World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women. Am J Obstet Gynecol 2006; 194:639-649. This large randomization of patients in geographic areas where diets are deficient in calcium failed to reduce the incidence of preeclampsia or low birthweight.