Acute thiamine deficiency in diabetic ketoacidosis: Diagnosis and management

Pediatric Critical Care Medicine

Volumn 7, Issue 6, 2006, Pages 595-599

  Clark, Jeff A ^a   Burny, Ilyas ^a   Sarnaik, Ashok P ^a   Audhya, Tapan K ^b  

^a CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

^b Vitamin Diagnostics   (United States)

Author keywords

Case report; Child; Diabetic ketoacidosis; Encephalopathy; Thiamine deficiency

Indexed keywords

GLUCOSE; INSULIN; THIAMINE;

ADOLESCENT; BRAIN DISEASE; BRAIN EDEMA; CASE REPORT; CHEMICAL ANALYSIS; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; DEHYDRATION; DIABETIC KETOACIDOSIS; DISEASE COURSE; DISEASE SEVERITY; DRUG RESPONSE; FEMALE; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; INTENSIVE CARE UNIT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; STRESS; TERTIARY HEALTH CARE; THIAMINE DEFICIENCY;

EID: 33750802394     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PCC.0000244463.59230.DA     Document Type: Article

References (37)

1. Witkowski AA, Heidemann SM, Abella E: Thiamine-responsive lactic acidosis, encephalopathy, and shock. J Pharm Technol 1998; 14:240-242
2. Haas RH: Thiamin and the brain. Annu Rev Nutr 1988; 8:483-515
3. Tanphaichitr V: Thiamine. In: Modern Nutrition in Health and Disease. Shils ME, Olson JA, Shike M, et al (Eds). Baltimore, Williams & Wilkins, 1998, pp 381-389
4. Tallaksen CM, Bohmer T, Karlsen J, et al: Determination of thiamin and its phosphate esters in human blood, plasma, and urine. Methods Enzymol 1997; 279:67-74
5. Baker H, Frank O, Fennelly JJ, et al: A method for assaying thiamine status in man and animals. Am J Clin Nutr 1964; 14:197-201
6. Smeets EH, Muller H, de Wael J: A NADH-dependent transketolase assay in erythrocyte hemolysates. Clin Chim Acta 1971; 33:379-386
7. Finglas PM: Thiamin. Int J Vitam Nutr Res 1993; 63:270-274
8. Hung SC, Hung SH, Tarnq DC, et al: Thiamine deficiency and unexplained encephalopathy in hemodialysis and peritoneal dialysis patients. Am J Kidney Dis 2001; 38:941-947
9. McDonnell CM, Pedreira CC, Vadamalayan B, et al: Diabetic ketoacidosis, hyperosmolarity and hypernatremia: Are high-carbohydrate drinks worsening initial presentation? Pediatr Diabetes 2005; 6:90-94
10. Bhagat CI, Garcia-Webb P, Beilby JP, et al: Unexplained osmolal gap in diabetic ketoacidosis (not due to acetone). Clin Chem 1990; 36:403-404
11. Saito N, Kimura M, Kuchiba A, et al: Blood thiamine levels in outpatients with diabetes mellitus. J Nutr Sci Vitaminol 1987; 33:421-430
12. Babaei-Jadidi R, Karachalias N, Kupich C, et al: High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic rats. Diabetologia 2004; 47:2235-2246
13. Karachalias N, Babaei-Jadidid R, Kupich C, et al: High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats. Ann NY Acad Sci 2005; 1043:777-783
14. Hobara R, Kato H, Sakamoto K: Effect of thiamine and thiamine levels on experimental alloxan induced diabetes mellitus. Jpn J Pharmacol 1983; 33:27-31
15. Neufeld EJ, Mandel H, Raz T, et al: Localization of the gene for thiamine-responsive megaloblastic anemia syndrome, on the long arm of chromosome 1, by homozygosity mapping. Am J Hum Genet 1997; 61:1335-1341
16. Neufeld EJ, Fleming JC, Tartaqlini E, et al: Thiamine-responsive megaloblastic anemia syndrome: A disorder of high-affinity thiamine transport. Blood Cells Mol Dis 2001; 27:135-138
17. Velez RJ, Myers B, Guber MS: Severe acute metabolic acidosis (acute beriberi): An avoidable complication of total parenteral nutrition. JPEN J Parenter Enteral Nutr 1985; 9:216-219
18. Kitamura K, Takahashi T, Tanaka H, et al: Two cases of thiamine deficiency-induced lactic acidosis during total parenteral nutrition. Tohoku J Exp Med 1993; 171:129-133
19. Ali BH, Al-Qarawi AA: Thiamin status in furosemide-treated rats. Pharmacol Res 2000; 42:21-24
20. Lubetsky A, Winaver J, Seliqmann H, et al: Urinary thiamine excretion in the rat: Effects of furosemide, other diuretics, and volume load. J Lab Clin Med 1999; 134:232-237
21. Rindi G, Laforenza U: Thiamine intestinal transport and related issues: Recent aspects. Proc Soc Exp Biol Med 2000; 224:246-255
22. Watson AJ, Walker JF, Tomkin GH, et al: Acute Wernickes encephalopathy precipitated by glucose loading. Ir J Med Sci 1981; 150:301-303
23. Zimitat C, Nixon PF: Glucose loading precipitates acute encephalopathy in thiamindeficient rats. Metab Brain Dis 1999; 14:1-20
24. Matz R: Hyperglycemic hyperosmolar syndrome. In: Ellenberg and Rifkin's Diabetes Mellitus. Porte D, Baron A (Eds). New York, McGraw-Hill, 2003, pp 587-599
25. Heroux M, Butterworth RF: Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental Wernicke's encephalopathy. Neurochem Res 1995; 20:87-93
26. Navarro D, Zwingmann C, Hazell AS, et al: Brain lactate synthesis in thiamine deficiency: A re-evaluation using 1H-13C nuclear magnetic resonance spectroscopy. J Neurosci Res 2005; 79:33-41
27. Munujos P, Coll-Canti J, Beleta J, et al: Brain pyruvate oxidation in experimental thiamin-deficiency encephalopathy. Clin Chim Acta 1996; 255:13-25
28. Zelaya FO, Rose SE, Nixon PF, et al: MRI demonstration of impairment of the blood-CSF barrier by glucose administration to the thiamin-deficient rat brain. Magn Reson Imaging 1995; 13:555-561
29. Kruse M, Navarro D, Desjardins P, et al: Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: Relationship to selective vulnerability. Neurochem Int 2004; 45:49-56
30. Hazell AS, Rao KV, Danbolt NC, et al: Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy. J Neurochem 2001; 78:560-568
31. Hazell AS, Pannunzio P, Rama Rao KV, et al: Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes. Glia 2003; 43:175-184
32. Butterworth RF, Heroux M: Effect of pyrithiamine treatment and subsequent thiamine rehabilitation on regional cerebral amino acids and thiamine-dependent enzymes. J Neurochem 1989; 52:1079-1084
33. Lonsdale D, Faulkner WR, Price W, et al: Pyruvic acidemia with hyperalaninemia: Vitamin B1 dependency. J Pediatr 1969; 74:827-828
34. Jungas RL: Hormonal regulation of pyruvate dehydrogenase. Metabolism, 1971; 20:43-53
35. Mukherjee C, Jungas RL: Activation of pyruvate dehydrogenase in adipose tissue by insulin. Evidence for an effect of insulin on pyruvate dehydrogenase phosphate phosphatase. Biochem J 1975; 148:229-235
36. Cooney GJ, Denyer GS, Jenkins AB, et al: In vivo insulin sensitivity of the pyruvate dehydrogenase complex in tissues of the rat. Am J Physiol Endocrinol Metab 1993; 265:E102-E107
37. Mandarino LJ, Wright KS, Verity LS, et al: Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism. J Clin Invest 1987; 80:655-663