Topical treatment of experimental hydrofluoric acid skin burns by 2.5% calcium gluconate

Journal of Burn Care and Research

Volumn 27, Issue 6, 2006, Pages 889-894

  Roblin, Isabelle ^a,c   Urban, Martine ^a   Flicoteau, Domitille ^a   Martin, Chantel ^b   Pradeau, Dominique ^a  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^b Centre Universitaire des Saints Pères   (France)

^c UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCONATE CALCIUM; HYALURONIC ACID; PENTOBARBITAL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BURN; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; EXPOSURE; GEL; MALE; NONHUMAN; RAT; TREATMENT FAILURE;

ADMINISTRATION, TOPICAL; ANIMALS; AREA UNDER CURVE; BURNS, CHEMICAL; CALCIUM GLUCONATE; GELS; HYDROFLUORIC ACID; MALE; MODELS, ANIMAL; RATS; RATS, WISTAR; TIME FACTORS; TRAUMA SEVERITY INDICES; WOUND HEALING;

EID: 33750817018     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/01.BCR.0000245767.54278.09     Document Type: Article

References (19)

1. Bertolini JC. Hydrofluoric acid: a review of toxicity. J Emerg Med 1992;10:163-8.
2. Dibbell DG, Iverson RE, Jones W, et al. Hydrofluoric acid burns of the hand. J Bone Joint Surgery 1970;52:931-6.
3. Anderson WJ, Anderson JR. Hydrofluoric acid burns of the hand: Mechanism of injury and treatment. J Hand Surgery 1988;13A:52-7.
4. Tepperman PB. Fatality due to acute systemic fluoride poisoning following a hydrofluoric acid skin burn. J Occup Med 1980;22:691-2.
5. Greco RJ, Hartford CE, Haith LR JR, et al. Hydrofluoric acid-induced hypocalcemia. J Trauma 1988;28:1593-6.
6. Herbert K, Lawrence JC. Chemical burns. Burns 1989;15:381-4.
7. Carney SA, Hall M, Lawrence JC, et al. Rationale of the treatment of hydrofluoric acid burns. Br J Indust Med 1974;31:317-21.
8. Upfal M, Doyle C. Medical management of hydrofluoric acid exposure. J Occup Med 1990;32:726-31.
9. Bracken W, Cuppage F, Mac Laury R, et al. Comparative effectiveness of topical treatments for hydrofluoric acid burns. J Occup Med 1985;27:733-9.
10. Dunn BJ, MacKinnon MA, Knowlden NF, et al. Hydrofluoric acid dermal burns: An assessment of treatment efficacy using an experimental pig model. J Occup Med 1992;34:902-9.
11. Burkhart KK, Brent J, Kirk MA, et al. Comparison of topical magnesium and calcium treatment for dermal hydrofluoric acid burns. Ann Emerg Med 1994;24:9-13.
12. Browne TD. The treatment of hydrofluoric acid burns. J Soc Occup Med 1974;24:80-9.
13. Kirkpatrick JJR, Burd DAR. An algorithmic approach to the treatment of hydrofluoric acid burns. Burns 1995;21:495-9.
14. Yasuda H, Honda S, Yamamoto O, et al. Therapeutic effect of topical gluconate for hydrofluoric acid burn. Time limit for the start of treatment. J UOEH 1999;21:209-16.
15. Hojer J, Personne M, Hulten P, et al. Topical treatments for hydrofluoric acid burns: a blind controlled experimental study. J Toxicol Clin Toxicol 2002;40:861-6.
16. Seyb ST, Noordhoek L, Botens S, et al. A study to determine the efficacy of treatments for hydrofluoric acid burns. J Burn Care Rehab 1995;16:253-7.
17. El Saadi M, Hall A, Hall P, et al. Hydrofluoric acid dermal exposure. Vet Hum Toxicol 1989;31:243-7.
18. Hulten P, Hojer J, Ludwigs U, et al. Hexafluorine vs. standard decontamination to reduce systemic toxicity after dermal exposure to hydrofluoric acid. J Toxicol Clin Toxicol 2004;42:355-61.
19. Rötheli-Simmen B, Martinelli E, Mühlebach S. Formulation of a stable calcium gluconate gel for topical treatment of hydrofluoric acid burns. EHP 1996;2:176-80.