Antibodies against synthetic epitopes inhibit the enzymatic activity of mutalysin II, a metalloproteinase from bushmaster snake venom

Toxicon

Volumn 48, Issue 8, 2006, Pages 1098-1103

  Ferreira, R N ^a   Machado de Avila, R A ^a   Sanchez, E F ^b   Maria, W S ^b   Molina, F ^c   Granier, C ^c   Chavez Olortegui C ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FUNDAÇÃO EZEQUIEL DIAS   (Brazil)

^c Centre de Pharmacologie et Biotechnologie Pour la Santé   (France)

Author keywords

Lachesis muta muta; Metalloproteinase; Mutalysin II; Snake venoms; Synthetic epitopes

Indexed keywords

AMINO ACID; ANTIBODY; CROSS REACTING ANTIBODY; EPITOPE; FIBRINOGEN; HEMOCYANIN; IMMUNOGLOBULIN G; METALLOPROTEINASE; MONOCLONAL ANTIBODY; MUTALYSIN II; PEPTIDE ANTIBODY; POLYCLONAL ANTIBODY; SNAKE VENOM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIGEN BINDING; ARTICLE; BLEEDING; CARBOXY TERMINAL SEQUENCE; CROSS REACTION; ENZYME ACTIVITY; EVOLUTIONARY HOMOLOGY; FEMALE; FRAMESHIFT MUTATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RABBIT;

ANIMALS; ANTIVENINS; EPITOPES; FEMALE; IMMUNOGLOBULIN G; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; RABBITS; VIPER VENOMS;

BOTHROPS; LACHESIS MUTA MUTA; ORYCTOLAGUS CUNICULUS;

EID: 33750952272     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2006.07.040     Document Type: Article

References (16)

1. Alvarenga L.M., Diniz C.R., Granier C., and Chávéz-Olórtegui C. Induction of neutralizing antibodies against Tityus serrulatus scorpions toxins by immunization with a mixture of defined synthetic epitopes. Toxicon 40 (2002) 89-95
2. Bjarnason J.B., and Fox J.W. Hemorrhagic metalloproteinases from snake venoms. Pharmacol. Ther. 62 (1994) 325-372
3. Chavez-Olortegui C., Amara D.A., Rochat H., Diniz C., and Granier C. In vivo protection against scorpion toxins by liposomal immunization. Vaccine 9 12 (1991) 907-910
4. Estevão-Costa M.I., Martins M.S., Sanchez E.F., Diniz C.R., and Chavez-Olortegui C. Neutralization of the hemorrhagic activity of Bothrops and Lachesis snake venoms by a monoclonal antibody against mutalysin II. Toxicon 38 (2000) 139-144
5. Estevão-Costa M.I., Diniz C.R., Magalhaes A., Markland F.S., and Sanchez E.F. Action of metalloproteinases mutalysin I and II on several components of the hemostatic and fibrinolytic systems. Thromb. Res. 99 (2000) 363-376
6. Ey P.L., Powse S.J., and Jenkin C.R. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose. Immunochemistry 15 (1978) 429-436
7. Frank R. Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron 48 (1992) 9217-9232
8. Gomis-Ruth F.X., Kress L.F., Kellermann J., Mayr I., Lee X., Huber R., and Bode W. Refined 2 Å X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin. J. Mol. Biol. 239 (1994) 513-544
9. Laune D., Molina F., Ferrieres G., Villard S., Bes C., Rieunier F., Chardes T., and Granier C. Application of the Spot method to the identification of peptides and amino acids from the antibody paratope that contribute to antigen binding. J. Immunol. Meth. 267 (2002) 53-70
10. Rucavado A., Sanchez E.F., Franceschi A., Magalhães A., and Gutiérrez J.M. Characterization of the local tissue damage induced by LHFII, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom. Toxicon 37 (1999) 1297-1312
11. Sali A., and Blundell T.L. Comparative protein modeling by satisfaction of spacial restraints. J. Mol. Biol. 234 (1993) 779-815
12. Sanchez E.F. Mutalysins. In: Barrett A.J., Rawlings N.D., and Woessner J.F. (Eds). Handbook of Proteolytic Enzymes (2004), Elsevier Ltd, Amsterdam 692-694 (Chapter 198)
13. Sanchez E.F., Magalhães A., Mandelbaum F.R., and Diniz C.R. Purification and characterization of the hemorrhagic factor I from the venom of the bushmaster snake (Lachesis muta muta). Biochim. Biophys. Acta 1074 (1991) 347-354
14. Sanchez E.F., Diniz C.R., and Richardson M. The complete amino acid sequence of the haemorrhagic factor LHFII, a metalloproteinase isolated from the venom of the bushmaster snake (Lachesis muta muta). FEBS Lett. 282 (1991) 178-182
15. Souza C.T., Moura M.B., Magalhães A., Heneine L.G.D., Chavez-Olortegui C., Diniz C.R., and Sanchez E.F. Inhibition of mutalisyn II, a metalloproteinase from bushmaster snake venom by human α 2-macroglobulin and rabbit immunoglobulin. Comp. Biochem. Physiol. Part B 130 (2001) 155-168
16. Stocker W., Grams F., Baumann U., Reinemer P., Franz-Xaver G., Mckay D.B., and Bode W. The metzincins-topological and sequential relations between astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases. Protein Sci. 4 (1995) 823-840