Time domain 1H NMR as a new method to monitor softening of gelatin and HPMC capsule shells

Drug Development and Industrial Pharmacy

Volumn 32, Issue 10, 2006, Pages 1165-1173

  Kuentz, Martin ^a,b   Rothenhäusler, Benno ^a   Röthlisberger, Dieter ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

Author keywords

Gelatin; Hardness; HPMC; Liquid filled capsules; Texture Analysis; Time domain NMR

Indexed keywords

GELATIN; HYDROXYPROPYLMETHYLCELLULOSE; LICAPS; QUALICAPS; WATER; DRUG DERIVATIVE; HYDROGEN; METHYLCELLULOSE;

ANALYTIC METHOD; ARTICLE; CAPSULE FILLING; CORRELATION ANALYSIS; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG MANUFACTURE; FRACTIONATION; HARDNESS; HUMIDITY; HYDROPHILICITY; MATERIAL STATE; MATERIALS TESTING; MATHEMATICAL PARAMETERS; MECHANICAL PROBE; MOLECULAR MECHANICS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; RELAXATION TIME; RIGIDITY; WATER CONTENT; CHEMISTRY; DRUG FORMULATION; MECHANICS; METHODOLOGY; MICROCAPSULE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CAPSULES; CHEMISTRY, PHYSICAL; DRUG COMPOUNDING; GELATIN; HYDROGEN; MAGNETIC RESONANCE SPECTROSCOPY; MECHANICS; METHYLCELLULOSE; WATER;

EID: 33750850292     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040600683659     Document Type: Article

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