Effects of Korean red ginseng on the vaginal blood flow and structure in female castrated rats

Korean Journal of Urology

Volumn 47, Issue 8, 2006, Pages 888-894

  Kim, Sun Ouck ^a   Lee, Mina ^a   Xui, Y ^b   Ahn, Kyu Youn ^a   Hong, Hee Do ^c   Kim, Sung Soo ^c   Park, Kwangsung ^a  

^a Chonnam National University Medical School   (South Korea)

^b MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^c Korea Food Research Institute   (South Korea)

Author keywords

Ginseng; Menopause; Sexual dysfunction; Vagina

Indexed keywords

CHOLESTEROL; ESTROGEN; ESTROGEN RECEPTOR; GINSENG EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASTRATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFICACY; ESTROGEN BLOOD LEVEL; FEMALE; FEMALE SEXUAL DYSFUNCTION; HISTOPATHOLOGY; HORMONE DETERMINATION; IMMUNOHISTOCHEMISTRY; LASER DOPPLER FLOWMETRY; MENOPAUSE; MICROVASCULATURE; NERVE STIMULATION; NONHUMAN; ORGAN BLOOD FLOW; PELVIC NERVE; PROTEIN EXPRESSION; RAT; RAT STRAIN; SUBMUCOSA; TISSUE STRUCTURE; TREATMENT DURATION; VAGINA EPITHELIUM; WESTERN BLOTTING;

EID: 33750982380     PISSN: 04944747     EISSN: None     Source Type: Journal    
DOI: 10.4111/kju.2006.47.8.888     Document Type: Article

References (28)

1. Goldstein MK, Teng NN. Gynecologic factors in sexual dysfunction of the older woman. Clin Geriatr Med 1991;7:41-61
2. Sadeghi-Nejad H, Moreland RB, Traish AM, Nehra A, Azadzoi KM, Goldstein I. Preliminary report on the development and characterization of rabbit clitoral smooth muscle cell culture. Int J Impot Res 1998;10:165-9
3. Sarrel PM. Sexual dysfunction: treat or refer. Obstet Gynecol 2005;106:834-9
4. Sarrel PM. Ovarian hormones and vaginal blood flow: using laser Doppler velocimetry to measure effects in a clinical trial of post-menopausal women. Int J Impot Res 1998;10(Suppl 2):S91-3
5. Park K, Goldstein I, Andry C, Siroky MB, Krane RJ, Azadzoi KM. Vasculogenic female sexual dysfunction: the hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency. Int J Impot Res 1997;9:27-37
6. Tarcan T, Park K, Goldstein I, Maio G, Fassina A, Krane RJ, et al. Histomorphometric analysis of age-related structural changes in human clitoral cavernosal tissue. J Urol 1999; 161:940-4
7. Woo J, Lau E, Ho SC, Cheng F, Chan C, Chan AS, et al. Comparison of Pueraria lobata with hormone replacement therapy in treating the adverse health consequences of menopause. Menopause 2003;10:352-61
8. Choi YD, Rha KH, Choi HK. In vitro and in vivo experimental effect of Korean red ginseng on erection. J Urol 1999;162:1508-11
9. Jung HC, Yu JW, Park JM, Shin HS, Moon KH, Kim WJ, et al. Effect of ginseng on penile erection: a combined in vitro and in vivo study. Korean J Androl 2001;19:57-61
10. Kim SW, Paick JS. Clinical efficacy of Korea red ginseng on vasculogenic impotent patients. Korean J Androl 1999;17:23-8
11. Jung HC, Suh JK. Effect of total saponin on penile erection: a combined in vitro and in vivo study. Korean J Urol 1997; 38:866-72
12. Cho J, Park W, Lee S, Ahn W, Lee Y. Ginsenoside-Rb1 from Panax ginseng C.A. Meyer activates estrogen receptor-alpha and -beta, independent of ligand binding. J Clin Endocrinol Metab 2004;89:3510-5
13. Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 2002;137:805-13
14. Duda RB, Zhong YZ, Navas V, Li MZ, Toy BR, Alavarez JG. American ginseng and breast cancer therapeutic agents synergistically inhibit MCF-7 breast cancer cell growth. J Surg Oncol 1999;72:230-9
15. Chan RY, Chen WF, Dong A, Guo D, Wong MS. Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng. J Clin Endocrinol Metab 2002;87:3691-5
16. Lee Y, Jin Y, Lim W, Ji S, Choi S, Jang S, et al. A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol Biol 2003;84:463-8
17. Chen X, Gillis CN, Moalli R. Vascular effects of ginsenosides in vitro. Br J Pharmacol 1984;82:485-91
18. Kang SY, Schini-Kerth VB, Kim ND. Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta. Life Sci 1995;56:1577-86
19. Chen X, Lee TJ. Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br J Pharmacol 1995;115:15-8
20. Choi YD, Xin ZC, Choi HK. Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle. Int J Impot Res 1998;10:37-43
21. Hong B, Ji YH, Hong JH, Nam KY, Ahn TY. A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002;168:2070-3
22. Park KS, Kim GS, Kim SO, Kim DS, Kim MK, Park JK, et al. Effects of ginsenosides on relaxation of rabbit vaginal smooth muscle. Korean J Androl 2003;21:98-102
23. Kang HJ, Ansbacher R, Hammoud MM. Use of alternative and complementary medicine in menopause. Int J Gynaecol Obstet 2002;79:195-207
24. Huntley AL, Ernst E. A systematic review of herbal medicinal products for the treatment of menopausal symptoms. Menopause 2003;10:465-76
25. Park KS, Ryu SB, Park YI, Ahn KY. Effects of estrogen deprivation on the rabbit clitoral cavernosal fibrosis. Korean J Urol 2001;41:885-91
26. Teki T. "The clinical effects of korean ginseng, a clinical experimental study" 1st ed. Seoul: Korea Ginseng and Tobacco Research Institute; 1993;157-63
27. Grodin JM, Siiteri PK, MacDonald PC. Source of estrogen production in postmenopausal women. J Clin Endocrinol Metab 1973;36:207-14
28. Azadzoi KM, Krane RJ, Saenz de Tejada I, Goldstein I, Siroky MB. Relative roles of cyclooxygenase and nitric oxide synthase pathways in ischemia-induced increased contraction of cavernosal smooth muscle. J Urol 1999;161:1324-8