Dual-color imaging of nascent angiogenesis and its inhibition in liver metastases of pancreatic cancer

Anticancer Research

Volumn 26, Issue 5 A, 2006, Pages 3237-3242

  Amoh, Yasuyuki ^a,b,c   Nagakura, Chisa ^a   Maitra, Anirban ^d   Moossa, A R ^b   Katsuoka, Kensei ^c   Hoffman, Robert M ^a,b   Bouvet, Michael ^b,e  

^a ANTICANCER INC   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d JOHNS HOPKINS HOSPITAL   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Angiogenesis; Green fluorescent protein (GFP); In vivo imaging; Metastasis; Mouse model; Nestin driven GFP transgenic mouse; Pancreatic cancer; Red fluorescence protein (RFP)

Indexed keywords

CD31 ANTIGEN; GEMCITABINE; GREEN FLUORESCENT PROTEIN; NESTIN DERIVED GREEN FLUORESCENT PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CELL PROLIFERATION; CONTROLLED STUDY; DENSITY; DRUG INHIBITION; ENDOTHELIUM CELL; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IMAGING SYSTEM; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; SPLEEN;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; DEOXYCYTIDINE; GREEN FLUORESCENT PROTEINS; HUMANS; INTERMEDIATE FILAMENT PROTEINS; LIVER NEOPLASMS; LUMINESCENT PROTEINS; MICE; MICE, INBRED C57BL; MICE, NUDE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; NEOVASCULARIZATION, PATHOLOGIC; NERVE TISSUE PROTEINS; PANCREATIC NEOPLASMS; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 33750742231     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Amoh Y, Yang M, Li L, Reynoso J, Bouvet M, Moossa AR, Katsuoka K and Hoffman RM: Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis. Cancer Res 65: 5352-5357, 2005.
2. Amoh Y, Li L, Yang M, Jiang P, Moossa AR, Katsuoka K and Hoffman RM: Hair follicle-derived blood vessels vascularize tumors in skin and are inhibited by Doxorubicin. Cancer Res 65: 2337-2343, 2005.
3. Amoh Y, Li L, Tsuji K, Moossa AR, Katsuoka K, Hoffman RM and Bouvet M: Dual-color imaging of nascent blood vessels vascularizing pancreatic cancer in an orthotopic model demonstrates antiangiogenesis efficacy of gemcitabine. J Surg Res 132: 164-169, 2006.
4. Mignone JL, Kukekov V, Chiang AS, Steindler D and Enikolopov G: Neural stem and progenitor cells in nestin-GFP transgenic mice. J Comp Neurol 469: 311-324, 2004.
5. Yamauchi K, Yang M, Jiang P, Xu M, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M and Hoffman RM: Development of real-time subcellular dynamic multicolor imaging of cancer cell trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res 66: 4208-4214, 2006.
6. Katz MH, Takimoto S, Spivack D, Moossa AR, Hoffman RM and Bouvet M: A novel red fluorescent protein orthotopic pancreatic cancer model for the preclinical evaluation of chemotherapeutics. J Surg Res 113: 151-160, 2003.
7. Solorzano CC, Baker CH, Bruns CJ, Killion JJ, Ellis LM, Wood J and Fidler IJ: Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Cancer Biother Radiopharm 16: 359-370, 2001.
8. Lee NC, Bouvet M, Nardin S, Jiang P, Baranov E, Rashidi B, Yang M, Wang X, Moossa AR and Hoffman RM: Antimetastatic efficacy of adjuvant gemcitabine in a pancreatic cancer orthotopic model. Clin Exp Metastasis 18: 379-384, 2000.
9. Garcea G, Lloyd TD, Gescher A, Dennison AR, Steward WP and Berry DP: Angiogenesis of gastrointestinal tumours and their metastases-a target for intervention? Eur J Cancer 40: 1302-1313, 2004.
10. Ko AH and Tempero MA: Treatment of Metastatic Pancreatic Cancer. J Natl Compr Cane Netw 3: 627-636, 2005.
11. Hou JM, Liu JY, Yang L, Zhao X, Tian L, Ding ZY, Wen YJ, Niu T, Xiao F, Lou YY, Tan GH, Deng HX, Li J, Yang JL, Mao YQ, Kan B, Wu Y, Li Q and Wei YQ: Combination of low-dose gemcitabine and recombinant quail vascular endothelial growth factor receptor-2 as a vaccine induces synergistic antitumor activities. Oncology 69: 81-87, 2005.
12. Yap R, Veliceasa D, Emmenegger U, Kerbel RS, McKay LM, Henkin J and Volpert OV: Metronomic low-dose chemotherapy boosts CD95-dependent antiangiogenic effect of the thrombospondin peptide ABT-510: a complementation antiangiogenic strategy. Clin Cancer Res 11: 6678-6685, 2005.
13. Bellone G, Novarino A, Chiappino I, Gramigni C, Carbone A, Addeo A, Tonel E, Bertetto O and Emanuelli G: Circulating vascular endothelial growth factor and interferon-gamma-inducible protein-10 levels in pancreatic cancer during chemotherapy. Anticancer Res 25: 3287-3291, 2005.
14. Jia L, Zhang MH, Yuan SZ and Huang WG: Antiangiogenic therapy for human pancreatic carcinoma xenografts in nude mice. World J Gastroenterol 11: 447-450, 2005.
15. Masaki T, Ohkawa S, Amano A, Ueno M, Miyakawa K and Tarao K: Noninvasive assessment of tumor vascularity by contrast-enhanced ultrasonography and the prognosis of patients with nonresectable pancreatic carcinoma. Cancer 103: 1026-1035, 2005.
16. Fu X, Guadagni F and Hoffman RM: A metastatic nude mouse model of human pancreatic cancer constructed orthotopically from histologically intact patient specimens. Proc Nat Acad Sci USA 89: 5445-5449, 1992.
17. Hoffman RM: The multiple uses of fluorescent proteins to visualize cancer in vivo. Nature Reviews Cancer 5: 796-806, 2005.