Helicobacter pylori infection and HFE hemochromatosis

Blood Cells, Molecules, and Diseases

Volumn 37, Issue 3, 2006, Pages 188-191

  Beutler, Ernest ^a   Gelbart, Terri ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Iron; Iron deficiency; Penetrance; Phenotype

Indexed keywords

HEMOGLOBIN; HFE PROTEIN; IRON; TRANSFERRIN;

ADULT; ARTICLE; CONTROL GROUP; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FERRITIN BLOOD LEVEL; GENE MUTATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HEMOCHROMATOSIS; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; PHENOTYPE; PHLEBOTOMY; PRIORITY JOURNAL;

FEMALE; FERRITINS; HELICOBACTER INFECTIONS; HEMOCHROMATOSIS; HEMOGLOBINS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HOMOZYGOTE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MUTATION, MISSENSE; TRANSFERRIN;

HELICOBACTER PYLORI;

EID: 33750829204     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2006.08.002     Document Type: Article

References (28)

1. Beutler E., Felitti V.J., Koziol J.A., Ho N.J., and Gelbart T. Penetrance of the 845G→A (C282Y) HFE hereditary haemochromatosis mutation in the USA. Lancet 359 (2002) 211-218
2. Åsberg A., Hveem K., Kruger O., and Bjerve K.S. Persons with screening-detected haemochromatosis: as healthy as the general population?. Scand. J. Gastroenterol. 37 (2002) 719-724
3. Adams P.C., Reboussin D.M., Barton J.C., McLaren C.E., Eckfeldt J.H., McLaren G.D., Dawkins F.W., Acton R.T., Harris E.L., Gordeuk V.R., Leiendecker-Foster C., Speechley M., Snively B.M., Holup J.L., Thomson E., Sholinsky P., Dixon D., Rivers C.A., Tucker D., Ware J.C., Anton-Culver H., Baca J.A., Bent T.C., Brunner L.C., and Dao M.M. Hemochromatosis and iron-overload screening in a racially diverse population. N. Engl. J. Med. 352 (2005) 1769-1778
4. Lee P.L., Gelbart T., West C., Halloran C., and Beutler E. Seeking candidate mutations that affect iron homeostasis. Blood Cells Mol. Diseases 29 (2002) 471-487
5. Merryweather-Clarke A.T., Cadet E., Bomford A., Capron D., Viprakasit V., Miller A., McHugh P.J., Chapman R.W., Pointon J.J., Wimhurst V.L.C., Livesey K.J., Tanphaichitr V., Rochette J., and Robson K.J.H. Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. Hum. Mol. Genet. 12 (2003) 2241-2247
6. Jacolot S., Le Gac G., Scotet V., Quere I., Mura C., and Ferec C. HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype. Blood 103 (2004) 2835-2840
7. Majore S., Binni F., Pennese A., De Santis A., Crisi A., and Grammatico P. HAMP gene mutation c.208T > C (p.C70R) identified in an Italian patient with severe hereditary hemochromatosis. Human Mutat. 23 (2004) 400
8. Lazarescu A., Snively B.M., and Adams P.C. Phenotype variation in C282Y homozygotes for the hemochromatosis gene. Clin. Gastroenterol. Hepatol. 3 (2005) 1043-1046
9. McCune C.A., Ravine D., Carter K., Jackson H.A., Hutton D., Hedderich J., Krawczak M., and Worwood M. Iron loading and morbidity among relatives of HFE C282Y homozygotes identified either by population genetic testing or presenting as patients. Gut 55 (2006) 554-562
10. Njajou O.T., Alizadeh B.Z., Aulchenko Y., Zillikens M.C., Pols H.A., Oostra B.A., Swinkels D.W., and Van Duijn C.M. Heritability of serum iron, ferritin and transferrin saturation in a genetically isolated population, the Erasmus Rucphen Family (ERF) study. Hum. Hered. 61 (2006) 222-228
11. Whitfield J.B., Cullen L.M., Jazwinska E.C., Powell L.W., Heath A.C., Zhu G., Duffy D.L., and Martin N.G. Effects of HFE C282Y and H63D polymorphisms and polygenic background on iron stores in a large community sample of twins. Am. J. Hum. Genet. 66 (2000) 1246-1258
12. Sheldon J.H. Haemochromatosis (1935), Oxford University Press, London
13. Beutler E. The HFE Cys282Tyr mutation as a necessary but not sufficient cause of hereditary hemochromatosis. Blood 101 (2003) 3347-3350
14. Beutler E., Waalen J., and Gelbart T. Chronic inflammation does not appear to modify the homozygous hereditary hemochromatosis phenotype. Blood Cells Mol. Diseases 35 (2005) 326-327
15. Cardenas V.M., Mulla Z.D., Ortiz M., and Graham D.Y. Iron deficiency and Helicobacter pylori infection in the United States. Am. J. Epidemiol. 163 (2006) 127-134
16. Dubois S., and Kearney D.J. Iron-deficiency anemia and Helicobacter pylori infection: a review of the evidence. Am. J. Gastroenterol. 100 (2005) 453-459
17. Choe Y.H., Lee J.E., and Kim S.K. Effect of Helicobacter pylori eradication on sideropenic refractory anaemia in adolescent girls with Helicobacter pylori infection. Acta Paediatr. 89 (2000) 154-157
18. Valiyaveettil A.N., Hamide A., Bobby Z., and Krishnan R. Effect of anti-Helicobacter pylori therapy on outcome of iron-deficiency anemia: a randomized, controlled study. Indian J. Gastroenterol. 24 (2005) 155-157
19. Waalen J., Felitti V.J., Gelbart T., Ho N.J., and Beutler E. Penetrance of hemochromatosis. Blood Cells Mol. Diseases 29 (2002) 418-432
20. Waalen J., Felitti V., Gelbart T., Ho N.J., and Beutler E. Prevalence of hemochromatosis-related symptoms in homozygotes for the C282Y mutation of the HFE gene. Mayo Clin. Proc. 77 (2002) 522-530
21. Beutler E., Felitti V., Ho N., and Gelbart T. Relationship of body iron stores to levels of serum ferritin, serum iron, unsaturated iron binding capacity and transferrin saturation in patients with iron storage disease. Acta Haematol. (Basel) 107 (2002) 145-149
22. Dufour C., Brisigotti M., Fabretti G., Luxardo P., Mori P.G., and Barabino A. Helicobacter pylori gastric infection and sideropenic refractory anemia. J. Pediatr. Gastroenterol. Nutr. 17 (1993) 225-227
23. Yip R., Limburg P.J., Ahlquist D.A., Carpenter H.A., O'Neill A., Kruse D., Stitham S., Gold B.D., Gunter E.W., Looker A.C., Parkinson A.J., Nobmann E.D., Petersen K.M., Ellefson M., and Schwartz S. Pervasive occult gastrointestinal bleeding in an Alaska native population with prevalent iron deficiency. Role of Helicobacter pylori gastritis. JAMA 277 (1997) 1135-1139
24. Kostaki M., Fessatou S., and Karpathios T. Refractory iron-deficiency anaemia due to silent Helicobacter pylori gastritis in children. Eur. J. Pediatr. 162 (2003) 177-179
25. Sugiyama T., Tsuchida M., Yokota K., Shimodan M., and Asaka M. Improvement of long-standing iron-deficiency anemia in adults after eradication of Helicobacter pylori infection. Intern. Med. 41 (2002) 491-494
26. Mahalanabis D., Islam M.A., Shaikh S., Chakrabarty M., Kurpad A.V., Mukherjee S., Sen B., Khaled M.A., and Varmund S.H. Haematological response to iron supplementation is reduced in children with asymptomatic Helicobacter pylori infection. Br. J. Nutr. 94 (2005) 969-975
27. Barabino A. Helicobacter pylori-related iron deficiency anemia: a review. Helicobacter 7 (2002) 71-75
28. Blaser M.J. Helicobacter pylori and other gastric Helicobacter species. In: Mandell G.L., Bennett J.E., and Dolin R. (Eds). Principles and Practice of Infectious Diseases (2006) 2557-2567