Functional effects of EMD-57033 in isovolumically beating isolated rabbit hearts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 1 40-1, 1996, Pages

  Tobias, Anthony H ^a   Slinker, Bryan K ^a   Kirkpatrick, Robert D ^a   Campbell, Kenneth B ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

calcium sensitizer; contraction duration; ventricular passive properties; ventricular relaxation

Indexed keywords

5 [1 (3,4 DIMETHOXYBENZOYL) 1,2,3,4 TETRAHYDRO 6 QUINOLYL] 3,6 DIHYDRO 6 METHYL 2H 1,3,4 THIADIAZIN 2 ONE;

ANIMAL TISSUE; ARTICLE; DATA ANALYSIS; HEART CONTRACTION; HEART PERFUSION; ISOLATED HEART; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; RABBIT; STARLING LAW;

EID: 33750841077     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.1.h51     Document Type: Article

References (30)

1. Allen, D. G., B. R. Jewell, and J. W. Murray. The contribution of activation processes to the length-tension relation of cardiac muscle. Nature Lond. 248: 606-607, 1974.
2. Allen, D. G., and J. C. Kentish. Calcium concentrations in the myoplasm of skinned ferret ventricular muscle following changes in muscle length. J. Physiol. Lond. 407: 489-503, 1988.
3. Allen, D. G., and J. C. Kentish. The cellular basis of the length-tension relation in cardiac muscle. J. Mol. Cell. Cardiol. 17: 821-840, 1985.
4. Brenner, B. Changes in calcium sensitivity at the cross-bridge level. In: Modulation of Cardiac Calcium Sensitivity: A New Approach to Increasing the Strength of the Heart, edited by J. A. Lee and D. G. Allen. New York: Oxford University Press, 1993, p. 197-214.
5. Campbell, K. B., H. Taheri, R. D. Kirkpatrick, and B. K. Slinker. Single perturbed beat vs. steady-state beats for assessing systolic function in the isolated heart. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H1631-H1639, 1992.
6. Fabiato, A., and F. Fabiato. Dependence of the contractile activation of skinned cardiac cells on the sarcomere length. Nature Lond. 256: 54-56, 1975.
7. 2+ transient in rat myocardium. J. Mol. Cell. Cardiol. 23: 325-331, 1991.
8. Gambassi, G., M. C. Capogrossi, M. Klockow, and E. G. Lakatta. Enantiomeric dissection of the effects of the inotropic agent, EMD-53998, in single cardiac myocytes. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H728-H738, 1993.
9. Glantz, S. A., and B. K. Slinker. Primer of Applied Regression and Analysis of Variance. New York: McGraw-Hill, 1990.
10. Hajjar, R. J., and J. K. Gwathmey. Calcium-sensitizing inotropic agents in the treatment of heart failure: a critical view. Cardiovasc. Drugs Ther. 5: 961-966, 1991.
11. Herzig, J. W., J. C. Rüegg, and R. J. Solaro. Myocardial excitation-contraction coupling as influenced through modulation, of the calcium sensitivity of the contractile proteins. Heart Failure 6: 244-250, 1991.
12. Hibberd, M. G., and B. R. Jewell. Calcium- and length-dependent force production in rat ventricular muscle. J. Physiol. Lond. 329: 527-540, 1982.
13. 2+ binding to cardiac troponin C. Am. J. Physiol. 253 (Cell Physiol. 22): C90-C96, 1987.
14. Hofmann, P. A., and F. Fuchs. Evidence for a force-dependent component of calcium binding to cardiac troponin C. Am. J. Physiol. 253 (Cell Physiol. 22): C541-C546, 1987.
15. Jewell, B. R. A reexamination of the influence of muscle length on myocardial performance. Circ. Res. 40: 221-230, 1977.
16. Katz, A. M. Potential deleterious effects of inotropic agents in the therapy of chronic heart failure. Circulation 73, Suppl. III: III-184-III-190, 1986.
17. Kirkpatrick, R. D., K. B. Campbell, D. L. Bell, and H. Taheri. Method for studying arterial wave transmission effects on left ventricular function. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H1003-H1012, 1991.
18. Lee, J. A., and D. G. Allen. EMD 53998 sensitizes the contractile proteins to calcium in intact ferret ventricular muscle. Circ. Res. 69: 927-936, 1991.
19. Lee, J. A., and D. G. Allen. Altering the strength of the heart: basic mechanisms. In: Modulation of Cardiac Calcium Sensitivity: A New Approach to Increasing the Strength of the Heart. edited by J. A. Lee and D. G. Allen. New York: Oxford University Press, 1993, p. 1-36.
20. 2+-sensitizing agent. Pfluegers Arch. 421: 388-390, 1992.
21. Lues, I., N. Beier, R. Jonas, M. Klockow, and G. Haeusler. The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers. J. Cardiovasc. Pharmacol. 21: 883-892, 1993.
22. Sinmett, S. J., S. Lipscomb, C. C. Ashley, and I. P. Mulligan. The effect of EMD 57033, a novel cardiotonic agent, on the relaxation of skinned cardiac and skeletal muscle produced by photolysis of diazo-2, a caged calcium chelator. Pfluegers Arch. 425: 175-177, 1993.
23. Solaro, R. J., G. Gambassi, D. M. Warshaw, M. R. Keller, H. A. Spurgeon, N. Beier, and E. G. Lakatta. Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilments. Circ. Res. 73: 981-990, 1993.
24. Stefanson, I., D. V. Vassallo, and J. G. Mill. Left ventricular length dependent activation in the isovolumetric rat heart. Cardiovasc. Res. 24: 254-256, 1990.
25. Strauss, J. D., C. Bletz, and J. C. Rüegg. The calcium sensitizer EMD 53998 antagonizes phosphate-induced increases in energy cost of isometric tension in cardiac skinned fibres. Eur J. Pharmacol. 252: 219-224, 1994.
26. Strauss, J. D., C. Zeunger, and J. C. Rüegg. The positive inotrope calcium sensitizer EMD 53998 antagonizes phosphate action on cross-bridges in cardiac skinned fibers. Eur. J. Pharmacol. 227: 437-441, 1992.
27. Tobias, A. H., B. K. Slinker, R. D. Kirkpatrick, and K. B. Campbell. Mechanical determinants of left ventricular relaxation in isovolumically beating hearts. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H170-H177, 1995.
28. 2+ sensitization and phosphodiesterase III inhibitory effects in guinea pig myocardium. Circ. Res. 70: 1081-1090, 1992.
29. 2+-troponin C affinity in cardiac and slow skeletal muscle. Am. J. Physiol. 266 (Cell Physiol. 35): C1077-C1082, 1994.
30. 2+ in isolated ferret cardiac muscle. Circ. Res. 73: 61-70, 1993.