Pharmacokinetics and hepatic extraction of recombinant human parathyroid hormone, hPTH (1-34), in rat, dog, and monkey

Journal of Pharmaceutical Sciences

Volumn 95, Issue 11, 2006, Pages 2499-2506

  Jones, Karen O ^a   Owusu Ababio, Godfried ^a   Vick, Andrew M ^a   Khan, M Amin ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Hepatic extraction; hPTH (1 34); Intraportal vein administration; Peptide delivery; Pharmacokinetics; Saturation

Indexed keywords

RECOMBINANT PARATHYROID HORMONE; RECOMBINANT PARATHYROID HORMONE[1-34]; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE REGIMEN; DRUG HALF LIFE; EXTRACTION; FIRST PASS EFFECT; IMMUNOREACTIVITY; LIVER CIRCULATION; MALE; MAXIMUM ALLOWABLE CONCENTRATION; MONKEY; NONHUMAN; RAT;

EID: 33750905244     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20720     Document Type: Article

References (17)

1. Woodley JF. 1994. Enzymatic barriers for GI peptide and protein delivery. Crit Rev Ther Drug Carrier Sys 11:61-95.
2. Habener JF, Rosenblatt M, Potts JT. 1984. Parathyroid hormone: Biochemical aspects of biosynthesis secretion action and metabolism. Physiol Rev 64:985-1083.
3. Segre GV, D'Amour P, Hultman A, Potts JT. 1981. Effects of hepatectomy, nephrectomy, and nephrectomy/uremia on the metabolism of parathyroid hormone in the rat. J Clin Invest 67:439-448.
4. Segre GV, Perkins A, Witters LA. 1981. Metabolism of parathyroid hormone by isolated rat kupffer cells and hepatocytes. J Clin Invest 67:449-457.
5. Endres DB, Villanueva R, Sharp CF, Singer FR. 1989. Measurement of parathyroid hormone. Hypercalcemia 18:611-629.
6. Bringhurst FR, Segre GV, Lampman GW, Potts JT. 1982. Metabolism of parathyroid hormone by kupffer cells: Analysis by reverse-phase high-performance liquid chromatography. Biochem 21: 4252-4258.
7. Bergeron JJ, Tchervenkov S, Rouleau MF, Rosenblatt M, Goltzman D. 1981. In vivo demonstration of receptors in rat liver to the amino-terminal region of parathyroid hormone. Endocrinology 109:1552-1559.
8. Rouleau MF, Warshawsky H, Goltzman D. 1986. Parathyroid hormone binding in vivo to renal, hepatic, and skeletal tissues of the rat using a radioautographic approach. Endocrinology 118: 919-931.
9. Daugaard H, Egfjord M, Lewin E, Olgaard K. 1994. Metabolism of N-terminal and C-terminal parathyroid hormone fragments by isolated perfused rat kidney and liver. Endocrinology 134:1373-1381.
10. Neer R, Arnaud C, Zanchetta J, Prince R, Gaich G, Reginster J-Y, Hodsman A, Eriksen E, Ish-Shalom S, Genant H, Wang O, Mitlak B. 2001. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Eng J Med 344: 1434-1441.
11. D'Amour P, Huet P-M. 1984. Evidence of two forms of hepatic extraction of parathyroid hormone in dogs in vivo. Am J Physiol 246:E249-E255.
12. Lee YH, Leesman GD, Makhey V, Yu H, Hu P, Perry B, Sutyak JP, Wagner EJ, Falzone LM, Stern W, Sinko PJ. 2000. Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs. Eur J Pharm Biopharm 50:205-211.
13. Kwei GY, Gehret JR, Novak LB, Drag MD, Goodwin T. 1995. Chronic catheterization of the intestines and portal vein for absorption experimentation in beagle dogs. Lab Animal Sci 45:683-685.
14. Cheng H, Jusko W. 1987. Mean residence time concepts for pharmacokinetic systems with nonlinear drug elimination described by the Michaelis-Menten equation. Pham Res 5:156-164.
15. 2+ concentration influences the hepatic extraction of bioactive human PTH (1-34) in rats. Am J Physiol 256: E87-E92.
16. Martin K, Hruska K, Greenwalt A, Klahb S, Slatopolsky E. 1976. Selective uptake of intact parathyroid hormone by the liver. J Clin Inv 58: 781-788.
17. D'Amour P, Huet P-M, Segre GV, Rosenblatt M. 1981. Characteristics of bovine parathyroid hormone extraction by dog liver in vivo. Am J Physiol 241:E208-E214.