NOS activity in brain and endothelium: Relation to hypercapnic rise of cerebral blood flow in rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 5 40-5, 1996, Pages

  Fabricius, Martin ^a   Rubin, Inger ^b   Bundgaard, Magnus ^b   Lauritzen, Martin ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NONE

Author keywords

7 nitroindazole; acetylcholine; cerebral circulation; laser Doppler flowmetry; parallel fibers

Indexed keywords

7 NITROINDAZOLE; ACETYLCHOLINE; CARBON DIOXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; BRAIN BLOOD FLOW; BRAIN CIRCULATION; CONTROLLED STUDY; ENZYME ACTIVITY; HYPERCAPNIA; LASER DOPPLER FLOWMETRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

EID: 33750722862     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.5.h2035     Document Type: Article

References (35)

1. Akgoren, N., M. Fabricius, and M. Lauritzen. Importance of nitric oxide for local increases of blood flow in rat cerebellar cortex during electrical stimulation. Proc. Natl. Acad. Sci. USA 91: 5903-5907, 1994.
2. Babbedge, R. C., P. A. Blandward, S. L. Hart, and P. K. Moore. Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles. Br. J. Pharmacol. 110: 225-228, 1993.
3. Blandward, P. A., and P. K. Moore. 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci. 57: PL131-PL135, 1995.
4. Dinerman, J. L., T. M. Dawson, M. J. Schell, A. Snowman, and S. H. Snyder. Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity. Proc. Natl. Acad. Sci. USA 91: 4214-4218, 1994.
5. Dirnagl, U., B. Kaplan, M. Jacewicz, and W. Pulsinelli. Continuous measurement of cerebral cortical blood flow by laser-Doppler flowmetry in a rat stroke model. J. Cereb. Blood Flow Metab. 9: 589-596, 1989.
6. Fabricius, M., and M. Lauritzen. Examination of the role of nitric oxide for the hypercapnic rise of cerebral blood flow in rats. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H1457-H1464, 1994.
7. 14C]-iodoantipyrine method suggests discordance during cerebral blood flow increases. J. Cereb. Blood Flow Metab. 16: 156-161, 1995.
8. Faraci, F. M. Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H1038-H1042, 1991.
9. Forstermann, U., L. D. Gorsky, J. S. Pollock, H. H. Schmidt, M. Heller, and F. Murad. Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain. Biochem. Biophys. Res. Commun. 168: 727-732, 1990.
10. Griffith, O. W., and D. J. Stuehr. Nitric oxide synthases: properties and catalytic mechanism. Annu. Rev. Physiol. 57: 707-736, 1995.
11. Groves, W. E., F. C. Davis, Jr., and B. H. Sells. Spectrophotometric determination of microgram quantities of protein without nucleic acid interference. Anal. Biochem. 22: 195-210, 1968.
12. Hamada, J., J. H. Greenberg, S. Croul, T. M. Dawson, and M. Reivich. Effects of central inhibition of nitric oxide synthase on focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 15: 779-786, 1995.
13. Hecker, M., A. Mulsch, E. Bassenge, U. Forstermann, and R. Busse. Subcellular localization and characterization of nitric oxide synthase(s) in endothelial cells: physiological implications. Biochem. J. 299: 247-252, 1994.
14. Huang, P. L., T. M. Dawson, D. S. Bredt, S. H. Snyder, and M. C. Fishman. Targeted disruption of the neuronal nitric oxide synthase gene. Cell 75: 1273-1286, 1993.
15. Iadecola, C., D. A. Pelligrino, M. A. Moskowitz, and N. A. Lassen. Nitric oxide synthase inhibition and cerebrovascular regulation. J. Cereb. Blood Flow Metab. 14: 175-192, 1994.
16. Iadecola, C., F. Zhang, and X. Xu. Role of nitric oxide synthase-containing vascular nerves in cerebrovasodilation elicited from cerebellum. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R738-R746, 1993.
17. Iadecola, C., F. Zhang, and X. Xu. SIN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R228-R235, 1994.
18. Irikura, K., P. L. Huang, J. Y. Ma, W. S. Lee, T. Dalkara, M. C. Fishman, T. M. Dawson, S. H. Snyder, and M. A. Moskowitz. Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. Proc. Natl. Acad. Sci. USA 92: 6823-6827, 1995.
19. 2 inhalation in Sprague-Dawley rats. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H837-H843, 1994.
20. Kohling, R., A. Lehmenkuhler, C. Nicholson, and E. J. Speckmann. Superfusion of verapamil on the cerebral cortex does not suppress epileptic discharges due to restricted diffusion (rats, in vivo). Brain Res. 626: 149-155, 1993.
21. Llinás, R. Electrophysiology of cerebellar networks. In: Handbook of Physiology. The Nervous System. Motor Control. Bethesda, MD: Am. Physiol. Soc., 1981, sect. 1, vol. II, pt. 2, chapt. 17, p. 831-877.
22. Medhurst, A. D., C. Greenlees, A. A. Parsons, and S. J. Smith. Nitric oxide synthase inhibitors 7- and 6-nitroindazole relax smooth muscle in vitro. Eur. J. Pharmacol. 256: R5-6, 1994.
23. 5-[imino(nitroamino)methyl]-L-ornithine) impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from L-arginine. Naunyn-Schmiedeberg's Arch. Pharmacol. 341: 143-147, 1990.
24. Pease, D. C., and R. L. Schultz. Electron microscopy of rat cranial meninges. Am. J. Anat. 102: 301-320, 1958.
25. Peterson, D. A., D. C. Peterson, S. Archer, and E. K. Weir. The nonspecificity of specific nitric oxide synthase inhibitors. Biochem. Biophys. Res. Commun. 187: 797-801, 1992.
26. Salter, M., C. Duffy, and R. Hazelwood. Determination of brain nitric oxide synthase inhibition in vivo: ex vivo assays of nitric oxide synthase can give incorrect results. Neuropharmacology 34: 327-334, 1995.
27. Skinhoj, E., and O. B. Paulson. Carbon dioxide and cerebral circulatory control. Evidence of a nonfocal site of action of carbon dioxide on cerebral circulation. Arch. Neurol. 20: 249-252, 1969.
28. Toda, N., Y. Hatano, and K. Mori. Mechanisms underlying response to hypercapnia and bicarbonate of isolated dog cerebral arteries. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H141-H146, 1989.
29. Traystman, R. J., L. E. Moore, M. A. Helfaer, S. Davis, K. Banasiak, M. Williams, and P. D. Hurn. Nitro-L-arginine analogues: dose- and time-related nitric oxide synthase inhibition in brain. Stroke 26: 864-868, 1995.
30. Wagner, D. D., J. B. Olmsted, and V. J. Marder. Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. J. Cell Biol. 95: 355-360, 1982.
31. Wang, Q., D. A. Pelligrino, V. L. Baughman, H. M. Koenig, and R. F. Albrecht. The role of neuronal nitric oxide synthase in regulation of cerebral blood flow in normocapnia and hypercapnia in rats. J. Cereb. Blood Flow Metab. 15: 774-778, 1995.
32. 2 in vivo. J. Cereb. Blood Flow Metab. 14: 944-951, 1994.
33. Wang, Q., M. A. Theard, D. A. Pelligrino, V. L. Baughman, W. E. Hoffman, R. F. Albrecht, M. Cwik, O. B. Paulson, and N. A. Lassen. Nitric oxide (NO) is an endogenous anticonvulsant but not a mediator of the increase in cerebral blood flow accompanying bicuculline-induced seizures in rats. Brain Res. 658: 192-198, 1994.
34. Wolff, D. J., A. Lubeskie, and S. Umansky. The inhibition of the constitutive bovine endothelial nitric oxide synthase by imidazole and indazole agents. Arch. Biochem. Biophys. 314: 360-366, 1994.
35. You, J. P., Q. Wang, W. Zhang, I. Jansenolesen, O. B. Paulson, N. A. Lassen, and L. Edvinsson. Hypercapnic vasodilatation in isolated rat basilar arteries is exerted via low pH and does not involve nitric oxide synthase stimulation or cyclic GMP production. Acta Physiol. Scand. 152: 391-397, 1994.