No significant difference between intact and testosterone depleted or administrated male rats in spatial learning and memory

Iranian Journal of Pharmaceutical Research

Volumn 4, Issue 1, 2005, Pages 29-32

  Naghdi, Nasser ^a   Mohaddess, Gisso ^b   Khamnei, Saeid ^b   Arjomand, Mohammad ^a  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Castration; Morris water maze; Rat; RIA; Spatial memory

Indexed keywords

EID: 33750972437     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: 10.22037/IJPR.2010.613     Document Type: Article

References (20)

1. Kimoto T, Tsurugizawa T, Ohta Y, Makino J, Tamura H, Hojo Y, Takata N and Kawato S. Neurosteroid synthesis by cytochrome P450-containing systems localized in the rat brain hippocampal neurons:NMethyl –D-Aspartate and calcium-dependent synthesis. Endocrinology (2001) 142: 3578-3589
2. Nakamura N, Fujita H and Kawata M. Effects of gonadectomy on immunoreactivity for choline acetyltransferase in the cortex, hippocampus, and basal forebrain of adult male rats. Neuroscience. (2002) 109: 473-485
3. Janowsky JS, Oviatt SK and Orwoll ES. Testosterone influences spatial cognition in older men. Behav. Neurosci. (1994) 108: 325-332
4. Frye CA and Sturgis JD. Neurosteroids affect spatial/ reference, working and long-term memory of female rats. Neurobiology of Learning and Memory (1995) 64: 83-96
5. Frye CA, Edinger KL, Selige AM and Wawrzycki JM. 5α−reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats. Psychoneuroendocrinology (2004) 29: 1019-1027
6. Hampson E. Spatial cognition in humans: possible modulation by androgens and estrogens. J. Psychol. Neurosci. (1995) 20: 397-404
7. Goudsmith E, Van de Poll NE, Swaab DF. Testosterone fails to reverse spatial memory decline in aged rats and impairs retention in young and middle-aged animals. Behavioral & Neural Bio. (1990) 53: 6-20
8. Tan RS. Memory loss as a reported symptom of andropause. Arch. Andrology (2001) 47:185-189
9. Dawson JLM, Cheung YM and Lau RTS. Developmental effects of neonatal sex hormones on spatial and activity skills in the white rat. Biol. Psychol. (1975) 3: 213-229
10. Naghdi N, Nafisy N and Majlessi N. The effects of intrahippocampal testosterone and flutamide on spatial localization in the Morris water maze. Brain Res. (2001) 897: 44-51
11. Wehling M. Specific, non-genomic actions of steroid hormones. Annu. Rev. Physiol. (1997) 59: 365-393
12. Alexander GM, Packard MG and Hines M. Testosterone has rewarding affective properties in male rats: implications for the biological basis of sexual motivation. Behav. Neurosci.(1994)108: 424-428
13. Flood JF and Roberts E. Dihydroepiandrosterone sulfate improves memory in aging mice. Brain Res. (1988) 118: 178-181
14. Vazquez-Pereyra F, Rivas-Arancibia S, Castillo ALD. Modulation of short-term and long-term memory by steroid sexual hormones. Life Sci. (1995) 56: 255-260
15. Galea LA, Kavaliers M, Ossenkopp KP and Hampson E. Gonadal hormone levels and spatial learning performance in the Morris water maze in male and female meadow voles, Microtus pennsylvanicus, Horm. Behav. (1995) 29: 106-125
16. Gouchie C and Kimura D. The relationship between testosterone levels and cognitive ability patterns. Psychoneuroendocrinology (1991)16: 323-334
17. Kampen DL and Sherwin BB. Estradiol related to visual memory in healthy young men. Behav. Neurosci. (1996) 110: 613-617
18. Smith ST, Stackman RW, Clark AS. Spatial working memory is preserved in rats treated with anabolicandrogenic steroids. Brain Res. (1996) 737: 313-316
19. Barret-Connor E,Goodman-Gruen D and Patay B. Endogenous sex hormones and cognitive function in older men. Clinical Endocrinology and metabolism (1999) 48: 3681-3685
20. Wolf PT and Kirschbaum C. Endogenous estradiol and testosterone levels are associated with cognitive performance in older women and men. Hormones and Behavior (2002) 41: 259-266