Not all eicosanoids are bad

Trends in Pharmacological Sciences

Volumn 27, Issue 12, 2006, Pages 609-611

  Morris, Thea ^a   Rajakariar, Ravindra ^b   Stables, Melanie ^a   Gilroy, Derek W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CYSTEINE; CYTOCHROME P450 1A1; CYTOKINE; GAMMA INTERFERON; ICOSANOID; INTERLEUKIN 12; LEUKOTRIENE B4; LIPOXIN; LIPOXIN A; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; SUPPRESSOR OF CYTOKINE SIGNALING 2;

ENZYME SYNTHESIS; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; HOST RESISTANCE; INFECTION; INFLAMMATION; NONHUMAN; PARASITE; POLLUTION; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOXINS; PARASITIC DISEASES;

EID: 33750942661     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2006.10.001     Document Type: Short Survey

References (20)

1. Chiang N., et al. Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX. Prostaglandins Leukot. Essent. Fatty Acids 73 (2005) 163-177
2. Serhan C.N., and Savill J. Resolution of inflammation: the beginning programs the end. Nat. Immunol. 6 (2005) 1191-1197
3. 4 and aspirin-triggered lipoxin are SOCS-2 dependent. Nat. Med. 12 (2006) 330-334
4. Aliberti J., et al. Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. Nat. Immunol. 3 (2002) 76-82
5. Claria J., and Serhan C.N. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 9475-9479
6. Samuelsson B. From studies of biochemical mechanism to novel biological mediators: prostaglandin endoperoxides, thromboxanes, and leukotrienes. Nobel Lecture, 8 December 1982. Biosci. Rep. 3 (1983) 791-813
7. Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol. 231 (1971) 232-235
8. Williams K.I., and Higgs G.A. Eicosanoids and inflammation. J. Pathol. 156 (1988) 101-110
9. 2 in the induction of nonspecific T lymphocyte suppressor activity. J. Immunol. 126 (1981) 1452-1455
10. 2 as a mediator of allergic asthma. Science 287 (2000) 2013-2017
11. 2 synthase in the control of delayed type hypersensitivity. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 5179-5184
12. Ford-Hutchinson A.W., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286 (1980) 264-265
13. 4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. J. Exp. Med. 196 (2002) 1253-1262
14. 4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation. J. Exp. Med. 200 (2004) 69-78
15. Denison M.S., et al. Ligand binding and activation of the Ah receptor. Chem. Biol. Interact. 141 (2002) 3-24
16. 4: a new class of ligand for the Ah receptor. Biochemistry 38 (1999) 7594-7600
17. Poland A., and Knutson J.C. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22 (1982) 517-554
18. Elliott D.E., et al. Does the failure to acquire helminthic parasites predispose to Crohn's disease?. FASEB J. 14 (2000) 1848-1855
19. 4 biosynthesis. J. Exp. Med. 199 (2004) 515-523
20. Kurzrok R., and Lieb C.C. Biochemical studies of human semen. II. The action of semen on the human uterus. Proc. Soc. Exp. Biol. Med. 28 (1930) 268-272