Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope

Arthritis and Rheumatism

Volumn 54, Issue 11, 2006, Pages 3423-3432

  Ling, Song ^a   Lai, Angela ^a   Borschukova, Olga ^b   Pumpens, Paul ^b   Holoshitz, Joseph ^a,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF LATVIA   (Latvia)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 NAPHTHALENEDIAMINE; 4,5 DIAMINOFLUORESCEIN DIACETATE; ARGININE; CITRULLINE; CORE PROTEIN; CYCLIC GMP; EPITOPE; FLUORESCENT DYE; HLA DR ANTIGEN; NITRIC OXIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CHROMIUM 51 RELEASE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GENETIC SUSCEPTIBILITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; LYMPHOBLASTOID CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES; CELL LINE; CHROMIUM RADIOISOTOPES; EPITOPES, B-LYMPHOCYTE; FIBROBLASTS; FLUORESCEIN; HLA-DR1 ANTIGEN; HUMANS; INDICATORS AND REAGENTS; MOLECULAR SEQUENCE DATA; NITRIC OXIDE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 33750932400     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.22178     Document Type: Article

References (50)

1. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205-13.
2. Wucherpfennig KW, Strominger JL. Selective binding of self peptides to disease-associated major histocompatibility complex (MHC) molecules: a mechanism for MHC-linked susceptibility to human autoimmune diseases. J Exp Med 1995;181:1597-601.
3. La Cava A, Nelson JL, Ollier WE, MacGregor A, Keystone EC, Thorne JC, et al. Genetic bias in immune responses to a cassette shared by different microorganisms in patients with rheumatoid arthritis. J Clin Invest 1997;100:658-63.
4. Bhayani HR, Hedrick SM. The role of polymorphic amino acids of the MHC molecule in the selection of the T cell repertoire. J Immunol 1991;146:1093-8.
5. Weyand CM, Hunder NN, Hicok KC, Hunder GG, Goronzy JJ. HLA-DRB1 alleles in polymyalgia rheumatica, giant cell arteritis, and rheumatoid arthritis. Arthritis Rheum 1994;37:514-20.
6. Doherty DG, Donaldson PT, Underhill JA, Farrant JM, Duthie A, Meili-Vergani G, et al. Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis. Hepatology 1994;19:609-15.
7. Korendowych E, Dixey J, Cox B, Jones S, McHugh N. The influence of the HLA-DRB1 rheumatoid arthritis shared epitope on the clinical characteristics and radiological outcome of psoriatic arthritis. J Rheumatol 2003;30:96-101.
8. Dorak MT, Machulla HK, Hentschel M, Mills KI, Langner J, Burnett AK. Influence of the major histocompatibility complex on age at onset of chronic lymphoid leukaemia. Int J Cancer 1996;65:134-9.
9. Ollier WE, Kennedy LJ, Thomson W, Barnes AN, Bell SC, Bennett D, et al. Dog MHC alleles containing the human RA shared epitope confer susceptibility to canine rheumatoid arthritis. Immunogenetics 2001;53:669-73.
10. Rosloniec EF, Brand DD, Myers LK, Whittington KB, Gumanovskaya M, Zaller DM, et al. An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen. J Exp Med 1997;185:1113-22.
11. Forsthuber TG, Shive CL, Wienhold W, de Graaf K, Spack EG, Sublett R, et al. T cell epitopes of human myelin oligodendrocyte glycoprotein identified in HLA-DR4 (DRB1*0401.) transgenic mice are encephalitogenic and are presented by human B cells. J Immunol 2001;167:7119-25.
12. Bogdan C. Nitric oxide and the immune response. Nat Immunol 2001;2:907-16.
13. Stichtenoth DO, Frolich JC. Nitric oxide and inflammatory joint diseases. Br J Rheumatol 1998;37:246-57.
14. Yki-Jarvinen H, Bergholm R, Leirisalo-Repo M. Increased inflammatory activity parallels increased basal nitric oxide production and blunted response to nitric oxide in vivo in rheumatoid arthritis. Ann Rheum Dis 2003;62:630-4.
15. Wang B, Ma L, Tao X, Lipsky PE. Triptolide. an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription. Arthritis Rheum 2004;50:2995-3003.
16. Grant DD, Goldstein R, Karsh J, Birnboim HC. Nitric oxide donors induce large-scale deletion mutations in human lympho-blastoid cells: implications for mutations in T-lymphocytes from arthritis patients. Environ Mol Mutagen 2001;38:261-7.
17. Tamir S, de Rojas-Walker T, Gal A, Weller AH, Li X, Fox JG, et al. Nitric oxide production in relation to spontaneous B-cell lymphoma and myositis in SJL mice. Cancer Res 1995;55:4391-7.
18. Compton SA, Elmore LW, Haydu K, Jackson-Cook CK, Holt SE. Induction of nitric oxide synthase-dependent telomere shortening after functional inhibition of Hsp90 in human tumor cells. Mol Cell Biol 2006;26:1452-62.
19. - mutant T cells in the peripheral blood and synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 1998;41:1772-82.
20. Yamanishi Y, Boyle DL, Green DR, Keystone EC, Connor A, Zollman S, et al. p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis. Arthritis Res Ther 2005;7: R12-8.
21. Baecklund E, Iliadou A, Askling J, Ekbom A, Backlin C, Granath F, et al. Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum 2006;54:692-701.
22. Schonland SO, Lopez C, Widmann T, Zimmer J, Bryl E, Goronzy JJ, et al. Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages. Proc Natl Acad Sci U S A 2003;100:13471-6.
23. Olson RR, Reuter JJ, McNicholl J, Alber C, Klone E, Callahan K, et al. Acidic residues in the DR β chain third hypervariable region are required for stimulation of a DR(α, β 1*0402)-restricted T-cell clone. Hum Immunol 1994;41:193-200.
24. Holoshitz J, Vila LM, Keroack BJ, McKinley DR, Bayne NK. Dual antigenic recognition by cloned human γδ T cells. J Clin Invest 1992;89:308-14.
25. Koizumi H, Liu CC, Zheng LM, Joag SV, Bayne NK, Holoshitz J, et al. Expression of perform and serine esterases by human γ/δ T cells. J Exp Med 1991;173:499-502.
26. Day CL, Seth NP, Lucas M, Appel H, Guathier L, Lauer GM, et al. Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J Clin Invest 2003;112:831-42.
27. Pumpens P, Grens E. Hepatitis B core particles as a universal display model: a structure-function basis for development. FEBS Lett 1999;442:1-6.
28. Borisova G, Borschukova O, Skrastina D, Dislers A, Ose V, Pumpens P, et al. Behavior of a short preS1 epitope on the surface of hepatitis B core particles. Biol Chem 1999;380:315-24.
29. Bronte V, Serafina P, De Santo C, Marigo I, Tosello V, Mazzoni A, et al. IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice. J Immunol 2003;170:270-8.
30. Hegardt P, Widegren B, Sjogren HO. Nitric-oxide-dependent systemic immunosuppression in animals with progressively growing malignant gliomas. Cell Immunol 2000;200:116-27.
31. Pope RM. Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat Rev Immunol 2002;2:527-35.
32. Mountz JD, Hsu HC, Matsuki Y, Zhang HG. Apoptosis and rheumatoid arthritis: past, present and future directions. Curr Rheum Rep 2001;3:70-8.
33. Carding SR, Egan PJ. γδ T cells: functional plasticity and heterogeneity. Nat Rev Immunol 2002;2:336-44.
34. Bank I, Cohen L, Mouallem M, Farfel Z, Grossman E, Ben-Nun A. γδ T cell subsets in patients with arthritis and chronic neutropenia. Ann Rheum Dis 2002;61:438-43.
35. Holoshitz J. Activation of γδ T cells by mycobacterial antigens in rheumatoid arthritis. Microbes Infect 1999;1:197-202.
36. Hajeer AH, Worthington J, Silman AJ, Ollier WE. Association of tumor necrosis factor microsatellite polymorphisms with HLA-DRB1*04-bearing haplotypes in rheumatoid arthritis patients. Arthritis Rheum 1996;39:1109-14.
37. Bodinier M, Peyrat MA, Tournay C, Davodeau F, Romagne F, Bonneville M, et al. Efficient detection and immunomagnetic sorting of specific T cells using multimers of MHC class I and peptide with reduced CD8 binding. Nat Med 2000;6:707-10.
38. Boytim ML, Lyu SC, Jung R, Krensky AM, Clayberger C. Inhibition of cell cycle progression by a synthetic peptide corresponding to residues 65-79 of an HLA class II sequence: functional similarities but mechanistic differences with the immunosuppressive drug rapamycin. J Immunol 1998;160:2215-22.
39. Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, et al. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993;364:33-9.
40. Gleimer M, Parham P. Stress management: MHC class I and class I-like molecules as reporters of cellular stress. Immunity 2003;19:469-77.
41. Brooks AG, Boyington JC, Sun PD. Natural killer cell recognition of HLA class I molecules. Rev Immunogenetics 2000;2:433-48.
42. Bennett MJ, Lebron JA, Bjorkman PJ. Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor. Nature 2000;403:46-53.
43. Loconto J, Papes F, Chang E, Stowers L, Jones EP, Takada T, et al. Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules. Cell 2003;112:607-18.
44. Klareskog L, Stolt P, Lundberg K, Kallberg H, Bengtsson C, Grunewald J, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006;54:38-46.
45. Silman AJ, MacGregor AJ. Thomson W, Holligan S, Carthy D, Farhan A, et al. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br J Rheumatol 1993;32:903-7.
46. Hmadcha A, Bedoya FJ, Sobrino F, Pintado E. Methylation-dependent gene silencing induced by interleukin 1β via nitric oxide production. J Exp Med 1999;190:1595-604.
47. Wachsman JT. DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis. Mutat Res 1997;375:1-8.
48. Fulop T Jr, Larbi A, Dupuis G, Pawelec G. Ageing, autoimmunity and arthritis: perturbations of TCR signal transduction pathways with ageing: a biochemical paradigm for the ageing immune system. Arthritis Res Ther 2003;5:290-302.
49. Gorman JD, Lum RF, Chen JJ, Suarez-Almazor ME, Thomson G, Criswell LA. Impact of shared epitope genotype and ethnicity on erosive disease: a meta-analysis of 3,240 rheumatoid arthritis patients. Arthritis Rheum 2004;50:400-12.
50. Van der Helm-van Mil AH, Huizinga TW, Schreuder GM, Breedveld FC, de Vries RR, Toes RE. An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility. Arthritis Rheum 2005;52:2637-44.