HSP70 binds to SHP2 and has effects on the SHP2-related EGFR/GAB1 signaling pathway

Biochemical and Biophysical Research Communications

Volumn 351, Issue 4, 2006, Pages 979-985

  Yoo, Jae Cheal ^a   Hayman, Michael J ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

EGF; EGFR; GAB1; HSP70; SHP2

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; HEAT SHOCK PROTEIN 70; PROTEIN TYROSINE PHOSPHATASE SHP 2; TRYPSIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; COMPLEX FORMATION; CONTROLLED STUDY; EXPERIMENTATION; GEL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VALIDATION PROCESS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; EPIDERMAL GROWTH FACTOR; HSP70 HEAT-SHOCK PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 33750843499     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.10.152     Document Type: Article

References (20)

1. Agazie Y.M., and Hayman M.J. Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. Mol. Cell. Biol. 23 (2003) 7875-7886
2. Klinghoffer R.A., and Kazlauskas A. Identification of a putative Syp substrate, the PDGF beta receptor. J. Biol. Chem. 270 (1995) 22208-22217
3. Ren Y., Meng S., Mei L., Zhao Z.J., Jove R., and Wu J. Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. J. Biol. Chem. 279 (2004) 8497-8505
4. Zhang S.Q., Yang W., Kontaridis M.I., Bivona T.G., Wen G., Araki T., Luo J., Thompson J.A., Schraven B.L., Philips M.R., and Neel B.G. Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol. Cell. 13 (2004) 341-355
5. Hanafusa H., Torii S., Yasunaga T., Matsumoto K., and Nishida E. Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. J. Biol. Chem. 279 (2004) 22992-22995
6. Wu C.J., O'Rourke D.M., Feng G.S., Johnson G.R., Wang Q., and Greene M.I. The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors. Oncogene 20 (2001) 6018-6025
7. Zhang S.Q., Tsiaras W.G., Araki T., Wen G., Minichiello L., Klein R., and Neel B.G. Receptor-specific regulation of phosphatidylinositol 3′-kinase activation by the protein tyrosine phosphatase Shp2. Mol. Cell. Biol. 22 (2002) 4062-4072
8. Morimoto R.I. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev. 12 (1998) 3788-3796
9. Bukau B., Deuerling E., Pfund C., and Craig E.A. Getting newly synthesized proteins into shape. Cell 101 (2000) 119-122
10. Frydman J. Folding of newly translated proteins in vivo: the role of molecular chaperones. Annu. Rev. Biochem. 70 (2001) 603-647
11. Hartl F.U., and Hayer-Hartl M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 295 (2002) 1852-1858
12. Agazie Y.M., and Hayman M.J. Development of an efficient "substrate-trapping" mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gab1, and three other proteins as target substrates. J. Biol. Chem. 278 (2003) 13952-13958
13. Park C.Y., and Hayman M.J. The tyrosines in the bidentate motif of the env-sea oncoprotein are essential for cell transformation and are binding sites for Grb2 and the tyrosine phosphatase SHP-2. J. Biol. Chem. 274 (1999) 7583-7590
14. Yoo J.C., Chang J.R., Kim S.H., Jang S.K., Wolgemuth D.J., Kim K., and Rhee K. NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi. Exp. Cell Res. 292 (2004) 393-402
15. Bardelli A., Longati P., Gramaglia D., Stella M.C., and Comoglio P.M. Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential. Oncogene 15 (1997) 3103-3111
16. Carlberg K., and Rohrschneider L.R. Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and phosphatidylinositol 3′-kinase in myeloid cells. J. Biol. Chem. 272 (1997) 15943-15950
17. Feng G.S., Shen R., Heng H.H., Tsui L.C., Kazlauskas A., and Pawson T. Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp. Oncogene 9 (1994) 1545-1550
18. Gale N.W., Kaplan S., Lowenstein E.J., Schlessinger J., and Bar-Sagi D. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature 363 (1993) 88-92
19. Mortaz E., Redegeld F.A., van der Heijden M.W., Wong H.R., Nijkamp F.P., and Engels F. Mast cell activation is differentially affected by heat shock. Exp. Hematol. 33 (2005) 944-952
20. Yart A., Laffargue M., Mayeux P., Chretien S., Peres C., Tonks N., Roche S., Payrastre B., Chap H., and Raynal P. A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor. J. Biol. Chem. 276 (2001) 8856-8864