Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDA, in chronic myeloid leukemia (K562) cells

Molecular and Cellular Biochemistry

Volumn 292, Issue 1-2, 2006, Pages 99-105

  Wu, Zchong Zcho ^a   Chien, Ching Ming ^a   Yang, Sheng Huei ^a   Lin, Yi Hsiung ^a   Hu, Xiu Wei ^a   Lu, Yu Jhang ^a   Wu, Ming Jung ^a   Lin, Shinne Ren ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; G2 M arrest; K562 cells; THDA

Indexed keywords

2 [6 (2 THIEANISYL) 3 HEXEN 1,5 DIYNYL]ANILINE DERIVATIVE; ALKENYLDIALKYNE DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE 3; CYCLIN A; CYCLIN B1; CYCLIN D3; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P21; PROTEIN P27; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PROTEIN DEGRADATION; STEADY STATE;

ANILINE COMPOUNDS; APOPTOSIS; CASPASE 3; CELL SURVIVAL; ENEDIYNES; ENZYME ACTIVATION; G2 PHASE; HUMANS; IMMUNOBLOTTING; K562 CELLS; LEUKEMIA, MYELOID, CHRONIC; LYMPHOCYTES; MITOSIS;

EID: 33750733622     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-9222-7     Document Type: Article

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