Possible mechanism for testicular focal necrosis induced by hCG in rats

Journal of Toxicological Sciences

Volumn 31, Issue 4, 2006, Pages 291-303

  Chatani, Fumio ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Blood flow; hCG; Necrosis; Prostaglandin; Rat; Testis

Indexed keywords

CHORIONIC GONADOTROPIN; CYCLOOXYGENASE 2 INHIBITOR; DOCEBENONE; ETHYLENE GLYCOL DIMESYLATE; INDOMETACIN; ISBOGREL; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; SERATRODAST; THROMBOXANE SYNTHASE INHIBITOR;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ISCHEMIA; LASER DOPPLER FLOWMETRY; LEYDIG CELL; LEYDIG CELL TUMOR; MALE; NECROSIS; NONHUMAN; PROSTAGLANDIN SYNTHESIS; RAT; TESTIS BLOOD FLOW; TESTIS DISEASE;

EID: 33750926473     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.31.291     Document Type: Article

References (15)

1. Ashida, Y., Saijo, T., Kuriki, H., Makino, H., Terao, S. and Maki, Y. (1983): Pharmacological profile of AA-861, a 5-lipoxygenase inhibitor, Prostaglandins, 26, 955-972.
2. Chan, C.-C., Boyce, S., Brideau, S., Charleson, W., Cromlish, D., Ethier, D., Evams, J., Ford-Hutchinson, M.J., Forrest, J.Y., Gauthier, J.Y., Gordon, R., Gresser, M., Guay, J., Kargman, S., Kennedy, B., Leblanc, Y., Leger, S., Mancini, J., O'Neill, G.P., Ouellet, M., Patrick, D., Percival, M.D., Perrier, H., Prasit, P., Rodger, I., Tagari, P., Therien, M., Vickers, P., Visco, D., Wang, Z., Webb, J., Wong, E., Xu, L.-J., Young, R.N., Zamboni, R. and Riendeau, D. (1999): Rofexob [Vioxx, MK-0966; 4-(4′-methylsulfonylphenyl)-3-phenyl- 2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J. Pharmacol. Exp. Ther., 290, 551-560.
3. Chatani, F., Nonoyama, T., Sudo, K., Miyajima, H., Takeyama, M., Takatsuka, D., Mori, H. and Matsumoto, K. (1990): Stimulatory effect of luteinizing hormone on the development and maintenance of 5α-reduced steroid-producing testicular interstitial cell tumors in Fischer 344 rats. Anticancer Res., 10, 337-342.
4. Chatani, F. (1996): Testicular necrosis induced by hCG in rats - time-course and age- and strain differences - J. Toxicol. Pathol., 9, 369-379.
5. Goodman, D.G., Ward, J.M., Squire, R.A., Chu, K.C. and Linhart, M.S. (1979): Neoplastic and non-neoplastic lesions in aging F344 rats. Toxicol. Appl. Pharmacol., 48, 237-248.
6. 2α release in adult rat testis: Role in Leydig cell desensitization to hCG. Life Sci., 24, 2151-2158.
7. Haour, F., Dray, F. and Mather, J.P. (1982) : In vivo and in vitro response of Leydig cells to acute stimulation by hCG. Ann. N.Y. Acad. Sci., 383, 231-248.
8. 2 synthetase inhibitor. Eur. J. Pharmacol., 147, 359-365.
9. 2/ prostaglandin endoperoxide receptor in platelets and blood vessels. Jpn. J. Pharmacol., 52, 35-43.
10. Morris, I.D., Phillips, D.M. and Bardin, C.W. (1987): Ethylene dimethanesulphonate destroys Leydig cells in the rat testis. Endocrinology, 118, 709-719.
11. Oettlé, A.G. and Harrison, R.G. (1950): The histological changes produced in the rat testis by temporary and permanent occulusion of the testicular artery. J. Path. Bact., 64, 273-297.
12. 2α on androgen production of adult rat testis in vivo. Prostagl. Lipid Mediat., 55, 121-126.
13. Setchell, B.P. (1970): Testicular blood supply, lymphatic drainage, and secretion of fluid. In The Testis (Johnson, A.D., Gomes, W.R. and Vandemark, N.L., eds.), vol. 1, p120, Academic Press.
14. van Vliet, J., Rommerts, F.F.G., de Rooij, D.G., Buwalda, G. and Wensing, C.J.G. (1988): Reduction of testicular blood flow and focal degeneration of tissue in the rat after administration of human chorionic gonadotrophin. J. Endocr., 117, 51-57.
15. Widmark, A., Damber, J.-E. and Bergh, A. (1986): Relationship between human chorionic gonadotrophin-induced changes in testicular microcirculation and the formation of testicular interstitial fluid. J. Endocr., 109, 419-425.