Determination of zolmitriptan in human plasma by HPLC-MS and study on bioequivalence of domestic and import zolmitriptan tablets

Chinese Pharmaceutical Journal

Volumn 41, Issue 19, 2006, Pages 1488-1490

  Ding, Jin Song ^a   Zhu, Rong Hua ^b   Zhu, Yun Gui ^b   Li, Huan De ^b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

HPLC MS; Relative bioavailability; Solid phase extraction; Zolmitriptan

Indexed keywords

ZOLMITRIPTAN;

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; STANDARD; TABLET FORMULATION;

EID: 33750915825     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. CLEMENT E M, FRANKLIN M. Simultaneous measurement of zolmitriptan and its major metabolites N-desmethylzolmitriptan and zolmitriptan N-oxide in human plasma by high-performance liquid chromatography with coulometric detection[J]. J Chromatogr B, 2002, 766(2):339-343.
2. YATES R A, TATENO M, NAIRN K, et al. The pharmacokinetics of the antimigraine compound zolmitriptan in Japanese and Caucasian subjects [J]. Eur J Clin Phamacol, 2002, 58(4):247-252.
3. DIXON R, FRENCH S, KEMP J, et al. The metabolism of zolmitriptan:the effects of an inducer and an inhibitor on cytochrome P450 on its pharmacokinetics in healthy volunteers[J]. Clin Drug Invest, 1998, 15:515-522.
4. DIXON R, CILLOTIN C, GIBBENSM, et al. The pharmacokinetics and effects on blood pressure of multiple doses of the novel antimigraine drug zolmitriptan(311C90) in healthy volunteers[J]. Eur J Clin Pharmacol, 1997, 43:273-281.