Antiplatelet Effects of a Kampo Medicine, Orengedokuto

Journal of Stroke and Cerebrovascular Diseases

Volumn 15, Issue 6, 2006, Pages 277-282

  Kimura, Yoko ^a,b   Shimizu, Mie ^b   Kohara, Saori ^b   Yoshii, Fumihito ^b   Sato, Hiroshi ^a   Shinohara, Yukito ^b,c  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOKAI UNIVERSITY TOKYO HOSPITAL   (Japan)

Author keywords

antiplatelet therapy; cerebral infarction; Kampo medicine; orengedokuto; platelet activation; platelet aggregation

Indexed keywords

ADENOSINE DIPHOSPHATE; KAMPO; ORENGEDOKUTO; PADGEM PROTEIN; SARPOGRELATE; TICLOPIDINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BRAIN INFARCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL DENSITY; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

EID: 33750730265     PISSN: 10523057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2006.09.002     Document Type: Article

References (24)

1. Fuster V., Badimon L., Badimon J.J., et al. Pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med 326 (1992) 310-318
2. Nurden A.T., Macchi L., Bihour C., et al. Markers of platelet activation in coronary heart disease patients. Eur J Clin Invest 24 (1994) 42-45
3. Zeller J.A., Tschoepe D., and Kessler C. Circulating platelets show increased activation in patients with acute cerebral ischemia. Thromb Haemost 81 (1999) 373-377
4. Yamazaki M., Uchiyama S., and Iwata M. Measurement of platelet fibrinogen binding and P-selectin expression by flow cytometry in patients with cerebral infarction. Thromb Res 104 (2001) 197-205
5. Watanabe K., Miyakita Y., Inomata T., et al. Effect of Oren-gedoku-to on platelet aggregation. Acta Medica Biologica 39 (1991) 153-159
6. Mori M., Kitajou E., and Takano K. Determination of platelet aggregation for Orengedoku-to [in Japanese]. Igaku-to-Yakugaku 24 (1990) 397-401
7. Kawashima K., and Kogure K. Effect of oren-gedoku-to on cerebral vascular flow [in Japanese]. Gendai Iryo Gaku 5 (1989) 250-253
8. Sekine I., Shichijo K., Nishimori I., et al. Effects of oren-gedoku-to and tyoto-san on hypertensive lesions of stroke-prone spontaneously hypertensive rats (SHRSP). J Med Pharm Soc WAKAN-YAKU 3 (1986) 71-76
9. Ozaki Y., Satoh K., Yatomi Y., et al. Detection of platelet aggregates with a particle counting method using light scattering. Anal Biochem 218 (1994) 218-294
10. Shimizu M., Ando Y., Takei M., et al. Whole blood flow cytometry for detection of activated platelets I: Platelet identification, blood collection and storage. Rinsho Byori 49 (2001) 402-407
11. Shimizu M., Yamamoto M., Ando Y., et al. Detection of activated platelets in patients with cerebral infarction at the acute and chronic stages [in Japanese]. Jpn J Stroke 24 (2002) 234-239
12. Shimizu M., Kamio K., Haida M., et al. Platelet activation in patients with obstructive sleep apnea syndrome and effects of nasal-continuous positive airway pressure. Tokai J Exp Clin Med 27 (2002) 107-112
13. Michelson A.D. Flow cytometry: A clinical test of platelet function. Blood 87 (1996) 4925-4936
14. Shattil S.J., Cunningham M., and Hoxie J.A. Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood 70 (1987) 307-315
15. Wu K.K., and Hoak J.C. Increased platelet aggregates in patients with transient ischemic attacks. Stroke 6 (1975) 521-524
16. Uchiyama S., Takeuchi M., Osawa M., et al. Platelet function test in thrombotic cerebrovascular disorders. Stroke 14 (1983) 511-517
17. Hirabayashi H., Shimizu M., Kohara S., et al. Activated platelets in transient global amnesia and TIA. Neurology 63 (2004) 736-738
18. Shimizu M., Kohara S., Yamamoto M., et al. Significant relationship between platelet activation and intra-media thickness of carotid artery in patients with ischemic cerebrovascular disease. Thromb Res 117 (2006) 647-652
19. Kimoto H. Application of Kampo medicine to acute cerebral infarction: Summary of 14 cases and comparison of their clinical prognosis with the result of Japan standard stroke registry study (JSSRS). J Trad Med 20 (2003) 68-73
20. Ushikubo Y., Sakurai T., Yokouchi T., et al. The effects of "Oren-gedoku-to" and quantitative evaluation of cerebral blood flow for cerebrovascular diseases. J N Remedies Clin 47 (1998) 176-183
21. Takeda S., Isono T., Imai K., et al. Pharmacokinetic study of several ingredients after oral dose of TJ-23 (Toki-Shakuyaku-San) in rats. Jpn Pharmacol Ther 22 (1994) 249-254
22. Kubo M., Matsuda H., Tani T., et al. Studies on Scutellariae radix, XII: Anti-thrombic actions of various flavonoids from Scutellariae radix. Chem Pharm Bull (Tokyo) 33 (1985) 2411-2415
23. Huang C.G., Chu Z.L., Wei S.J., et al. Effects of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. Thromb Res 15 (2002) 223-227
24. Suzuki Y., Kondo K., Ikeda Y., et al. Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Med 67 (2001) 807-810